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Rosuvastatin
A powerful statin for effective cholesterol management and cardiovascular risk reduction
Discount
Price: ৳ 58
MRP:
৳
60
3%
Off
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Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
RTV is prescribed as an adjunct to diet in the following cases:
- Primary hyperlipidemia and mixed dyslipidemia: To reduce total cholesterol (total-C), LDL-C, ApoB, non-HDL-C, triglycerides (TG), and to increase HDL-C levels.
- Hypertriglyceridemia: For lowering triglyceride levels.
- Primary dysbetalipoproteinemia (Type III).
- Homozygous familial hypercholesterolemia (HoFH): To reduce LDL-C, total-C, and ApoB levels.
- Slowing atherosclerosis progression: As part of a comprehensive lipid-lowering strategy.
- Pediatric heterozygous familial hypercholesterolemia (HeFH): For patients aged 10–17 years who haven't responded adequately to diet therapy.
- Primary prevention: To reduce the risk of myocardial infarction (MI), stroke, and arterial revascularization procedures in patients without clinically evident coronary heart disease (CHD) but with multiple cardiovascular risk factors.
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✔️ Rosuvastatin is a potent HMG-CoA reductase inhibitor, which works by:
- Increasing hepatic LDL receptor expression, enhancing LDL uptake, and breakdown.
- Suppressing hepatic VLDL production, thereby reducing VLDL and LDL particle concentrations.
✔️ Side Effects: Rtv 10
Generally well tolerated. Commonly reported effects include:
- Headache
- Muscle pain (myalgia)
- Constipation
- Weakness (asthenia)
- Abdominal pain
- Nausea
✔️ Dosage & Administration: Rtv 10
- Adults with high cardiovascular risk or very high cholesterol: 40 mg once daily.
- HoFH: Start at 20 mg/day.
- Pediatric patients (10–17 years, HeFH): 5–20 mg/day; max 20 mg.
- Asian patients: Start with 5 mg/day.
- With cyclosporine: Limit to 5 mg/day.
- With lopinavir/ritonavir or atazanavir/ritonavir: Max 10 mg/day.
- With gemfibrozil: Avoid if possible; if used, max 10 mg/day.
- Severe renal impairment (not on dialysis): Start at 5 mg/day, do not exceed 10 mg/day.
✔️ Drug Interactions:
- Cyclosporine: Increases RTV levels — max dose: 5 mg/day.
- Gemfibrozil: Avoid combination; if needed, limit RTV to 10 mg/day.
- Lopinavir/ritonavir or atazanavir/ritonavir: Limit RTV to 10 mg/day.
- Warfarin (Coumarin anticoagulants): May increase INR — monitor closely.
- Other lipid-lowering agents: Fibrates and niacin increase myopathy risk.
✔️ Contraindications:
- Known allergy to rosuvastatin or any component
- Active liver disease or persistent, unexplained liver enzyme elevations
- Pregnancy and lactation
- Women of childbearing potential not using contraception
✔️ Pregnancy & Lactation:
- Contraindicated in pregnancy and nursing.
- Women of childbearing potential should use effective contraception.
- Discontinue immediately if pregnancy occurs.
✔️ Precautions & Warnings:
- Use cautiously in elderly patients (>65 years), those with hypothyroidism, or renal impairment.
- Discontinue if creatine kinase is markedly elevated or myopathy is suspected.
- Temporarily stop during acute serious illness (e.g., sepsis, trauma, major surgery).
- Monitor liver enzymes before treatment, after 12 weeks of starting or dose adjustment, then periodically.
✔️ Storage Conditions:
- Store below 30°C, away from light and moisture.
- Keep out of reach of children
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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
