Taxetil Powder for Suspension 50 ml

Taxetil is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), urinary tract, ear, nasal sinus, throat, and skin. It kills bacteria, which helps to improve your symptoms and cure the infection. Taxetil should be taken with food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. It will not work for viral infections such as flu or the common cold. Using any antibiotic when you do not need it can make it less effective for future infections. The most common side effects of this medicine include rash, vomiting, nausea, and diarrhea. Taking this medicine along with some food may help to prevent indigestion and upset stomach. Consult your doctor if you find these side effects bother or worry you. Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. This medicine is generally regarded as safe to use in pregnancy and breastfeeding if prescribed by your doctor. It may blur your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Uses of Taxetil

• Bacterial infections

Side effects of Taxetil

Common

• Rash
• Nausea
• Diarrhea

How to use Taxetil

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Taxetil is to be taken with food.

How Taxetil works

Taxetil is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

What if you forget to take Taxetil?

If you miss a dose of Taxetil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

• Your doctor has prescribed Taxetil to cure your infection and improve your symptoms.
• Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
• Discontinue Taxetil and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
• Take it with food to avoid an upset stomach.
• Avoid consuming alcohol while taking Taxetil as it may cause increased side effects.

Brief Description

Indication

Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis

Administration

Should be taken with food. Take after meals. Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.

Adult Dose

Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis 200 mg PO q12hr for 10 days Acute Community-Acquired Pneumonia 200 mg PO q12hr for 14 days Pharyngitis/Tonsillitis 100 mg PO q12hr for 5-10 days Skin/Skin Structure Infections 400 mg PO q12hr for 7-14 days Uncomplicated gonorrhoea 200 mg as a single dose Uncomplicated Urinary Tract Infections 100 mg PO q12hr for 7-14 days Hepatic impairment Dosage adjustment not necessary

Child Dose

Child : PO 10 mg/kg/day, max 400 mg/day q12h 6 months - 2 years : 40 mg every 12 hours 3 - 8 years : 80 mg every 12 hours over 9 years : 100 mg every 12 hours

Renal Dose

Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session. CrCl (ml/min) Dosage Recommendation 10-39 Increase dosing intervals to 24 hrly. <10 Increase dosing intervals to 48 hrly.

Contraindication

Hypersensitivity.

Mode of Action

Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Precaution

History of allergy to penicillin; severe renal impairment; pregnancy and lactation. Lactation: Drug excreted in breast milk in low concentrations; not recommended

Side Effect

>10% Diarrhea in infants and toddlers (15.4%),Diaper rash (12.1%) 1-10% Diarrhea (7.4%),Nausea (3.8%),Vaginal infection (3.1%),Vomiting (1.1-2.1%),Abdominal pain (1.6%),Rash (1.4%),Headache (1.1%) Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.

Pregnancy Category Note

Pregnancy category: B Lactation: Drug excreted in breast milk in low concentrations; not recommended

Interaction

Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion. Potentially Fatal: Monitor renal function during admin. Additive nephrotoxic effects with furosemide.