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Rovantin 200mg Tablet 1 Strip
Rovantin contains Cefpodoxime, a third-generation oral cephalosporin with strong resistance to beta-lactamases and effective action against both Gram-positive and Gram-negative bacteria. As a prodrug, it is metabolized into its active form, Cefpodoxime, which works against a broad range of bacteria.
- Excretion: About 29-33% of the drug is excreted unchanged via urine within 12 hours.
- Stability: Highly stable in the presence of β-lactamase enzymes, making it more effective against Gram-positive bacteria than other third-generation cephalosporins.
- Susceptible Organisms: Includes S. aureus, S. saprophyticus, S. pneumoniae, S. pyogenes, E. coli, K. pneumoniae, H. influenzae, M. catarrhalis, N. gonorrhoeae, P. mirabilis, and others.
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✅ Description:
Rovantin is prescribed for infections caused by susceptible microorganisms, including:
- Ear Infections (Acute Otitis Media): Caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis (including beta-lactamase-producing strains).
- Throat Infections (Pharyngitis/Tonsillitis): Due to Streptococcus pyogenes.
- Sinus Infections (Acute Maxillary Sinusitis): Caused by H. influenzae, S. pneumoniae, and M. catarrhalis (including beta-lactamase-producing strains).
- Community-Acquired Pneumonia: Due to S. pneumoniae and H. influenzae (including beta-lactamase-producing strains).
- Chronic Bronchitis Exacerbations: Caused by S. pneumoniae, H. influenzae (non-beta-lactamase-producing strains), and M. catarrhalis.
- Skin & Soft Tissue Infections: Caused by Staphylococcus aureus and Streptococcus pyogenes.
- Urinary Tract Infections (UTIs): Due to E. coli, K. pneumoniae, Proteus mirabilis, and Staphylococcus saprophyticus.
- Uncomplicated Gonorrhea & Rectal Gonococcal Infections in Women: Caused by Neisseria gonorrhoeae (including penicillinase-producing strains).
Note: This medication should only be used as per a registered physician’s advice.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
For Adults & Adolescents (13+ years):
- Pharyngitis/Tonsillitis: 100 mg every 12 hours for 5–10 days.
- Acute Sinusitis: 200 mg every 12 hours for 10 days.
- Community-acquired pneumonia: 200 mg every 12 hours for 14 days.
- Chronic Bronchitis Exacerbation: 200 mg every 12 hours for 10 days.
- Skin Infections: 400 mg every 12 hours for 7–14 days.
- Uncomplicated UTI: 100 mg every 12 hours for 7 days.
- Uncomplicated Gonorrhea & Rectal Gonococcal Infections: Single 200 mg dose.
For Children (2 months–12 years):
- Acute Otitis Media: 5 mg/kg every 12 hours for 5 days.
- Pharyngitis/Tonsillitis: 5 mg/kg every 12 hours for 5–10 days.
- Acute Sinusitis: 5 mg/kg every 12 hours for 10 days.
For Patients with Kidney Issues:
- Severe Renal Impairment (Creatinine Clearance <30 ml/min): Dosage interval should be extended to once every 24 hours.
For Patients with Liver Cirrhosis:
- No dosage adjustment is necessary as the pharmacokinetics remain similar to healthy individuals.
✔️ Drug Interactions
- Antacids & H₂ Blockers: Reduce absorption and peak plasma levels by 24–42%, lowering effectiveness.
- Probenecid: Increases Cefpodoxime concentration by reducing renal excretion (31% increase in AUC).
- Nephrotoxic Medications: When taken with other nephrotoxic drugs, kidney function should be closely monitored.
✔️ Rovantin is well-tolerated but may cause mild side effects, including:
- Common: Diarrhea, nausea, abdominal pain, headache, dizziness, and fungal infections (skin & vaginal).
- Less Common: Chest pain, muscle pain, indigestion, vertigo, and cough.
- Children: Higher likelihood of skin fungal rashes compared to adults.
✔️ Contraindications:
Patients allergic to Cefpodoxime or cephalosporin antibiotics should avoid using this medication.
✔️ Use in Pregnancy & Lactation
- Pregnancy: Animal studies show no harmful effects, but no well-controlled human studies exist. Use only if necessary.
- Breastfeeding: Since Cefpodoxime is excreted in breast milk, a decision should be made to either discontinue the drug or breastfeed.
✔️ Precautions & Warnings
- Kidney Disease: Dosage should be adjusted in patients with reduced kidney function.
- Diuretic Use: Caution is advised when used with potent diuretics, as they may enhance the risk of renal impairment.
- Long-Term Use: May cause overgrowth of non-susceptible organisms. Regular monitoring is recommended.
✔️ Storage Instructions
- Store in a cool, dry place away from direct light and heat.
- Keep out of children’s reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
