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Tems is prescribed for:
✔ High Blood Pressure (Hypertension): Helps control essential hypertension in adults.
✔ Cardiovascular Risk Reduction: Lowers the risk of heart-related complications in individuals with:
- A history of coronary heart disease, stroke, or peripheral arterial disease.
- Type 2 diabetes with documented organ damage.
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✅ Description:
Telmisartan is a non-peptide angiotensin II receptor blocker (ARB) that prevents angiotensin II from binding to its AT1 receptors in blood vessels and adrenal glands. This results in:
✔ Relaxation of blood vessels (reducing blood pressure).
✔ Lowered aldosterone secretion, decreasing sodium and water retention.
✔ Less strain on the heart and kidneys.
Unlike ACE inhibitors, Telmisartan does not affect bradykinin levels and does not interfere with other hormone receptors or ion channels.
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✔️ Dosage & Administration
- Starting Dose: 40 mg once daily
- Dosage Range: 20-80 mg per day
- Full Effectiveness: Within 4 weeks
Can be taken with or without food
Special Considerations:
- Elderly (≥75 years): Not recommended for initial treatment.
Kidney Disease: No dosage adjustment is needed, but monitor dialysis patients closely due to the risk of low blood pressure (orthostatic hypotension).
Liver Disease: Dose adjustments may be needed; increase gradually under supervision.
🔹 Not recommended for children (effectiveness and safety not established).
✔️ Side Effects
💊 For Hypertension Patients:
- Sinus congestion (sinusitis)
- Back pain
- Diarrhea
💊 For Cardiovascular Risk Reduction:
- Leg pain due to poor circulation (intermittent claudication)
- Skin ulcers
✔️ Overdose Effects
💥 Possible symptoms include:
- Severe low blood pressure (hypotension)
- Dizziness & rapid heartbeat (tachycardia)
- Bradycardia (slow heartbeat) in some cases
- Kidney problems (increased creatinine levels, acute kidney failure)
✔️ Drug Interactions
🚫 NSAIDs (e.g., ibuprofen, aspirin): May reduce the effectiveness of Telmisartan and increase the risk of kidney problems.
🚫 Aliskiren (in diabetic patients): Avoid due to potentially serious complications.
✔️ Contraindications
Allergic reactions to Telmisartan or its ingredients.
✔️ Pregnancy & Breastfeeding
🚨 Pregnancy Risks:
First trimester: Category C (risk cannot be ruled out).
Second & third trimester: Category D (may harm the baby).
🚨 Breastfeeding: May pass into breast milk, so consult a doctor to decide whether to continue breastfeeding or stop the medication.
✔️ Precautions & Warnings
⚠ Avoid during pregnancy – Risk of harm to the baby.
⚠ Monitor closely in patients with kidney or liver disease.
⚠ Do not combine with ACE inhibitors or other ARBs (may increase risks).
✔️ Storage Conditions
Store below 30°C, away from light & humidity. Keep out of children’s reach.
