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Mirogabalin is a novel agent for the management of neuropathic pain, including diabetic peripheral neuropathic pain (DPNP), postherpetic neuralgia (PHN), and other forms of peripheral neuropathic pain (PNP).
Mirogabalin selectively binds with high affinity to the α2δ subunits of voltage-gated calcium channels (VGCCs) in the dorsal root ganglion. This action reduces calcium influx and suppresses the release of excitatory neurotransmitters, thereby decreasing neuronal hyperexcitability and relieving neuropathic pain symptoms.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
- Adults: Start with 5 mg orally twice daily. Increase gradually by 5 mg weekly up to 15 mg twice daily, depending on response, age, and tolerance.
- Adjustments: Dose may be maintained between 10–15 mg twice daily.
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✔️ Side Effects
Common: Dizziness, somnolence, peripheral edema, weight gain
Rare but serious: Loss of consciousness, liver dysfunction (jaundice, nausea, vomiting, fatigue)
✔️ Drug Interactions
Cimetidine, Probenecid → may increase Mirogabalin plasma levels
Alcohol, Lorazepam → potentiates CNS depressive effects
Does not affect CYP450 enzymes
✔️ Contraindications
Hypersensitivity to Mirogabalin
Patients with hepatic or renal impairment (mild to moderate – contraindicated; severe – not recommended)
✔️ Precautions & Warnings
May cause drowsiness, dizziness, blurred or double vision → avoid driving or operating machinery
Elderly patients: increased risk of falls and fractures
Monitor for weight gain and hepatic function
✔️ Storage
Store below 30°C in a dry, light-protected place
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
