Cefotil Plus 250 Tablet is an antibiotic consisting of (Cefuroxime Axetil 250mg + Clavulanic Acid 62.5mg). It is used to treat bacterial infections affecting the lungs, nose, throat, ears, skin, and urinary tract.
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Cefotil Plus 250 is a combination medication containing Cefuroxime and Clavulanic Acid. Cefuroxime is an antibiotic belonging to the cephalosporin group, while Clavulanic Acid is a beta-lactamase inhibitor that helps in enhancing the effectiveness of the antibiotic.
Cefotil Plus 250 is used to treat various bacterial infections, including:
Pharyngitis and/or tonsillitis
Acute bacterial otitis media
Acute bacterial maxillary sinusitis
Lower respiratory tract infections, including pneumonia and acute bacterial exacerbations of chronic bronchitis
Secondary bacterial infections of acute bronchitis
Skin and skin structure infections
Urinary tract infections
Bone and joint infections
Gonorrhea (uncomplicated and disseminated gonococcal infections)
Early Lyme disease (erythema migrans)
Switch therapy after surgery when the patient's condition improves (from injectable to oral)
Before taking Cefotil Plus 250 Tablet, it is important to inform your doctor if you have a history of colitis, liver problems, or kidney problems. The medication should be used with caution in patients who are sensitive to penicillin. It should also be used with caution in pregnant women, and it is not recommended for use in breastfeeding women.
Common side effects of Cefotil Plus 250 Tablet include nausea, vomiting, diarrhea, abdominal discomfort, or pain. If these side effects worsen or do not improve, it is advisable to consult your doctor for guidance.
As with any medication, it is important to follow your doctor's instructions and complete the full course of treatment prescribed to effectively treat the bacterial infection.
Avoid consuming alcohol while taking Cefotil Plus 250 Tablet to prevent unpleasant side effects.
CONSULT YOUR DOCTOR
Cefotil Plus 250 Tablet should be used with caution in pregnant women only if needed as there are no adequate and well-controlled studies. Consult your doctor before taking it.
Cefotil Plus 250 Tablet is not recommended for use in breastfeeding women as small traces may pass through the mother’s milk. Consult your doctor before taking it.
Dizziness has been reported during treatment with Cefotil Plus 250 Tablet and may affect the ability to drive and use machines. Consult your physician before taking Cefotil Plus 250 Tablet.
Cefotil Plus 250 Tablet should be taken with caution in patients with kidney problems. Consult your doctor for advice.
Cefotil Plus 250 Tablet should be taken with caution in patients with liver problems. Consult your doctor for advice.
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Uses of Cefotil Plus 250 Tablet
Skin And Structure Infection
How does Cefotil Plus 250 Tablet work?
Cefotil Plus 250 Tablet is a combination of cefuroxime and clavulanic acid. Cefuroxime is an antibiotic that works by preventing the formation of a protective coating on the bacteria, which is essential for their survival. Clavulanic acid is a beta-lactamase inhibitor that works by reducing resistance and enhancing the activity of cefuroxime against bacteria.
Side Effects of Cefotil Plus 250 Tablet
Difficult or painful urination
Change in taste
Acid or sour stomach
You have been prescribed this combination medicine to treat bacterial infections, even if they have developed resistance.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat.
Take it with food to avoid an upset stomach.
Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
Stop taking Cefotil Plus 250 and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while taking it.
Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.
Indication of Cefotil Plus 250 Tablet
Cefotil Plus 250 Tablet is used to treat infections caused by bacteria that are susceptible to antibiotics.
Streptococcus pyogenes causes pharyngitis and tonsillitis.
Streptococcus pneumonia, Haemophilus influenza, Moraxella catarrhalis (beta-lactamase generating strains), or Streptococcus pyogenes cause acute bacterial otitis media.
Streptococcus pneumonia, Haemophilus influenza (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, and E. coli cause lower respiratory tract infections.
