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Mirogabalin, a γ-aminobutyric acid derivative, selectively binds to α2δ subunits of voltage-gated calcium channels (VGCCs). This reduces calcium influx at nerve endings, limiting neurotransmitter release and decreasing neuronal hyperexcitability.
- Absorption: Rapid (Tmax 0.5–1.5h)
- Protein binding: ~25%
- Distribution volume: 64–88L
- Metabolism: Minimal hepatic metabolism (UGT pathway)
- Excretion: 99% renal (mostly unchanged)
- Half-life: 2–4.9h
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বাহিরে
✅ Description:
Migalin (Mirogabalin) Tablet
- Neuropathic Pain
- Diabetic Peripheral Neuropathic Pain (DPNP)
- Postherpetic Neuralgia (PHN)
- Peripheral Neuropathic Pain (PNP)
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Composition
Mirogabalin Besylate
✔️ Side Effects
Common: Dizziness, somnolence, edema, weight gain
Occasional: Headache, nausea, blurred or double vision
Serious (rare): Loss of consciousness, liver dysfunction (jaundice, vomiting, fatigue)
👉 Stop immediately & consult a doctor if severe reactions occur.
✔️ Dosage & Administration
Adults: Start with 5 mg twice daily, titrate by 5 mg weekly to 15 mg twice daily as tolerated.
Renal impairment: Dose adjustment required.
Children/adolescents: Safety not established.
Hepatic impairment: Mild/moderate – safe; severe – no data.
✔️ Drug & Food Interactions
Cimetidine, Probenecid ↑ Mirogabalin levels
Lorazepam → enhanced CNS depression
Use caution with OAT, OCT, MATE, UGT inhibitors
With food: No effect on absorption
With alcohol: Avoid – may worsen sedation & motor impairment
✔️ Storage ConditiContraindicationson
Known hypersensitivity to Mirogabalin
Significant renal or hepatic impairment (caution advised)
✔️ Precautions & Warnings
- May cause drowsiness, dizziness, blurred/double vision → avoid driving or operating machinery
- Elderly patients: higher risk of falls/fractures
- Pregnancy & lactation: Use only if benefits outweigh risks (passes into placenta & milk in animals)
- Monitor for allergic reactions, weight gain, and renal function
✔️ Storage:
Store below 30°C in a dry place, protected from light & moisture
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
