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Pregabalin is a chemical analogue of the inhibitory neurotransmitter GABA, but it does not directly bind to GABA or benzodiazepine receptors. Instead, it strongly attaches to the alpha2-delta subunit of voltage-gated calcium channels in the CNS. This binding is thought to mediate its pain-relieving and anti-seizure effects, although the complete mechanism is not fully understood.
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✅ Description:
Diabetic Neuropathic Pain (Adults)
IR Tablets: Start with 50 mg thrice daily (150 mg/day). Can be increased to 100 mg thrice daily (300 mg/day) as tolerated.
CR Tablets: Start at 165 mg once daily after an evening meal; may be increased to 330 mg/day within 1 week. Max: 330 mg/day.
Postherpetic Neuralgia (Adults)
IR Tablets: Begin with 75 mg twice daily or 50 mg three times daily. Dose can increase to 300 mg/day in 1 week. If inadequate relief after 2–4 weeks, may go up to 600 mg/day.
CR Tablets: Start at 165 mg once daily, increase to 330 mg once daily. If still insufficient, may go up to 660 mg/day, but only in those who tolerate 330 mg/day well.
Fibromyalgia (Adults)
Start with 75 mg twice daily (150 mg/day). May be raised to 150 mg twice daily (300 mg/day). If needed, can go up to 225 mg twice daily (450 mg/day).
Spinal Cord Injury-Related Neuropathic Pain (Adults)
Initial: 75 mg twice daily. May increase to 150 mg twice daily (300 mg/day) after 1 week. Up to 600 mg/day may be used if well tolerated and needed.
Switching from IR to CR Tablets
Match daily IR dose to the nearest CR dose (e.g., 150 mg IR → 165 mg CR).
Begin CR dosing in the evening after taking the final morning dose of IR.
Missed CR Dose
If missed after dinner, Take before bed with a snack.
If missed at bedtime: Take with breakfast the next day.
If missed after breakfast: Resume next scheduled evening dose.
- Pediatric Patients: Safety not established for most indications except partial seizures in those ≥1 month.
- Extended-release tablets: Not recommended for pediatric patients.
Pregabalin CR tablets must be swallowed whole and taken after an evening meal. Do not split, crush, or chew.
📌 Gradually discontinue over at least 1 week.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Lyca 75
- Neuropathic pain
- Epilepsy/Seizures
- Fibromyalgia
✔️ Side Effects
Adults may experience:
- Drowsiness, dizziness, dry mouth
- Blurred vision, peripheral edema
- Weight gain, difficulty concentrating
Pediatric patients (partial seizures) may also show:
- Increased appetite and weight gain
✔️ Drug Interactions
With Medications: Pregabalin has a low risk of significant drug interactions.
With Food: No clinically relevant interaction.
✔️ Contraindications
Do not use in individuals with a known allergy to pregabalin or any of its ingredients.
✔️ Use in Pregnancy & Lactation
- Pregnancy: Insufficient safety data; potential fetal risk.
- Lactation: Avoid use due to potential tumorigenicity and presence in breast milk.
✔️ Precautions & Warnings
- Discontinue immediately in case of angioedema or hypersensitivity reactions.
- May increase risk of suicidal behavior, respiratory depression (especially with CNS depressants or respiratory impairment).
- Can cause drowsiness and dizziness—avoid driving or operating heavy machinery.
- Should be withdrawn gradually to avoid rebound symptoms or seizures.
- Monitor for peripheral edema, especially when used with thiazolidinediones.
✔️ Storage
- Store below 30°C in a cool, dry place away from light and moisture.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
