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Xeldrin contains Omeprazole, a benzimidazole derivative that inhibits gastric acid secretion. It works by blocking the hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in gastric parietal cells. Following oral intake, its effect begins within an hour, peaks within two hours, and lasts up to 72 hours. Once discontinued, normal acid secretion gradually resumes within 3 to 5 days.
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✅ Description:
Xeldrin is prescribed for the treatment of:
- Gastric and duodenal ulcers
- NSAID-associated gastric and duodenal ulcers
- Prevention in patients with a history of NSAID-related ulcers
- Gastroesophageal reflux disease (GERD)
- Long-term management of acid reflux disease
- Acid-related indigestion (dyspepsia)
- Severe ulcerative reflux esophagitis
- Prevention of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Peptic ulcers caused by Helicobacter pylori infection
Note: Always use this medication under the supervision of a registered physician.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage: Intravenous Administration
- Acid aspiration prevention: 40 mg IV slowly over 5 minutes, one hour before surgery.
- Gastric ulcer, duodenal ulcer, or reflux esophagitis: When oral treatment is not possible, 40 mg IV once daily.
- Zollinger-Ellison Syndrome: Initial dose of 60 mg IV daily, adjustable as needed. If exceeding 60 mg, administer in divided doses.
✔️ Administration Instructions:
- IV Injection: Dissolve Omeprazole powder in 10 ml of sterile water and administer slowly over 2-5 minutes at a rate of 4 ml/min. Use freshly prepared solutions within 4 hours.
- IV Infusion: Dissolve the vial contents in 100 ml saline or 5% dextrose and infuse over 20-30 minutes. If using saline, the solution remains stable for 12 hours; if using dextrose, it must be used within 6 hours. Do not mix with other drugs.
✔️ Xeldrin is generally well tolerated, with mild and reversible side effects, including:
- Common: Skin rash, itching, headache, diarrhea, nausea, flatulence, abdominal pain.
- Rare: Photosensitivity, alopecia, dizziness, dry mouth, stomatitis, muscle/joint pain, peripheral edema, increased sweating, vision disturbances, and taste changes.
- Serious (but rare): Blood disorders (leukopenia, thrombocytopenia, pancytopenia), anaphylactic shock, severe liver reactions, and interstitial nephritis.
✔️ Drug Interactions
- May reduce the absorption of Ketoconazole.
- May slow the elimination of Diazepam, Phenytoin, and Warfarin, necessitating monitoring and potential dose adjustments.
- Concomitant use with Clarithromycin increases both drugs' plasma concentrations, which is beneficial for H. pylori eradication.
- No significant interactions with Theophylline, Caffeine, Propranolol, Cyclosporin, Lidocaine, and certain NSAIDs (Piroxicam, Diclofenac, Naproxen).
- Increases Digoxin bioavailability by 10%.
- Concomitant use with Clopidogrel should be avoided as it may reduce its efficacy.
✔️ Contraindications
- Hypersensitivity to Omeprazole.
- If gastric ulcer malignancy is suspected, confirm diagnosis before treatment as Omeprazole may mask symptoms and delay detection.
✔️ Pregnancy & Lactation
- Studies indicate no harmful effects on pregnancy or fetal health.
- Uncertain if Omeprazole is excreted in breast milk; breastfeeding should be discontinued if treatment is necessary.
✔️ Precautions & Warnings
- Long-term PPI use may increase the risk of osteoporosis-related fractures.
- Atrophic gastritis has been observed in prolonged use.
- Concomitant use with Methotrexate may lead to toxicity.'
- Safety in children under 18 has not been well established.
✔️ Storage Conditions
- Store in a dry place away from heat and direct light.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
