Wikijet 15mg/0.5ml Pre-Filled Syringe

✔️ Recommended Dosage

• The recommended starting dose is 2.5 mg once weekly, administered by subcutaneous injection. The 2.5 mg dose is intended for treatment initiation and is not intended as a maintenance dose for glycemic control.
• After 4 weeks, the dose should generally be increased to 5 mg once weekly.
• If additional glycemic control is required, the dose may be increased in 2.5 mg increments after at least 4 weeks at the current dose.
• The maximum recommended dosage is 15 mg once weekly.
• The safety and effectiveness of Wikijet have not been established in patients under 18 years of age.

✔️ Overdose

In the event of an overdose, treatment should be based on the patient's clinical signs and symptoms. Appropriate supportive care and medical observation may be required.

Because tirzepatide has a long duration of action, symptoms following an overdose may require prolonged monitoring. Its elimination half-life is approximately 5 days.

Seek immediate medical attention if an excessive dose has been administered.

✔️ Missed Dose

If a dose is missed:

• Administer the missed dose as soon as possible within 4 days (96 hours).
• If more than 4 days have passed, skip the missed dose and take the next dose on the regularly scheduled day.
• The regular once-weekly schedule can then be resumed.

The weekly injection day may be changed if necessary, provided there are at least 72 hours (3 days) between two doses.

✔️ Side Effects

• Nausea
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation
• Dyspepsia or indigestion
• Abdominal pain

✔️ Pregnancy & Lactation

Pregnancy

Poorly controlled diabetes during pregnancy can pose risks to both the mother and fetus. Wikijet should be used during pregnancy only when the potential benefits are considered to outweigh the potential risks.

Women who are pregnant or planning pregnancy should discuss tirzepatide treatment with their healthcare provider.

Breastfeeding

The benefits of breastfeeding should be considered alongside the mother's clinical need for tirzepatide and any potential effects on the breastfed infant. Discuss the use of Wikijet with a healthcare professional before starting or continuing treatment while breastfeeding.

✔️ Wikijet is contraindicated in patients with:

• Known hypersensitivity to tirzepatide or any component of the formulation.
• A personal or family history of medullary thyroid carcinoma (MTC).
• Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

✔️ Precautions & Warnings

Risk of Thyroid Tumors

Patients should be informed about the potential risk of thyroid C-cell tumors associated with tirzepatide. Seek medical advice if symptoms such as a neck lump, difficulty swallowing, difficulty breathing, or persistent hoarseness develop.

Pancreatitis

Patients should be monitored for signs and symptoms of pancreatitis, such as persistent or severe abdominal pain that may radiate to the back, with or without vomiting.

If pancreatitis is suspected, Wikijet should be discontinued and appropriate medical evaluation and treatment initiated.

Hypoglycemia

The risk of hypoglycemia may increase when tirzepatide is used together with insulin or insulin secretagogues such as sulfonylureas. The dose of these medicines may need to be reduced under medical supervision.

Hypersensitivity

Serious allergic or hypersensitivity reactions may occur. Discontinue Wikijet and seek immediate medical attention if symptoms such as severe rash, facial or throat swelling, difficulty breathing, or other signs of a serious allergic reaction develop.

Renal Function

Monitor renal function when initiating or increasing the dose in patients with renal impairment who experience severe gastrointestinal reactions such as prolonged vomiting or diarrhea, as dehydration may affect kidney function.

Diabetic Retinopathy

Patients with a history of diabetic retinopathy should be monitored for changes or progression in their eye condition, particularly when blood glucose levels improve rapidly.

Gallbladder Disease

If symptoms suggestive of gallbladder disease occur, such as persistent upper abdominal pain, nausea, vomiting, or jaundice, appropriate clinical evaluation and gallbladder investigations may be required.

✔️ Drug Interactions

Insulin and Insulin Secretagogues

Concomitant use with insulin or insulin secretagogues such as sulfonylureas may increase the risk of hypoglycemia. Your doctor may reduce the dose of these medicines when Wikijet is initiated.

Oral Medicines

Tirzepatide delays gastric emptying, which may affect the absorption of certain oral medicines. Patients taking medicines that depend on specific blood concentrations for effectiveness or have a narrow therapeutic index, such as warfarin, may require additional monitoring.

Oral Hormonal Contraceptives

Because tirzepatide can affect gastric emptying, oral hormonal contraceptive effectiveness may potentially be reduced during treatment initiation and dose escalation.

Patients using oral hormonal contraceptives should discuss contraceptive options with their healthcare provider. A non-oral contraceptive method or an additional barrier method may be recommended for 4 weeks after starting tirzepatide and for 4 weeks after each dose increase.

Non-oral hormonal contraceptives are not expected to be affected in the same manner.

✔️ Storage:

• Store in a refrigerator at 2°C to 8°C.
• Do not freeze.
• Do not use Wikijet if it has been frozen.
• Protect from light.
• Keep out of the reach and sight of children.
• Use and dispense only according to the prescription and instructions of a registered physician.