FXR 10mg Tablet | Obeticholic Acid | 10pcs | Discount Price | ePharma
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FXR 10mg Tablet 10pcs

Generic: Obeticholic Acid

Type: Tablet

Pack Size: 10 Pcs

Obeticholic Acid 10mg-

  • Treats primary biliary cholangitis in adults

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Discount Price: ৳ 528
MRP: ৳ 550 4% Off

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Description:

FXR 10mg Tablet is classified as a Farnesoid X-receptor agonist medication used to treat primary biliary cirrhosis, also known as primary biliary cholangitis. This autoimmune disease damages the bile ducts in the liver, leading to a buildup of bile and liver damage.

FXR 10mg Tablet contains 'Obeticholic acid,' which aids in improving liver function by reducing bile production and accumulation, enhancing bile removal from the liver, and decreasing inflammation, thus treating primary biliary cirrhosis.

Safety Advices


Alcohol
CONSULT YOUR DOCTOR

Interaction with alcohol is unknown.


Pregnancy
UNSAFE

FXR 10mg Tablet is not recommended for use in pregnant women. Consult your doctor before taking FXR 10mg Tablet.   


Breastfeeding
CONSULT YOUR DOCTOR

It is not known whether FXR 10mg Tablet passes through breast milk. Consult your doctor before taking FXR 10mg Tablet.


Driving
CAUTION

FXR 10mg Tablet has no or negligible influence on your ability to drive or use machines.


Kidney
CONSULT YOUR DOCTOR

Please consult your doctor if you have kidney impairment or any concerns regarding this.


Liver
CONSULT YOUR DOCTOR

FXR 10mg Tablet is not recommended for use in patients with complete blockage of the biliary tract (liver, gall bladder, and bile ducts). Consult your doctor before taking FXR 10mg Tablet.

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Uses:

Primary Biliary Cirrhosis

How does FXR 10mg Tablet work?

Obeticholic acid activates the Farnesoid X receptor (FXR), which regulates bile acid synthesis, transport, lipid metabolism, and glucose level regulation. By inhibiting bile acid synthesis and increasing bile acid secretion, obeticholic acid reduces the bile acid pool in the liver, preventing its toxic effects and improving liver function.

Side Effects of FXR 10mg Tablet

The most common side effects of Obeticholic Acid are pruritus, fatigue, and stomach pain and discomfort. Other common adverse effects include rashes, arthralgia (joint pain), oropharyngeal discomfort (pain in the middle of the throat), dizziness, constipation, altered thyroid function, and eczema (skin inflammation).

Quick Suggestions:

A dietary plan plays a crucial role in managing primary biliary cholangitis. Here are some dietary recommendations for individuals with this condition:

Include the following foods in your diet:

  • Bell peppers
  • Citrus fruits
  • Leafy vegetables
  • Tomatoes
  • Milk
  • Fish
  • Low-fat dairy products
  • Beans
  • Nuts
  • Lentils
  • Tofu
  • Tempeh

It's essential to maintain a healthy, well-balanced diet that emphasizes fruits and vegetables. These foods provide essential nutrients and antioxidants that can support liver health.

  • Avoid high-fat and trans-fat foods, as excessive fat intake can strain the liver.
  • Minimize the consumption of processed foods, which often contain additives and preservatives that may not be liver-friendly.
  • Eliminate or limit the intake of white bread, white pasta, and added sugars. These can lead to weight gain and inflammation.
Indication

Obeticholic Acid is used to treat primary biliary cholangitis (PBC) in individuals who have not responded well to UDCA, as well as cholestatic liver disease and non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH).

Pharmacology

Obeticholic Acid activates FXR, a nuclear receptor found in the liver and gut. FXR plays a crucial role in regulating bile acid, inflammatory, fibrotic, and metabolic pathways. By reducing de novo cholesterol production and increasing bile acid transport out of hepatocytes, FXR activation decreases intracellular hepatocyte bile acid levels. These actions reduce hepatic bile acid exposure by limiting the total amount of circulating bile acids while increasing choleresis.

Dosage & Administration of FXR 10mg Tablet

Starting Dosage: The recommended initial dose of Obeticholic Acid is 5 mg orally once daily for adult patients who have not achieved an adequate biochemical response to an appropriate dose of Ursodeoxycholic Acid (UDCA) for at least one year or who are intolerant to UDCA.

Dosage Titration: If an adequate reduction in alkaline phosphatase (ALP) and/or total bilirubin has not been achieved after three months of Obeticholic Acid 5 mg once daily, and the patient tolerates Obeticholic Acid, increase the dose to 10 mg once daily.

Maximum Dosage: The maximum recommended dose of Obeticholic Acid is 10 mg once daily.

Management of Patients with Intolerable Pruritus on Obeticholic Acid: For patients experiencing intolerable pruritus while taking Obeticholic Acid, consider one or more of the following:

  1. Add an antihistamine or bile acid-binding resin.
  2. Reduce the dose of Obeticholic Acid to:
    • 5 mg every other day for patients intolerant to 5 mg once daily
    • 5 mg once daily for patients intolerant to 10 mg once daily
  3. Temporarily interrupt Obeticholic Acid treatment for up to two weeks, followed by restarting at a reduced dose.
Interaction

Bile acid binding resins, such as cholestyramine, colestipol, or colesevelam, adsorb and inhibit bile acid absorption, which may reduce Obeticholic Acid absorption, systemic exposure, and efficacy. If taking a bile acid binding resin, administer Obeticholic Acid at least four hours before or after the bile acid binding resin, or at the earliest practicable interval.

Warfarin: Co-administration of Obeticholic Acid and warfarin resulted in a decrease in the International Normalized Ratio (INR). When combining Obeticholic Acid with warfarin, monitor the INR and adjust the warfarin dose as necessary to stay within the target range.

Narrow Therapeutic Index CYP1A2 Substrates: Obeticholic Acid may increase exposure to concomitant CYP1A2 substrates. Therapeutic monitoring is required for CYP1A2 substrates with a limited therapeutic index.

Contraindications

Obeticholic Acid should not be used by patients with known hypersensitivity to the drug or any of its components, as well as individuals with total biliary obstruction.

Pregnancy & Lactation

There is insufficient human data on the use of Obeticholic Acid during pregnancy to establish the risk associated with the drug. There is no information on the presence of Obeticholic Acid in human milk, its effects on breastfed infants, or its impact on milk production.

Precautions & Warnings

Specialized monitoring is necessary for patients with the following clinically significant reactions:

  • Severe pruritus
  • Reduction in low-density lipoprotein-cholesterol (HDL-C)
Storage Conditions

Store between 15°C and 30°C in a dry, light-protected place. Keep it out of reach of children.

Frequently Asked Questions (FAQ)

Do not discontinue FXR 10mg Tablet without consulting your doctor. To treat your condition effectually, continue taking OBETICHOLIC ACID for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking OBETICHOLIC ACID.

FXR 10mg Tablet helps improve liver functioning by reducing the production and build-up of bile in the liver and reduces inflammation.

Yes

FXR 10mg Tablet is not recommended for use in patients with complete blockage of the biliary tract (liver, gall bladder and bile ducts). Consult your doctor before taking OBETOHEP 10MG.
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Check our pricing section for FXR 10mg Tablet 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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