Maxpro Mups 20mg Tablet

Uses of Maxpro Mups 20

• Gastroesophageal Reflux Disease (Acid Reflux)
• Peptic Ulcer Disease

How to use Maxpro Mups 20

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Maxpro Mups 20 is to be taken empty stomach.

How Maxpro Mups 20 works

Maxpro Mups 20 is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

Side effects of Maxpro Mups 20

• Dizziness
• Dryness in mouth
• Nausea
• Headache
• Low magnesium blood level
• Abdominal pain
• Rash on nose and cheeks
• Constipation
• Flatulence
• Diarrhea

Quick Suggestions:

• Avoid eating late at night or before bed.
• Tell your doctor if you have diarrhea, fever, or stomach pain that doesn't go away.
• Long-term use of Maxpro Mups 20 can lead to weak bones and deficiencies in minerals such as magnesium. Take a diet full of calcium and magnesium or supplements, as prescribed by your doctor.
• Consult your doctor immediately if you experience decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. This could be a sign of a kidney problem.

Indication of Maxpro Mups

Esomeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs). Maxpro Mups is used to treat certain stomach and esophagus problems (such as acid reflux, and ulcers). It works by reducing the amount of acid your stomach makes. 

Pharmacology

The H+/K+ ATPase in the gastric parietal cell is inhibited by the proton pump inhibitor esomeprazole, which reduces the amount of stomach acid produced. Esomeprazole (omeprazole's S-isomer), the first proton pump inhibitor with a single optical isomer, offers better acid control than racemic proton pump inhibitors.

Dosage & Administrations of Maxpro Mups 20

Adult:

Erosive Esophagitis-

• Adult (≥18 years): 40 mg once daily for 4 weeks.
• Children & adolescents (12-18 years): 40 mg once daily for 4 weeks.

Maintenance of healing of Erosive Esophagitis-

• Adult (≥18 years): 20 mg once daily.
• Children & adolescents (12-18 years): 20 mg once daily.

Risk reduction in NSAID-associated Gastric Ulcer-

• Adult (≥18 years): 20 mg once daily for 4-8 weeks.

H. pylori eradication (Esomeprazole MUPS tablet with 1000 mg Amoxicillin and 500 mg Clarithromycin)-

• Adult (≥18 years): 20 mg twice daily for 7 days.
• Children & adolescents (12-18 years): 20 mg twice daily for 7 days.

Zollinger-Ellison Syndrome and idiopathic hypersecretion-

• Adult (≥18 years): 40-80 mg twice daily.

Children:

Children (1-11) years:

Erosive esophagitis: 

• Weight <20 kg: 10 mg once daily for 8 weeks. Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks
• Maintenance of healing of erosive esophagitis: 10 mg once daily

Children below the age of 1 year: 

• Esomeprazole Mups tablet is not approved for use in children younger than 1 year.

Renal Dose

Renal impairment: No dosage adjustment needed.

Interaction of Maxpro Mups 20

CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Esomeprazole does not appear to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, or 3A4 in vitro or in vivo investigations. There should be no clinically significant interactions with medicines processed by these CYP enzymes. Esomeprazole has no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin, according to drug interaction studies.

Gastric acid secretion is inhibited by esomeprazole. As a result, Esomeprazole may interfere with the absorption of medications whose bioavailability is influenced by gastrointestinal pH. (e.g., ketoconazole, iron salts and digoxin).

Oral contraceptives, diazepam, phenytoin, or quinidine appear to have no effect on Esomeprazole's pharmacokinetic profile.

Clarithromycin in Combination Therapy: When esomeprazole, clarithromycin, and amoxicillin are given together, the plasma levels of esomeprazole and 14-hydroxy clarithromycin rise.

Contraindications

Esomeprazole is contraindicated in patients with known hypersensitivity to any of the formulations.

Pregnancy & Lactation

The manufacturer advises caution. It is not known if Esomeprazole or its metabolites appear in human breast milk.

Precautions & Warnings

• If the patient has severe liver failure and renal impairment, esomeprazole should be administered with caution.
• Proton pump inhibitors, such as Esomeprazole, may marginally increase the risk of hip, wrist, and spine fractures, especially when used for more than a year.

Storage Conditions

Store in a cool & dry place below 25ºC, and protect from light. Keep out of reach of children.