Letrozol 2.5mg Tablet 5pcs

✔️ Side Effects of Letrozol 2.5

Common:

• Hot flashes, hypercholesterolemia, fatigue, sweating, arthralgia, rash, headache, dizziness, malaise.
• Gastrointestinal disturbances: nausea, vomiting, constipation, diarrhea, abdominal pain.
• Musculoskeletal issues: osteoporosis, joint pain/stiffness, fractures.
• Edema, depression, weight gain, hypertension, vaginal bleeding.

Rare:

• Anxiety, insomnia, memory issues, somnolence, blurred vision, skin irritation, carpal tunnel syndrome, urinary tract infections, and increased liver enzymes.

✔️ Dosage & Administration of Letrozol 2.5

Adults and Elderly:

• Standard Dose: 2.5 mg once daily.
• Adjuvant/Extended Therapy: Continue for 5 years or until tumor relapse.
• Metastatic Disease: Continue until tumor progression.

Hepatic/Renal Impairment:

• No dosage adjustment is required for moderate hepatic or renal impairment (creatinine clearance ≥10 mL/min).
• Patients with severe hepatic impairment (Child-Pugh score C) require close monitoring.

Children: Not applicable.

✔️ Interaction

• Co-administration with cimetidine or warfarin does not result in clinically significant interactions.
• Letrozole is metabolized by CYP3A4 and CYP2A6, but inhibitors of these enzymes have not shown significant interactions.

✔️ Contraindications

• Hypersensitivity to Letrozole or other aromatase inhibitors.
• Pregnancy, lactation, and premenopausal women.
• Severe hepatic dysfunction.

✔️ Overdose Effects of Letrozol 2.5

• Clinical Experience: Limited data on overdosage.
• Management: Supportive care, monitoring of vital signs, and emesis induction if alert. Dialysis may be considered due to low protein binding.

✔️ Pregnancy & Lactation

• Pregnancy: Category X. Studies in animals indicate teratogenic effects and fetal toxicity. Use in pregnant women is contraindicated.
• Lactation: It is unknown if letrozole is excreted in breast milk. Due to potential adverse effects on the infant, nursing is contraindicated during therapy.

✔️ Precautions & Warnings

• Hepatic Impairment: Exercise caution in patients with moderate hepatic dysfunction.
• Renal Impairment: No dose adjustment is needed for creatinine clearance ≥10 mL/min.
• Driving/Operating Machinery: Fatigue and dizziness may impair abilities; patients should be warned.

✔️ Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.