Furoclav 500mg Tablet

Uses of Furoclav 500 Tablet

• Treatment of Bacterial infections

Side Effects of Furoclav 500 Tablet

• Diarrhea
• Nausea
• Vomiting
• Stomach pain
• Flatulence (gas)
• Indigestion
• Headache
• Itching and swelling in the vagina, painful urination
• Itching, redness

How does Furoclav 500 Tablet work?

Furoclav 500 Tablet is a combination of cefuroxime and clavulanic acid. Cefuroxime works by preventing the formation of bacterial cell walls, thereby stopping the infection to spread. Clavulanic Acid reduces resistance and enhances the activity of Cefuroxime against bacteria. It is a beta-lactamase inhibitor that blocks the action of certain enzymes of bacteria.

Quick Suggestions:

• Complete the course of Furoclav 500 Tablet given by your doctor. Do not miss any doses and take your medicine on time.
• It is a higher antibiotic and reserved for specific infections only, do not self-medicate with this medicine. Take proper medical advice before taking this medicine.
• If you develop an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while taking Furoclav 500 Tablet, stop taking it immediately and notify your doctor.
• Inform your doctor about all other medicines you take and your medical history if any.
• Diarrhea, nausea, vomiting, stomach pain, and indigestion can be seen as side effects of this medicine, inform your doctor if the side effects do not resolve over time.
• Furoclav 500 Tablet should be taken as prescribed by your doctor and for the duration, it has been prescribed.

Indication

Furoclav 500 Tablet is an antibiotic medication used to treat various bacterial infections such as throat infections, ear infections, sinus infections, sexually transmitted diseases (gonorrhea), Lyme disease, bloodstream infections, meningitis, respiratory tract infections, skin infections, urinary tract infections, and bone/joint infections. It contains two antibiotics, Cefuroxime (a cephalosporin antibiotic) and Clavulanic acid (a beta-lactamase inhibitor). Cefuroxime works by preventing the formation of the bacterial cell wall, leading to bacterial death. Clavulanic acid helps to enhance the effectiveness of cefuroxime against bacteria and reduces bacterial resistance. Together, Furoclav 500 Tablet effectively treats bacterial infections caused by both gram-positive and gram-negative bacteria, including strains that produce beta-lactamase.

Pharmacology

Cefuroxime is a potent second-generation cephalosporin antibiotic that has a bactericidal effect, meaning it kills a broad range of bacteria including both Gram-positive and Gram-negative strains. It is effective against many bacteria that produce beta-lactamase, an enzyme that can inactivate antibiotics. Cefuroxime acts by disrupting the transpeptidation process, which is involved in the synthesis of bacterial cell walls.

Clavulanic acid, derived from Streptomyces clavuligerus, is a natural beta-lactamase inhibitor. Its chemical structure resembles that of beta-lactam antibiotics, and it has the ability to bind irreversibly to beta-lactamase enzymes. By inhibiting these enzymes, clavulanic acid prevents them from degrading Cefuroxime. This protective action enhances the efficacy of Cefuroxime against bacterial infections, making it an effective treatment option.

Dosage & Administration of Furoclav 500 Tablet

For adolescents and adults (13 years and older), the recommended dosage of Cefuroxime-Clavulanic Acid for various infections is as follows:

• Pharyngitis/tonsillitis: Take 250 mg twice daily (b.i.d.) for 5-10 days.
• Acute bacterial maxillary sinusitis: Take 250 mg twice daily (b.i.d.) for 10 days.
• Acute bacterial exacerbation of chronic bronchitis: Take 250-500 mg twice daily (b.i.d.) for 10 days.
• Secondary bacterial infections of acute bronchitis: Take 250-500 mg twice daily (b.i.d.) for 5-10 days.
• Uncomplicated skin and skin structure infections: Take 250-500 mg twice daily (b.i.d.) for 10 days.
• Uncomplicated urinary tract infections: Take 250 mg twice daily (b.i.d.) for 7-10 days.
• Uncomplicated Gonorrhoea: Take a single dose of 1000 mg twice daily (b.i.d.).
• Community-acquired pneumonia: Take 250-500 mg twice daily (b.i.d.) for 5-10 days.
• MDR (Multi-Drug Resistant) Typhoid Fever: Take 500 mg twice daily (b.i.d.) for 10-14 days.
• Early Lyme disease: Take 500 mg twice daily (b.i.d.) for 20 days.

