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Pregabalin is a chemical analogue of the inhibitory neurotransmitter GABA, but it does not directly bind to GABA or benzodiazepine receptors. Instead, it strongly attaches to the alpha2-delta subunit of voltage-gated calcium channels in the CNS. This binding is thought to mediate its pain-relieving and anti-seizure effects, although the complete mechanism is not fully understood.
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✅ Description:
Diabetic Neuropathic Pain (Adults)
IR Tablets: Start with 50 mg thrice daily (150 mg/day). Can be increased to 100 mg thrice daily (300 mg/day) as tolerated.
CR Tablets: Start at 165 mg once daily after an evening meal; may be increased to 330 mg/day within 1 week. Max: 330 mg/day.
Postherpetic Neuralgia (Adults)
IR Tablets: Begin with 75 mg twice daily or 50 mg three times daily. Dose can increase to 300 mg/day in 1 week. If inadequate relief after 2–4 weeks, may go up to 600 mg/day.
CR Tablets: Start at 165 mg once daily, increase to 330 mg once daily. If still insufficient, may go up to 660 mg/day, but only in those who tolerate 330 mg/day well.
Fibromyalgia (Adults)
Start with 75 mg twice daily (150 mg/day). May be raised to 150 mg twice daily (300 mg/day). If needed, can go up to 225 mg twice daily (450 mg/day).
Spinal Cord Injury-Related Neuropathic Pain (Adults)
Initial: 75 mg twice daily. May increase to 150 mg twice daily (300 mg/day) after 1 week. Up to 600 mg/day may be used if well tolerated and needed.
Switching from IR to CR Tablets
Match daily IR dose to the nearest CR dose (e.g., 150 mg IR → 165 mg CR).
Begin CR dosing in the evening after taking the final morning dose of IR.
Missed CR Dose
If missed after dinner, Take before bed with a snack.
If missed at bedtime: Take with breakfast the next day.
If missed after breakfast: Resume next scheduled evening dose.
- Pediatric Patients: Safety not established for most indications except partial seizures in those ≥1 month.
- Extended-release tablets: Not recommended for pediatric patients.
Pregabalin CR tablets must be swallowed whole and taken after an evening meal. Do not split, crush, or chew.
📌 Gradually discontinue over at least 1 week.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Lyca 75
- Neuropathic pain
- Epilepsy/Seizures
- Fibromyalgia
✔️ Side Effects
Adults may experience:
- Drowsiness, dizziness, dry mouth
- Blurred vision, peripheral edema
- Weight gain, difficulty concentrating
Pediatric patients (partial seizures) may also show:
- Increased appetite and weight gain
✔️ Drug Interactions
With Medications: Pregabalin has a low risk of significant drug interactions.
With Food: No clinically relevant interaction.
✔️ Contraindications
Do not use in individuals with a known allergy to pregabalin or any of its ingredients.
✔️ Use in Pregnancy & Lactation
- Pregnancy: Insufficient safety data; potential fetal risk.
- Lactation: Avoid use due to potential tumorigenicity and presence in breast milk.
✔️ Precautions & Warnings
- Discontinue immediately in case of angioedema or hypersensitivity reactions.
- May increase risk of suicidal behavior, respiratory depression (especially with CNS depressants or respiratory impairment).
- Can cause drowsiness and dizziness—avoid driving or operating heavy machinery.
- Should be withdrawn gradually to avoid rebound symptoms or seizures.
- Monitor for peripheral edema, especially when used with thiazolidinediones.
✔️ Storage
- Store below 30°C in a cool, dry place away from light and moisture.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
