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Rovantin 200mg Tablet 1 Strip
Rovantin contains Cefpodoxime, a third-generation oral cephalosporin with strong resistance to beta-lactamases and effective action against both Gram-positive and Gram-negative bacteria. As a prodrug, it is metabolized into its active form, Cefpodoxime, which works against a broad range of bacteria.
- Excretion: About 29-33% of the drug is excreted unchanged via urine within 12 hours.
- Stability: Highly stable in the presence of β-lactamase enzymes, making it more effective against Gram-positive bacteria than other third-generation cephalosporins.
- Susceptible Organisms: Includes S. aureus, S. saprophyticus, S. pneumoniae, S. pyogenes, E. coli, K. pneumoniae, H. influenzae, M. catarrhalis, N. gonorrhoeae, P. mirabilis, and others.
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✅ Description:
Rovantin is prescribed for infections caused by susceptible microorganisms, including:
- Ear Infections (Acute Otitis Media): Caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis (including beta-lactamase-producing strains).
- Throat Infections (Pharyngitis/Tonsillitis): Due to Streptococcus pyogenes.
- Sinus Infections (Acute Maxillary Sinusitis): Caused by H. influenzae, S. pneumoniae, and M. catarrhalis (including beta-lactamase-producing strains).
- Community-Acquired Pneumonia: Due to S. pneumoniae and H. influenzae (including beta-lactamase-producing strains).
- Chronic Bronchitis Exacerbations: Caused by S. pneumoniae, H. influenzae (non-beta-lactamase-producing strains), and M. catarrhalis.
- Skin & Soft Tissue Infections: Caused by Staphylococcus aureus and Streptococcus pyogenes.
- Urinary Tract Infections (UTIs): Due to E. coli, K. pneumoniae, Proteus mirabilis, and Staphylococcus saprophyticus.
- Uncomplicated Gonorrhea & Rectal Gonococcal Infections in Women: Caused by Neisseria gonorrhoeae (including penicillinase-producing strains).
Note: This medication should only be used as per a registered physician’s advice.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
For Adults & Adolescents (13+ years):
- Pharyngitis/Tonsillitis: 100 mg every 12 hours for 5–10 days.
- Acute Sinusitis: 200 mg every 12 hours for 10 days.
- Community-acquired pneumonia: 200 mg every 12 hours for 14 days.
- Chronic Bronchitis Exacerbation: 200 mg every 12 hours for 10 days.
- Skin Infections: 400 mg every 12 hours for 7–14 days.
- Uncomplicated UTI: 100 mg every 12 hours for 7 days.
- Uncomplicated Gonorrhea & Rectal Gonococcal Infections: Single 200 mg dose.
For Children (2 months–12 years):
- Acute Otitis Media: 5 mg/kg every 12 hours for 5 days.
- Pharyngitis/Tonsillitis: 5 mg/kg every 12 hours for 5–10 days.
- Acute Sinusitis: 5 mg/kg every 12 hours for 10 days.
For Patients with Kidney Issues:
- Severe Renal Impairment (Creatinine Clearance <30 ml/min): Dosage interval should be extended to once every 24 hours.
For Patients with Liver Cirrhosis:
- No dosage adjustment is necessary as the pharmacokinetics remain similar to healthy individuals.
✔️ Drug Interactions
- Antacids & H₂ Blockers: Reduce absorption and peak plasma levels by 24–42%, lowering effectiveness.
- Probenecid: Increases Cefpodoxime concentration by reducing renal excretion (31% increase in AUC).
- Nephrotoxic Medications: When taken with other nephrotoxic drugs, kidney function should be closely monitored.
✔️ Rovantin is well-tolerated but may cause mild side effects, including:
- Common: Diarrhea, nausea, abdominal pain, headache, dizziness, and fungal infections (skin & vaginal).
- Less Common: Chest pain, muscle pain, indigestion, vertigo, and cough.
- Children: Higher likelihood of skin fungal rashes compared to adults.
✔️ Contraindications:
Patients allergic to Cefpodoxime or cephalosporin antibiotics should avoid using this medication.
✔️ Use in Pregnancy & Lactation
- Pregnancy: Animal studies show no harmful effects, but no well-controlled human studies exist. Use only if necessary.
- Breastfeeding: Since Cefpodoxime is excreted in breast milk, a decision should be made to either discontinue the drug or breastfeed.
✔️ Precautions & Warnings
- Kidney Disease: Dosage should be adjusted in patients with reduced kidney function.
- Diuretic Use: Caution is advised when used with potent diuretics, as they may enhance the risk of renal impairment.
- Long-Term Use: May cause overgrowth of non-susceptible organisms. Regular monitoring is recommended.
✔️ Storage Instructions
- Store in a cool, dry place away from direct light and heat.
- Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
