Tofacent 5mg Tablet 10pcs

✔️ Uses of Tofacent 5mg Tablet

Tofacitinib is used in the treatment of rheumatoid arthritis.

✔️ How does Tofacent 5mg Tablet work?

Tofacent 5mg Tablet works by blocking the action of the enzyme, Janus kinase. This decreases inflammation and joint damage in rheumatoid arthritis.

✔️ Side Effects of Tofacent 5mg Tablet

• The most common adverse reactions include upper respiratory tract infection, nasopharyngitis, diarrhea, and headache.
• Reported in ≥5% of patients treated with Tofacitinib for ulcerative colitis: nasopharyngitis, elevated cholesterol levels, headache, upper respiratory tract infection, increased blood creatine phosphokinase, rash, diarrhea, and herpes zoster.

✔️ Quick Suggestions:

• Used alone or in combination with other medicines for the treatment of rheumatoid arthritis that did not improve with other anti-rheumatic drugs.
• It may take 3 to 6 months to feel the maximum effect of this medication.
• Regular blood tests may be conducted to monitor liver function, kidney function, blood counts, or cholesterol levels.
• Tofacitinib can make it a bit harder for people to fight off infections.
• Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
• A TB (tuberculosis) skin test and a chest X-ray may be done before starting treatment with this medication.
• Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

✔️ Indications of Tofacent 5mg Tablet

Tofacitinib 

• For adult patients with moderately to severely active rheumatoid arthritis who have had an insufficient response or intolerance to methotrexate.
• Can be used alone or in combination with other nonbiologic disease-modifying antirheumatic medicines like methotrexate.
• Also indicated for adult patients with active psoriatic arthritis who have had an unsatisfactory response or sensitivity to methotrexate or other disease-modifying antirheumatic medications.
• Used to treat ulcerative colitis in adults with moderately to highly active ulcerative colitis (UC).

✔️ Pharmacology

• Tofacitinib is a Janus kinase (JAK) inhibitor that prevents the body from responding to cytokine signals.
• Suppresses the phosphorylation and activation of STATs by inhibiting JAKs.
• Blocks the JAK-STAT pathway, reducing the inflammatory response.

✔️ Dosage & Administration of Tofacent 5mg Tablet

• Rheumatoid Arthritis: Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily. Recommended dosage in patients with moderate and severe renal impairment or moderate hepatic impairment is Tofacitinib 5 mg once daily.
• Psoriatic Arthritis: Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily. Recommended dosage in patients with moderate and severe renal impairment or moderate hepatic impairment is Tofacitinib 5 mg once daily.
• Ulcerative Colitis: Tofacitinib 10 mg twice daily for at least 8 weeks; then 5 or 10 mg twice daily. Discontinue after 16 weeks of 10 mg twice daily if adequate therapeutic benefit is not achieved. Use the lowest effective dose to maintain response.

✔️ Interaction

• Inhibitors: Cytochrome P450 3A4 (CYP3A4) inhibitors of high potency (e.g., Ketoconazole) may require adjustment of Tofacitinib dosage.
• Inducers: Inducers of CYP (e.g., Rifampin) may result in a lower clinical response to Tofacitinib.

✔️ Contraindications

Hypersensitivity to the active substance or to any of the excipients.

✔️ Pregnancy & Lactation

• Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Not known whether Tofacitinib is excreted in human milk. Caution is advised during lactation.

✔️ Precautions & Warnings

• Caution during active serious infections, including localized infections.
• Increased risk of gastrointestinal perforations.
• Regular laboratory monitoring is recommended for potential changes in lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids.
• Avoid live vaccines while using Tofacitinib.

✔️ Storage Conditions

Store below 30°C. Protect from light & moisture. Keep out of the reach of children.