Maxpro 20mg Capsule 14pcs

✔️ Uses of Maxpro 20 Capsule

• Gastroesophageal reflux disease (Acid reflux)
• Peptic ulcer disease

✔️ How to use Maxpro 20 Capsule

Take Maxpro 20 in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Maxpro is to be taken empty stomach.

✔️ How Maxpro 20 Capsule works

Maxpro 20 Capsule is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

✔️ What if you forget to take Maxpro 20 Capsule?

If you miss a dose of Maxpro, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

✔️ Side Effects of Maxpro 20 Capsule

• Headache
• Dizziness
• Dryness in mouth
• Nausea
• Abdominal pain
• Constipation
• Flatulence
• Diarrhea

✔️ Quick Suggestions:

• It is a well-tolerated medication that gives long-term relief.
• Avoid eating late at night or right before going to bed.
• Inform your doctor if you have watery diarrhea, a fever, or persistent stomach pain.
• Long-term Maxpro usage can result in weak bones and a lack of minerals such as magnesium. Take calcium and magnesium supplements or calcium and magnesium supplements as directed by your doctor.
• If you experience reduced urine, edema (swelling caused by fluid retention), lower back discomfort, nausea, exhaustion, and a rash or fever, contact your doctor straight once. These symptoms might indicate renal disease.

✔️ Indications of Maxpro 20mg Capsule

Esomeprazole is not intended to provide fast relief from heartburn symptoms. Esomeprazole is a medication that is used to treat the symptoms of gastroesophageal reflux disease (GERD) and other disorders involving excess stomach acid, such as Zollinger-Ellison syndrome. Esomeprazole is also used to help repair erosive esophagitis. (damage to your esophagus caused by stomach acid).

Esomeprazole may also be used to prevent stomach ulcers caused by Helicobacter pylori infection or the use of nonsteroidal anti-inflammatory medications. (NSAIDs).

✔️ Pharmacology

The H+/K+ ATPase in the gastric parietal cell is inhibited by the proton pump inhibitor esomeprazole, which reduces the amount of stomach acid produced. Esomeprazole (omeprazole's S-isomer), the first proton pump inhibitor with a single optical isomer, offers better acid control than racemic proton pump inhibitors.

✔️ Dosage of Maxpro 20

Erosive esophagitis-

• Adult (≥18 years): 40 mg once daily for 4 weeks.
• Children & adolescents (12-18 years): 40 mg once daily for 4 weeks.

Maintenance of healing of erosive esophagitis-

• Adult (≥18 years): 20 mg once daily.
• Children & adolescents (12-18 years): 20 mg once daily.

Risk reduction in NSAID-associated gastric ulcer-

• Adult (≥18 years): 20 mg once daily for 4-8 weeks.

H. pylori eradication (Esomeprazole MUPS tablet with 1000 mg Amoxicillin and 500 mg Clarithromycin)-

• Adult (≥18 years): 20 mg twice daily for 7 days.
• Children & adolescents (12-18 years): 20 mg twice daily for 7 days.

Zollinger-Ellison syndrome and idiopathic hypersecretion-

• Adult (≥18 years): 40-80 mg twice daily.

Children 1-11 years:

Erosive esophagitis: Weight <20 kg: 10 mg once daily for 8 weeks. Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks

Maintenance of healing of erosive esophagitis: 10 mg once daily

Children below the age of 1 year: Esomeprazole Mups tablet is not approved for use in children younger than 1 year.

✔️ Administrations of Maxpro 20

Esomeprazole Capsule: should be swallowed whole and taken one hour before a meal.

✔️ Interaction of Maxpro 20

CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Esomeprazole does not appear to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, or 3A4 in vitro or in vivo investigations. There should be no clinically significant interactions with medicines processed by these CYP enzymes. Esomeprazole has no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin, according to drug interaction studies.

Gastric acid secretion is inhibited by esomeprazole. As a result, Esomeprazole may interfere with the absorption of medications whose bioavailability is influenced by gastrointestinal pH. (e.g., ketoconazole, iron salts and digoxin).

Oral contraceptives, diazepam, phenytoin, or quinidine appear to have no effect on Esomeprazole's pharmacokinetic profile.

Clarithromycin in Combination Therapy: When esomeprazole, clarithromycin, and amoxicillin are given together, the plasma levels of esomeprazole and 14-hydroxy clarithromycin rise.

✔️ Contraindications

Esomeprazole is contraindicated in patients with known hypersensitivity to any of the formulations.

✔️ Pregnancy & Lactation

In pregnant women, there are no adequate and well-controlled considerations. Teratogenic effects have not been discovered in animal studies. Esomeprazole excretion in the drain has not been studied. Breastfeeding should thus be discontinued if the use of esomeprazole is thought to be essential.

✔️ Precautions & Warnings

If the patient has severe liver failure and renal impairment, esomeprazole should be administered with caution. Proton pump inhibitors, such as Esomeprazole, may marginally increase the risk of hip, wrist, and spine fractures, especially when used for more than a year.

✔️ Storage Conditions

Store in a cool & dry place below 25ºC, and protect from light. Keep out of reach of children.