Stedex-C Drops

Indications of Stedex-C

Eye: In acute purulent conjunctivitis, fresh inflammation of the superficial and deeper corneal layers, and corneal ulceration, this combination is appropriate. It's also used to treat keratitis disciformis, as well as the more severe forms of post-herpetic keratitis, allergic conjunctivitis, allergic blepharitis, acute and chronic iritis, chronic anterior uveitis, and corneal injury caused by chemical or thermal burns, or foreign body penetration. In steroid-responsive inflammatory ocular disorders where a corticosteroid is needed and bacterial infection or a risk of bacterial ocular infection occurs, the combination is employed.

Ear: Otitis externa, otitis media, and chronic suppurative otitis media are all treated with this combination.

Pharmaceutical Name of Stedex-C

Navana Pharmaceuticals Ltd.

Pharmacology

A glucocorticoid is dexamethasone. Its anti-inflammatory and anti-allergic properties are beneficial. It is applied topically to the anterior region of the eye to treat inflammatory disorders. After oral treatment, dexamethasone is rapidly absorbed, having a half-life of around 190 minutes. After topical treatment to the skin and eye, sufficient absorption may occur to generate systemic effects.

Chloramphenicol is a bacteriostatic antibiotic with a broad spectrum of activity against both gram-negative and gram-positive bacteria. Chloramphenicol works as an antibacterial agent by binding to bacterial ribosomes and suppressing early bacterial protein synthesis.

Administration & Dosage

Eye:

Bacterial Conjunctivitis: The recommended dosage regimen for the treatment of bacterial conjunctivitis is 1 to 2 drops instilled into the conjunctival sac (s) every 2 hours for 2 days and 1 or 2 drops every 4 hours for the next 5(five days) while awake.

Corneal Ulcers: The recommended dosage regimen for the treatment of comeal ulcer is 2 drops in the affected eye (s) every 15 minutes for the first 6 hours then 2 drops into the affected eye(s) every 30 minutes for the remainder of first day. On the second day, instill 2 drops in the affected eye (s) hourly. On the 3 to 14 days, place 2 drops in the affected eye (s) every 4 hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.

Ear: For all infections, 2 to 3 drops every 2 to 3 hours initially. Frequency should be decreased gradually as warranted by improvement in clinical signs. Care should be taken not to discontinue therapy prematurely.

Interaction of Stedex-C

In case Chloramphenicol is retained from eye when taking anticoagulants e.g. warfarin, there may be an increment within the impact of this medication. Activity of Chloramphenicol will be hindered in case given at the same time with Phenobarbital. The helpful adequacy of Dexamethasone may be diminished with the concomitant organization of phenytoin, phenobarbitone, ephedrine and rifampicin.

Contraindications

The combination is contraindicated in epithelial herpes simplex cornealis, contagious, viral, tuberculous and other contaminations of the eye and in glaucoma. Myelosuppression amid past presentation to Chloramphenicol. Extreme touchiness to Chloramphenicol & Dexamethasone Phosphate or to any other fixings of the arrangements.

Side Effects of Stedex-C

Unfavorable responses seen with Chloramphenicol are transitory visual burning or distress and other detailed responses incorporate stinging, redness, tingling, conjunctivitis, remote body sensation, photophobia, obscured vision, dryness and eye torment. Unfavorably susceptible sensitization may happen with the nearby utilize of Chloramphenicol. Rise of intraocular weight with conceivable advancement of glaucoma, rare optic nerve harm and back subcapsular cataract arrangement.

Pregnancy & Lactation

There are no satisfactory and well-controlled considers in pregnant ladies. This medicate ought to be utilized amid pregnancy as it were on the off chance that the potential advantage legitimizes the potential hazard to the baby. Caution ought to be worked out when Chloramphenicol and Dexamethasone ophthalmic arrangement is managed to a nursing mother.

Precautions & Warnings

The plausibility of diligent contagious diseases of the cornea ought to be considered after drawn out corticosteroid dosing. Delayed utilize of steroids containing items may result in back subcapsular cataract arrangement and glaucoma with optic nerve harm. Intraocular weight checking is required. Drawn out utilize of anti-microbials may result within the excess of non-susceptible living beings, counting parasites. In case unused contaminations show up amid treatment, the medicate ought to be ceased and elective treatment ought to be foundations.

Storage Conditions

Keep in a cool and dry place, away from light & keep out of the reach of children. Do not use after 30 days of first opening.