Trio Dry Powder Inhalation Capsule | 25mcg+100mcg+62.5mcg

✔️ Composition (per inhalation capsule)

Vilanterol: 25 mcg (as Vilanterol Trifenatate)

Fluticasone Furoate: 100 or 200 mcg

Umeclidinium: 62.5 mcg (as Umeclidinium Bromide)

✔️ Side Effects

COPD (≥1% incidence): Upper respiratory infections, pneumonia, bronchitis, oral thrush, headache, back pain, joint pain, flu-like symptoms, sinusitis, pharyngitis, rhinitis, taste changes, constipation, urinary infections, diarrhea, gastroenteritis, throat pain, cough, voice changes

Asthma (≥2% incidence): Pharyngitis, upper respiratory infections, bronchitis, sinusitis, urinary infections, rhinitis, flu, headache, back pain

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✔️ Drug Interactions

Strong CYP3A4 inhibitors (e.g., ketoconazole): May increase steroid and cardiovascular effects

Monoamine oxidase inhibitors / tricyclic antidepressants: Use with caution due to vascular effects

Beta-blockers: May block bronchodilation and trigger bronchospasm

Diuretics: May worsen hypokalemia or ECG changes

Other anticholinergics: Avoid concurrent use to prevent additive effects

✔️ Contraindications

Acute asthma or COPD exacerbations requiring intensive treatment

Severe hypersensitivity to milk proteins or any component of the capsule

✔️ Dosage & Administration

Important: Do not swallow the capsule; use only with the inhaler device.

Remove the capsule from the blister pack immediately before use.

Rinse your mouth with water after inhalation to reduce the risk of oral thrush.

Adults (≥18 years):

COPD: 1 capsule inhaled once daily

Asthma: 1 capsule inhaled once daily

Use at the same time each day.

For sudden symptoms, use a short-acting beta-2 agonist (SABA).

✔️ Precautions & Warnings

Do not use for acute asthma or COPD attacks

LABA monotherapy increases the risk of serious asthma events

Avoid combining with other LABA-containing treatments

Candida infections: Rinse mouth after inhalation

Pneumonia risk: Monitor COPD patients for infection

Paradoxical bronchospasm: Discontinue if it occurs

Use with caution in patients with cardiovascular disease, urinary retention, prostatic hyperplasia, convulsive disorders, thyrotoxicosis, diabetes, or ketoacidosis

✔️ Storage:

Store in a cool, dry place away from direct sunlight and heat

Keep out of reach of children

Avoid contact with eyes