Xelnib 5 Tablet 1 Strip

✔️ How does Xelnib 5 work?

Rheumatoid arthritis is an autoimmune disease characterized by a dysregulation of pro-inflammatory cytokines, including IL7, IL15, IL21, IL6, IFN-alpha, and IFN-beta. (3) Cytokine signalling results in tissue inflammation and joint damage by stimulating the recruitment and activation of immune cells via the Janus kinase signalling pathway.

Tofacitinib is a partial and reversible Janus kinase (JAK) inhibitor that will prevent the body from responding to cytokine signals. By inhibiting JAKs, tofacitinib prevents the phosphorylation and activation of STATs. The JAK-STAT signalling pathway is involved in the transcription of cells involved in hematopoiesis and immune cell function. Tofacitinib works therapeutically by inhibiting the JAK-STAT pathway to decrease the inflammatory response. However, there is evidence to suggest that it may also achieve efficacy via other pathways as well.

✔️ Side Effects of Xelnib 5

• dizziness
• respiratory infections
• increased cholesterol levels
• nausea
• diarrhea
• abdominal pain

✔️ Interaction

• Potent inhibitors of Cytochrome P450 3A4 (CYP3A4) (e.g., Ketoconazole)
• Recommended dose is Xelnib 5 mg once daily: One or more concomitant medications that result in both moderate inhibition of CYP3A4 and potent inhibition of CYP2C19 (e.g., fluconazole)
• Recommended dose is Xelnib 5 mg once daily. Potent CYP inducers (e.g., Rifampin): May result in loss of or reduced clinical response.

✔️ Pregnancy & Lactation

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Tofacitinib should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

It is not known whether Tofacitinib is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Tofacitinib, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug for the mother

✔️ Precautions & Warnings

• Serious Infections: Avoid use of Xelnib during an active serious infection, including localized infections.
• Gastrointestinal Perforations: Use with caution in patients who may be at increased risk.
• Laboratory Monitoring: Recommended due to potential changes in lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids.
• Immunizations: Live vaccines: Avoid use with Xelnib.
• Do not initiate Xelnib if absolute lymphocyte count <500 cells/mm3, an absolute neutrophil count (ANC) <1000 cells/mm3, or hemoglobin <9 gm/dL.

✔️ Storage:

Store below 30°C. Protect from light & moisture. Keep all medicines out of the reach of children.