Aprocin 500mg Tablet 1 Strip

✔️ Benefits:

• Broad-spectrum antibacterial activity: Effective against a range of susceptible Gram-negative and some Gram-positive bacteria.
• Treats multiple bacterial infections: Can be used for selected infections involving different body systems.
• Good tissue penetration: Ciprofloxacin reaches therapeutic concentrations in several body tissues and fluids.
• Bactericidal action: Directly inhibits bacterial enzymes required for DNA replication and repair.

✔️ Directions for Use

• Take Aprocin exactly as prescribed by your doctor.
• Swallow the tablet whole with a full glass of water.
• It may be taken with or without food.
• Do not crush or chew the tablet unless specifically instructed.
• Take each dose at approximately the same time every day.
• Drink adequate fluids during treatment unless your doctor has advised fluid restriction.
• Complete the prescribed course unless your doctor tells you to stop.
• Do not take ciprofloxacin together with milk, yoghurt, or calcium-fortified juice when consumed alone.
• Avoid taking ciprofloxacin at the same time as aluminium- or magnesium-containing antacids, sucralfate, iron, calcium, or zinc supplements. These products should generally be taken at least 2 hours before or 6 hours after ciprofloxacin.

✔️ Avoid taking Aprocin 500 simultaneously with:

• Aluminium- or magnesium-containing antacids
• Sucralfate
• Iron supplements
• Calcium supplements
• Zinc supplements
• Dairy products or calcium-fortified beverages when consumed alone

Other medicines that may interact with ciprofloxacin include certain anticoagulants, antidiabetic medicines, antiarrhythmic drugs, theophylline, phenytoin, methotrexate, and medicines that prolong the QT interval.

Tizanidine must not be used together with ciprofloxacin.

Tell your doctor about all prescription medicines, over-the-counter products, and supplements you are taking.

✔️ Side Effects

Possible side effects include:

Common:

• Nausea
• Vomiting
• Diarrhoea or loose stools
• Indigestion
• Abdominal discomfort
• Headache
• Dizziness
• Rash

Other possible effects:

• Increased liver enzymes
• Joint or muscle discomfort
• Photosensitivity
• Injection-site or vein irritation with IV administration

Serious Adverse Effects

Fluoroquinolones, including ciprofloxacin, can rarely cause serious and potentially prolonged adverse effects.

Seek immediate medical attention if you develop:

• Tendon pain, swelling, or rupture
• Severe or persistent watery or bloody diarrhoea
• Severe allergic reactions
• Seizures or significant neurological symptoms
• Severe mental or behavioural changes
• Significant heart rhythm abnormalities
• Severe muscle weakness, particularly in patients with myasthenia gravis
• Symptoms of significant blood glucose disturbance

✔️ Pediatric Use

Ciprofloxacin is generally avoided in children and adolescents because of potential effects on developing joints. However, it may be used for specific serious infections when the expected benefits outweigh the potential risks.

When pediatric use is specifically indicated, dosing is based on body weight and the infection being treated. Specialist supervision is recommended.

✔️ Adult Dosage

The appropriate dose depends on the type and severity of infection, bacterial susceptibility, renal function, and the patient's clinical condition.

Oral dosage:

• Acute uncomplicated urinary tract infection: 250 mg twice daily for 3 days.
• Mild-to-moderate UTI: 250 mg twice daily for 7–14 days.
• Severe or complicated UTI: 500 mg twice daily for 7–14 days.
• Chronic bacterial prostatitis: 500 mg twice daily for 28 days.
• Lower respiratory tract infection: 500 mg twice daily for 7–14 days in mild-to-moderate infection; 750 mg twice daily for severe or complicated infection when appropriate.
• Acute sinusitis: 500 mg twice daily for 10 days when ciprofloxacin is considered appropriate.
• Skin and skin-structure infection: 500 mg twice daily for 7–14 days for mild-to-moderate infection; 750 mg twice daily for severe or complicated infection.
• Bone and joint infection: 500 mg twice daily for approximately 4–6 weeks for mild-to-moderate infection; 750 mg twice daily may be used for severe or complicated infection.
• Intra-abdominal infection: 500 mg twice daily for 7–14 days, generally as part of appropriate combination therapy.
• Infectious diarrhoea: 500 mg twice daily for 5–7 days, depending on the causative organism and clinical circumstances.
• Typhoid fever: 500 mg twice daily for 10 days where ciprofloxacin susceptibility has been confirmed or is expected.
• Uncomplicated gonococcal infection: Ciprofloxacin should only be used when susceptibility has been established because of widespread resistance.

✔️ Pregnancy and Breastfeeding

Ciprofloxacin is generally avoided during pregnancy unless the potential benefits clearly outweigh the possible risks.

Ciprofloxacin passes into breast milk. Breastfeeding mothers should consult their doctor before taking this medicine, who can assess the benefits and potential risks and determine whether an alternative treatment is more appropriate.

✔️ Aprocin should not be used in patients with:

• Known hypersensitivity to ciprofloxacin or other fluoroquinolone antibiotics.
• Previous serious adverse reactions associated with fluoroquinolones.
• Concurrent treatment with tizanidine, as ciprofloxacin can significantly increase tizanidine concentrations and cause serious adverse effects.

✔️ Renal Dose Adjustment

Dose adjustment may be necessary in patients with significant renal impairment.

• CrCl >50 mL/min: Usually no adjustment required.
• CrCl 30–50 mL/min: 250–500 mg orally every 12 hours may be used depending on the infection.
• CrCl <30 mL/min: Dose and/or dosing interval should be adjusted according to the formulation and clinical situation.
• Hemodialysis or peritoneal dialysis: Individualized dosing is required.

✔️ Use ciprofloxacin cautiously in patients with:

• Epilepsy or a history of seizures
• Central nervous system disorders
• Severe renal or hepatic impairment
• G6PD deficiency
• Myasthenia gravis
• Diabetes or a history of blood glucose abnormalities
• Existing tendon disorders
• QT prolongation or risk factors for abnormal heart rhythm
• Bradycardia or significant cardiac disease
• Uncorrected electrolyte abnormalities

✔️ Storage:

Store Aprocin Tablet in a dry place at room temperature, protected from excessive heat, moisture, and direct light.