Streptococcus pneumonia, Haemophilus influenza (beta-lactamase negative strains), or Haemophilus parainfluenza cause acute bacterial aggravation of chronic bronchitis and secondary bacterial infections of acute bronchitis (beta-lactamase negative strains). Staphylococcus aureus (including beta-lactamase generating strains) or Streptococcus pyogenes infections of the skin and skin structures.
E.coli or Klebsiella pneumonia infections of the urinary tract.
Staphylococcus aureus infections of the bones and joints (penicillinase- and non-penicillinase-producing strains).
Penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae cause gonorrhea.
Borrelia burgdorferi causes early Lyme Disease (erythema migrans).
Cefuroxime is a well-studied and potent antibacterial drug with broad-spectrum bactericidal activity against a variety of infections, including those that produce -lactamases. Cefuroxime is resistant to bacterial-lactamase and thus efficacious against a wide range of ampicillin- and amoxicillin-resistant strains.
Dosage & Administration of Cefotil Plus 250 Tablet
Adolescents and adults (13 years and older):
Pharyngitis/tonsillitis: 250 mg twice daily for 5-10 days
Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days
Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days
Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5-10 days
Uncomplicated skin and skin structure infections: 250-500 mg twice daily for 10 days
Uncomplicated urinary tract infections: 250 mg twice daily for 7-10 days
Uncomplicated gonorrhea: 1000 mg twice daily as a single dose
Community-acquired pneumonia: 250-500 mg twice daily for 5-10 days
MDR (multidrug-resistant) typhoid fever: 500 mg twice daily for 10-14 days
Early Lyme disease: 500 mg twice daily for 20 days
Pediatric patients (3 months to 12 years):
Pharyngitis/tonsillitis: 20 mg/kg/day divided into two doses for 5-10 days
Acute otitis media: 30 mg/kg/day divided into two doses for 10 days
Acute bacterial maxillary sinusitis: 30 mg/kg/day divided into two doses for 10 days
Impetigo: 30 mg/kg/day divided into two doses for 10 days
It's important to note that the cefuroxime-Clavulanic Acid tablet can be taken without regard to food.
As always, it's crucial to follow the dosage instructions provided by your healthcare provider and complete the full course of treatment to ensure the effective treatment of the bacterial infection.
Interaction with Lab Test
The doctor should be informed if you are undergoing Ferricyanide test during the course of this medicine.
Interaction with Medicine
Antacids such as sodium bicarbonate and aluminum hydroxide (used to treat stomach problems)
Do not use this medication if you suffer from colitis, liver disease and seizure disorders.
Cefuroxime is not recommended for people who have a Cephalosporin allergy.
Pregnancy & Lactation
Cefuroxime is classified as a pregnancy category B by the US Food and Drug Administration. However, no suitable and well-controlled studies in pregnant women have been conducted. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Human milk has been found to contain cefuroxime. When Cefuroxime is given to a nursing woman, caution should be observed.
Precautions & Warnings
Allergy and pre-existing conditions: Inform your doctor if you have any allergies, especially to antibiotics, as well as kidney or liver problems before starting Cefotil Plus 250 Tablet 6's. Also, consult your doctor if you have colitis (inflammation of the colon).
Self-medication: Avoid self-medication with Cefotil Plus 250 Tablet, as it can contribute to antibiotic resistance. Always consult your doctor before taking antibiotics.
Concurrent treatment: If you are receiving concurrent treatment with potent diuretics, use Cefotil Plus 250 Tablet 6's with caution. Inform your doctor about all the medications you are taking.
Pregnancy and breastfeeding: Consult your doctor before taking Cefotil Plus 250 Tablet 6's if you are pregnant or planning for pregnancy. Avoid taking Cefotil Plus 250 Tablet 6's if you are breastfeeding, as it may pass into breast milk.
Alcohol and tobacco: Avoid alcohol consumption while taking Cefotil Plus 250 Tablet 6's, as it may cause unpleasant side effects. Additionally, it is advised to avoid tobacco usage.
Store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.
Yes, Cefotil Plus 250 Tablet safe to use under medical supervision, however in some patients, it may show allergic reactions. Inform your doctor about all other medicines and herbal preparations you are taking.
No, taking higher than the recommended dose can lead to increased chances of side effects.
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