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Numira 10 | 1 Strip | 15pcs
Mirogabalin Besylate 10
- Adults: Start with 5 mg twice daily, gradually increase by 5 mg weekly to a maximum of 15 mg twice daily. Dose may be maintained between 10–15 mg twice daily, depending on age and clinical response.
- Children/Adolescents: Safety and efficacy not established.
- Hepatic impairment: Mild to moderate – generally safe; no data for severe impairment.
Renal impairment:
- Mild: Start with 5 mg twice daily → may increase to 10 mg twice daily
- Moderate: Start with 2.5 mg twice daily → may increase to 7.5 mg twice daily
- Severe: Start with 2.5 mg once daily → may increase to 7.5 mg once daily
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বাহিরে
✅ Description:
Numira Tablet is prescribed for the management of:
- Neuropathic pain
- Diabetic peripheral neuropathic pain (DPNP)
- Postherpetic neuralgia (PHN)
- Peripheral neuropathic pain (PNP)
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Composition
Mirogabalin Besylate
✔️ Pharmacology
Mirogabalin belongs to the gamma-aminobutyric acid derivative class. It selectively binds to α2δ subunits of voltage-gated calcium channels (VGCCs), reducing calcium influx and neurotransmitter release at presynaptic nerve endings. This mechanism decreases central nervous system (CNS) hyperexcitability, thereby alleviating neuropathic pain.
Absorption: Rapid after oral administration (Tmax: 0.5–1.5 hrs)
Protein binding: ~25% (low)
Distribution volume: 64–88 L
Elimination: Mainly excreted unchanged (61–72%) via the kidneys; 13–20% metabolized by UGT enzymes
Half-life: 2–4.9 hours
Excretion: ~99% through urine, ~1% via feces
✔️ Side Effect
Common: Drowsiness, dizziness, edema, weight gain
Serious (rare):
Severe dizziness, loss of consciousness
Liver dysfunction (jaundice, nausea, fatigue, vomiting)
✔️ Drug Interaction
Cimetidine, Probenecid → may elevate plasma concentration of Mirogabalin.
Alcohol, Lorazepam → can intensify CNS depressant effects (drowsiness, impaired motor skills).
Mirogabalin is a substrate of OAT1, OAT3, OCT2, MATE1, MATE2-K, and UGT.
Does not inhibit or induce major CYP450 enzymes.
✔️ Contraindications
Hypersensitivity to Mirogabalin
Patients with mild to moderate hepatic or renal impairment
✔️ Use in Pregnancy & Lactation
- Use only if the potential benefits outweigh risks.
- Animal studies indicate placental transfer and secretion into breast milk.
- Decision on use during pregnancy or breastfeeding should be made carefully in consultation with a doctor.
✔️ Precautions & Warnings
May cause drowsiness, dizziness, blurred vision, or double vision → avoid driving or operating machinery.
Elderly patients are at increased risk of falls and fractures.
May cause weight gain with prolonged use.
Stop immediately if allergic reactions occur.
Dose adjustment required for patients with renal dysfunction.
✔️ Storage:
Store below 30°C, in a cool, dry place, away from light and moisture.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
