Cefaclav 250mg Tablet

Uses of Cefaclav 250

• Treatment of Bacterial Infections

Side Effects of Cefaclav 250

• Nausea
• Vomiting
• Diarrhoea
• Difficult or painful urination
• Change in taste
• Acid or sour stomach
• Abdominal discomfort or pain

How Cefaclav 250 works?

Cefuroxime and clavulanic acid are two medications included in the Cefaclav 250 Tablet. An antibiotic is Cefuroxime. It functions by halting the development of the bacterial protective coating, which is necessary for germs to survive in the human body. A beta-lactamase inhibitor called clavulanic acid prevents bacteria from producing the enzymes needed to render Cefuroxime inactive. Clavulanic Acid increases the action of Cefuroxime against microorganisms while reducing resistance.

Quick Suggestions:

• Even if the germs are resistant, this combination medication has been recommended for you to treat bacterial infections.
• Even if you feel better, do not miss any doses and complete the whole course of therapy. If you stop it too soon, the infection can return and be more difficult to cure.
• Take it with meals to prevent gastric distress.
• A side effect that might happen is diarrhea. Probiotic use may be beneficial. If you see bloody stools or get cramping in your stomach, consult your doctor.
• If you have a scratchy rash, or facial, tongue, or throat swelling while using Cefaclav 250, stop using it right away, and let your doctor know.
• Never again treat any infection with unused medication. Never use an antibiotic without first talking to your doctor.

Indications of Cefaclav 250 Tablet

Cefaclav 250 is used for the treatment of various bacterial infections such as:

• Tonsillitis or Pharyngitis
• Otitis media with bacteria in it
• Bacterial maxillary sinusitis is acute
• Pneumonia and other lower respiratory tract illnesses
• Secondary bacterial infections of acute bronchitis and acute
• Bacterial Exacerbations of chronic bronchitis
• Infected skin and skin structure
• Infections of the urinary tract
• Infected bones and joints
• Gonorrhoea (uncomplicated and disseminated gonococcal infections)
• Incipient Lyme illness (erythema migrans)
• Septicemia
• Meningitis
• After surgery, change the patient's treatment from injectable to oral when their condition has improved.

Pharmacology

A second-generation cephalosporin antibiotic called cefuroxime is bactericidal and kills a variety of Gram-positive and Gram-negative bacteria, including many strains that produce beta-lactamases. Cefuroxime prevents bacteria from producing cell walls by interfering with the transpeptidation process. A naturally occurring beta-lactamase inhibitor, clavulanic acid is created by the bacterium Streptomyces clavuligerus. Its structure is similar to that of beta-lactam antibiotics, and it binds to beta-lactamase enzymes and irreversibly inactivates them. Cefuroxime is a treatment option for bacterial infections because clavulanic acid shields it from degradation by beta-lactamase enzymes.

Dosage & Administration of Cefaclav 250 Tablet

• Adolescents and adults (13 years and older)-
• Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
• Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
• Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
• Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
• Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
• Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
• Uncomplicated Gonorrhoea: 1000 mg b.i.d. Single dose
• Community-acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
• MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
• Early Lyme disease: 500 mg b.i.d. for 20 days
• Pediatric Patients (3 months to 12 years)-
• Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
• Acute otitis media: 30 mg/kg/day b.i.d for 10 days
• Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
• Impetigo: 30 mg/kg/day b.i.d for 10 days
• The cefuroxime-Clavulanic Acid tablet may be taken without regard to food.

Interaction

Combining probenecid and cefuroxime-clavulanic acid increases the area under the serum concentration versus the time curve by 50%. Cefuroxime's bioavailability may be compromised and the effects of postprandial absorption may be counteracted by a medication that reduces stomach acidity.

Contraindications

Cefuroxime-Clavulanic Acid is not recommended for people who have a known cephalosporin allergy or who have Pseudomembranous Colitis.

Pregnancy & Lactation

If at all possible, steer clear of antibiotics during the first trimester. Contrarily, urinary and other infections can be safely treated later in pregnancy with cefuroxime-clavulanic acid. Small amounts of cefuroxime-clavulanic acid are excreted in breast milk. However, it is important to take into account the possibility of the newborn becoming sensitized.

Precautions & Warnings

Cefuroxime should be used with caution in individuals who are taking powerful diuretics and have a history of colitis.

Storage Conditions

Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.