For pediatric patients (3 months to 12 years), the recommended dosage is as follows:

• Pharyngitis/Tonsillitis: Take 20 mg/kg/day twice daily (b.i.d.) for 5-10 days.
• Acute otitis media: Take 30 mg/kg/day twice daily (b.i.d.) for 10 days.
• Acute bacterial maxillary sinusitis: Take 30 mg/kg/day twice daily (b.i.d.) for 10 days.
• Impetigo: Take 30 mg/kg/day twice daily (b.i.d.) for 10 days.

Furoclav 500 tablets can be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. The appropriate dose and duration of treatment will be determined by your physician based on factors such as your age, body weight, and the specific condition being treated. It is important to follow your physician's instructions regarding the use of Furoclav 500 tablets.

Interaction

Furoclav 500 tablets may interact with certain medications and medical conditions. Here is a breakdown of the potential drug interactions and disease interactions:

Drug-Drug Interactions:

• Antacids (such as esomeprazole, and omeprazole): These medications may decrease the absorption of Furoclav 500 Tablet 7's. It is advisable to take them at least 2 hours apart.
• Anticoagulants (such as warfarin): Furoclav 500 Tablet may enhance the effects of anticoagulants, increasing the risk of bleeding. Close monitoring of blood clotting parameters is necessary.
• Anti-gout medication (probenecid): Probenecid may increase the blood levels of Furoclav 500 tablets. Your doctor may need to adjust the dosage.
• Diuretics (such as furosemide): Concurrent use of Furoclav 500 Tablet and diuretics may increase the risk of kidney damage. Regular monitoring of kidney function is important.
• Oral contraceptives (estrogen, progesterone): Furoclav 500 Tablet 6's may reduce the effectiveness of oral contraceptives. Additional contraceptive measures may be required.

Drug-Food Interactions:

• No significant interactions have been reported between Furoclav 500 Tablet and food.

Drug-Disease Interactions:

• Colitis: Furoclav 500 Tablet should be used with caution in individuals with colitis (inflammation of the colon). The medication may worsen the condition.
• Seizures: Furoclav 500 Tablet can lower the seizure threshold and may increase the risk of seizures in individuals with a history of epilepsy or a predisposition to seizures.
• Dialysis: Furoclav 500 Tablets may require dosage adjustment in individuals undergoing dialysis.
• Kidney and liver dysfunction: Furoclav 500 Tablet should be used with caution in individuals with impaired kidney or liver function. Dose adjustment may be necessary.

It is important to inform your doctor about all the medications you are taking, including over-the-counter drugs and herbal supplements, as well as any underlying medical conditions. Your healthcare provider can assess the potential interactions and adjust the treatment plan accordingly to ensure the safety and efficacy of the medications.

Contraindications

Cefuroxime-Clavulanic Acid should not be taken by individuals who have a known allergy to cephalosporin antibiotics. If you have a history of allergic reactions to cephalosporins or any other related medications, it is important to inform your doctor before taking this medication.

Additionally, Cefuroxime-Clavulanic Acid is not recommended for individuals with Pseudomembranous Colitis, which is an inflammation of the colon often caused by antibiotic use. If you have a history of this condition, it is crucial to discuss it with your healthcare provider before starting treatment with Cefuroxime-Clavulanic Acid.

Pregnancy & Lactation

Antibiotics should be avoided if at all possible throughout the first trimester. Cefuroxime-Clavulanic Acid, on the other hand, can be safely used to treat urinary and other infections later in pregnancy. Cefuroxime-Clavulanic Acid is excreted in modest amounts in breast milk. However, the possibility of the newborn being sensitized should be considered.

Precautions & Warnings

Before starting Furoclav 500 Tablet, it is important to inform your doctor about any allergies you have, especially related to antibiotics. Additionally, let your doctor know if you have kidney or liver problems. It is crucial not to take Furoclav 500 Tablet without proper medical guidance, as self-medication can contribute to antibiotic resistance, making antibiotics ineffective against specific bacterial infections.

If you have colitis (inflammation of the colon), consult your doctor before taking Furoclav 500 Tablet, as caution is advised. If you are receiving concurrent treatment with potent diuretics, it is recommended to discuss the use of Furoclav 500 Tablet with your doctor.

For pregnant women or those planning for pregnancy, it is important to consult your doctor before taking Furoclav 500 Tablet, as the medication's effects on pregnancy need to be considered. Similarly, if you are breastfeeding, it is advisable to avoid taking Furoclav 500 Tablet, as it may pass into breast milk and affect the nursing infant.

To prevent unpleasant side effects, it is recommended to avoid consuming alcohol while taking Furoclav 500 Tablets. It is important to follow these precautions and consult your healthcare provider for proper guidance and advice regarding the use of Furoclav 500 Tablet.

Storage Conditions

Store in a cool, dry place, away from light and moisture. Keep out of the reach of children.