Primary biliary cholangitis (PBC), previously referred to as primary biliary cirrhosis, is a chronic liver condition characterized by the gradual destruction of the intrahepatic bile ducts in the liver.
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Interaction with alcohol is unknown.
Duoliv 5mg Tablet is not recommended for use in pregnant women. Consult your doctor before taking Duoliv 5mg Tablet.
It is not known whether Duoliv 5mg Tablet passes through breast milk. Consult your doctor before taking Duoliv 5mg Tablet.
Duoliv 5mg Tablet has no or negligible influence on your ability to drive or use machines.
Please consult your doctor if you have kidney impairment or any concerns regarding this.
Duoliv 5mg Tablet is not recommended for use in patients with complete blockage of the biliary tract (liver, gall bladder, and bile ducts). Consult your doctor before taking Duoliv 5mg Tablet
Obiholic Tablet works by attaching to certain proteins in the liver and gut that control the production of a substance called bile. This reduces the production of bile in the liver and prevents it from building up and damaging the liver tissue.
Obeticholic acid is a medication used either on its own or in combination with ursodiol (Actigall, Urso) to treat primary biliary cholangitis (PBC). PBC is a type of liver disease that results in the destruction of bile ducts in the liver, leading to the accumulation of bile within the liver and causing damage. Obeticholic acid belongs to a class of drugs known as farnesoid X receptor agonists. It operates by reducing the production of bile in the liver and enhancing the removal of bile from the liver, which helps in managing PBC. This medication is typically prescribed for individuals who cannot take ursodiol or those who did not respond successfully to treatment with ursodiol alone.
Obeticholic acid activates a nuclear receptor called FXR, which is found in the liver and gut. This activation of Obeticholic acid plays a crucial role in regulating various pathways, including those related to bile acids, inflammation, fibrosis, and metabolism. Obeticholic acid helps decrease the concentration of bile acids within liver cells by reducing the production of new cholesterol and increasing the transport of bile acids out of these cells. This strategy effectively limits the exposure of liver cells to bile acids, reducing the overall pool of circulating bile acids and promoting their removal from the liver.
The recommended starting dosage of Obeticholic Acid is 5 mg orally once daily for adult patients who have not achieved an adequate biochemical response to an appropriate dose of Ursodeoxycholic Acid (UDCA) for at least 1 year or are intolerant to UDCA.
If, after 3 months of taking Obeticholic Acid at a 5 mg once daily dose, the patient has not achieved an adequate reduction in alkaline phosphatase (ALP) and/or total bilirubin levels, and they are tolerating Obeticholic Acid, the dosage may be increased to 10 mg once daily.
The maximum recommended dosage of Obeticholic Acid is 10 mg once daily.
For patients who experience intolerable pruritus (itching) while taking Obeticholic Acid, the following options can be considered:
Obiholic Tablets may interact with other medicines, potentially affecting their effectiveness or the effectiveness of other medications taken concurrently. It is crucial to inform your doctor about all the medicines, supplements, or herbal products you are currently taking or plan to take to avoid potential interactions.
Notably, the concurrent use of Obiholic Tablet with bile acid binding resins (such as cholestyramine, colestipol, and colesevelam) may reduce the efficacy of Obiholic Tablet.
Moreover, if you are taking medications for conditions such as asthma or chronic obstructive pulmonary disorder (theophylline), muscle cramps (tizanidine), or blood clots (warfarin), particular care should be exercised, as interactions may occur. It's essential to consult your healthcare provider to ensure the safe and effective use of these medications together.
Patients with known hypersensitivity to the medicine or any of its components, as well as those with total biliary obstruction, should not use it.
The available data on the use of Obeticholic Acid during pregnancy is limited, and therefore, there is not enough information to determine whether there are specific risks associated with this drug during pregnancy. Additionally, there is no available information regarding the presence of Obeticholic Acid in human milk, its effects on breastfed infants, or its impact on milk production. If you are pregnant or breastfeeding and your doctor is considering prescribing Obeticholic Acid, it is essential to have a thorough discussion about the potential risks and benefits of using the medication in your specific situation.
Before taking Duoliv 5mg Tablet,
Store it at room temperature and away from excess heat and moisture
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