Omega-3 fatty acids | Dyslipidemia, Hypertriglyceridemia, Prophylaxis of myocardial infarction
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The omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid are long-chain n-3 polyunsaturated fatty acids, which compete with arachidonic acid for inclusion in cyclo-oxygenase and lipoxygenase pathways. Their actions include hypolipidaemic action (especially a reduction in plasma triglycerides) by reducing very-low-density lipoproteins; anti-inflammatory action, attributed to effects on leukotriene synthesis; and antiplatelet effect, attributed to effects on prostanoid synthesis, which promote vasodilatation, reduction in platelet aggregation, increased bleeding time and decreased platelet counts.
Adult Dose
Oral Hypertriglyceridaemia Adult: 4 g once daily, 2g twice daily. Secondary prophylaxis of myocardial infarction: Adult: 1 g daily.
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Child Dose
<18 years: Safety and efficacy not established
1-10% Eructation (4.9%), Infection (4.4%), Flu-like syndrome (3.5%), Dyspepsia (3.1%), Taste perversion (2.7%), Back pain (2.2%), Pain (1.8% ), Rash (1.8%) , Angina pectoris (1.3%)
Haemorrhagic disorders or those receiving anticoagulants or other drugs that have antithrombotic activity; asthmatic patients sensitive to aspirin. Monitor hepatic function in patients with hepatic impairment, especially if receiving high doses. Lactation: Not known if excreted in breast milk; use caution
Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children.
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