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Rosuvastatin
A powerful statin for effective cholesterol management and cardiovascular risk reduction
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✅ Description:
RTV is prescribed as an adjunct to diet in the following cases:
- Primary hyperlipidemia and mixed dyslipidemia: To reduce total cholesterol (total-C), LDL-C, ApoB, non-HDL-C, triglycerides (TG), and to increase HDL-C levels.
- Hypertriglyceridemia: For lowering triglyceride levels.
- Primary dysbetalipoproteinemia (Type III).
- Homozygous familial hypercholesterolemia (HoFH): To reduce LDL-C, total-C, and ApoB levels.
- Slowing atherosclerosis progression: As part of a comprehensive lipid-lowering strategy.
- Pediatric heterozygous familial hypercholesterolemia (HeFH): For patients aged 10–17 years who haven't responded adequately to diet therapy.
- Primary prevention: To reduce the risk of myocardial infarction (MI), stroke, and arterial revascularization procedures in patients without clinically evident coronary heart disease (CHD) but with multiple cardiovascular risk factors.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Rosuvastatin is a potent HMG-CoA reductase inhibitor, which works by:
- Increasing hepatic LDL receptor expression, enhancing LDL uptake, and breakdown.
- Suppressing hepatic VLDL production, thereby reducing VLDL and LDL particle concentrations.
✔️ Side Effects: Rtv 10
Generally well tolerated. Commonly reported effects include:
- Headache
- Muscle pain (myalgia)
- Constipation
- Weakness (asthenia)
- Abdominal pain
- Nausea
✔️ Dosage & Administration: Rtv 10
- Adults with high cardiovascular risk or very high cholesterol: 40 mg once daily.
- HoFH: Start at 20 mg/day.
- Pediatric patients (10–17 years, HeFH): 5–20 mg/day; max 20 mg.
- Asian patients: Start with 5 mg/day.
- With cyclosporine: Limit to 5 mg/day.
- With lopinavir/ritonavir or atazanavir/ritonavir: Max 10 mg/day.
- With gemfibrozil: Avoid if possible; if used, max 10 mg/day.
- Severe renal impairment (not on dialysis): Start at 5 mg/day, do not exceed 10 mg/day.
✔️ Drug Interactions:
- Cyclosporine: Increases RTV levels — max dose: 5 mg/day.
- Gemfibrozil: Avoid combination; if needed, limit RTV to 10 mg/day.
- Lopinavir/ritonavir or atazanavir/ritonavir: Limit RTV to 10 mg/day.
- Warfarin (Coumarin anticoagulants): May increase INR — monitor closely.
- Other lipid-lowering agents: Fibrates and niacin increase myopathy risk.
✔️ Contraindications:
- Known allergy to rosuvastatin or any component
- Active liver disease or persistent, unexplained liver enzyme elevations
- Pregnancy and lactation
- Women of childbearing potential not using contraception
✔️ Pregnancy & Lactation:
- Contraindicated in pregnancy and nursing.
- Women of childbearing potential should use effective contraception.
- Discontinue immediately if pregnancy occurs.
✔️ Precautions & Warnings:
- Use cautiously in elderly patients (>65 years), those with hypothyroidism, or renal impairment.
- Discontinue if creatine kinase is markedly elevated or myopathy is suspected.
- Temporarily stop during acute serious illness (e.g., sepsis, trauma, major surgery).
- Monitor liver enzymes before treatment, after 12 weeks of starting or dose adjustment, then periodically.
✔️ Storage Conditions:
- Store below 30°C, away from light and moisture.
- Keep out of reach of children
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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