Meth 2.5mg Tablet

Uses of Meth 2.5mg Tablet

• Choriocarcinoma
• Rheumatoid Arthritis
• Psoriasis
• Acute lymphoblastic Leukaemia (ALL) and Lymphoma

How does Meth 2.5mg Tablet work?

• Methotrexate interferes with the growth of rapidly reproducing cells, acting as an anti-tumor agent.
• It reduces undesired immune responses, serving as an immunosuppressant.
• Exhibits anti-inflammatory effects, alleviating symptoms of diseases like rheumatoid arthritis and psoriasis.

Side Effects of Meth 2.5mg Tablet

Headache, nausea, vomiting, dizziness, altered blood cell levels, sore throat, mouth and lip soreness, loss of appetite, stomach pain, infections, diarrhea, fatigue, and hair loss.

Quick Suggestions:

• Not recommended for pregnant/nursing women, those planning pregnancy, heavy alcohol consumers, and patients with liver/kidney impairment.
• Caution for patients with lung, blood, or gastric disorders.
• Avoid caffeine-containing products during treatment.
• Inform the doctor about medical/family history and other medications.
• Not recommended in children for certain conditions; caution in polyarticular juvenile idiopathic arthritis.
• Use with caution in the elderly due to reduced organ function.

Diet & Lifestyle Advise:

For Arthritis:

• Engage in physical activity like walking or swimming for 20-30 minutes daily.
• Practice yoga for joint flexibility and pain management.
• Maintain a healthy weight through regular low-strain exercises and a balanced diet.
• Ensure adequate sleep to reduce inflammation and swelling.
• Manage stress through meditation, reading, warm baths, or soothing music.
• Consider alternative therapies like acupuncture, massage, and physical therapy.
• Consume antioxidant-rich foods such as berries, spinach, and dark chocolate.
• Include flavonoid-rich foods like soy, berries, broccoli, grapes, and green tea.
• Avoid smoking and limit alcohol consumption.

For Psoriasis:

• Include cherries, berries, leafy vegetables, salmon, and omega-3-rich fish in your diet.
• Consume antioxidant-rich spices and herbs like cumin, ginger, sage, and thyme.
• Avoid processed foods, refined sugars, and fatty foods.
• Limit potential allergy-triggering foods like dairy, soy, eggs, and nuts.
• Maintain a balanced diet with fruits, vegetables, whole grains, healthy fats, and fish.
• Manage stress and prioritize a good sleep cycle.

Cancer: 

• Avoid harsh soaps, detergents, and rough fabrics.
• Maintain a healthy lifestyle by adopting a nutritious diet and engaging in regular exercise to keep your weight in check.
• Refrain from smoking and limit alcohol intake.
• Incorporate leafy greens, citrus fruits, fatty fish, berries, yogurt, apples, peaches, cauliflower, cabbage, broccoli, and beans, as well as herbs and spices into your meals.
• Steer clear of fast food, fried items, processed meats, refined carbohydrates, and added sugars.
• Ensure you get sufficient, quality sleep to rest well.

Pharmacology

Methotrexate is a folic acid antagonist that interferes with DNA synthesis. It acts by irreversibly binding to dihydrofolate reductase, an enzyme involved in the conversion of dihydrofolate to tetrahydrofolate. Tetrahydrofolate is essential for the synthesis of purines and thymidylate, which are building blocks of DNA.

By inhibiting dihydrofolate reductase, Methotrexate disrupts the production of reduced folates, ultimately leading to a decrease in the synthesis of purines and thymidylic acid. This interference with DNA synthesis is particularly relevant in rapidly dividing cells, such as cancer cells, where the drug exerts its cytotoxic effects. It is commonly used in the treatment of certain cancers and autoimmune conditions.

Dosage & Administration of Meth 2.5mg Tablet

Take as advised by the physician, usually swallowed with water. Do not crush or chew.

Interaction

• Numerous drug-drug interactions, including antibiotics, antacids, cancer drugs, pain relievers, and others.
• Avoid drinks containing caffeine to prevent dehydration.

Overdosage:

• Symptoms include easy bruising or bleeding, nausea, vomiting, weakness, mouth sores, and ulcers.

Pregnancy & Lactation

The pregnancy category X designation indicates that studies in animals or humans have revealed fetal abnormalities or demonstrated evidence of fetal risk, and the potential risks associated with the use of the drug in pregnant women outweigh any potential benefits. Consequently, drugs classified under category X are contraindicated in women who are pregnant or may become pregnant due to the high risk to fetal health. It emphasizes the importance of avoiding the use of such drugs during pregnancy to prevent harm to the developing fetus.

Precautions & Warnings

Multiple contraindications, including allergies to Methotrexate, liver disorders, kidney disorders, blood disorders, and impaired immune systems.

Storage Conditions

Keep below 25°C, out of reach of children.