Domin 10mg Tablet

✔️ Uses of Domin:

• Gastric motility disorders
• Indigestion
• Nausea
• Vomiting

✔️ How to use Domin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Domin is to be taken empty stomach.

✔️ How Domin works

Domin is a prokinetic. It works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach.

✔️ What if you forget to take Domin?

If you miss a dose of Domin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

✔️ Quick Suggestions:

• Domin relieves indigestion, nausea, and vomiting.
• As directed by your doctor, Domin should be taken before meals in the dosage and time frame specified.
• Domin could make you feel groggy and sleepy. Until you are aware of how it affects you, avoid driving or engaging in any activity that needs mental attention.
• When using Domin, stay away from alcohol because Domin may make you feel excessively sleepy.
• Among the negative effects is possible to dry mouth. Regular mouthwash, improved oral hygiene, more water consumption, and sugarless confectionery may be beneficial.
• If you get a fever, watery diarrhea, or persistent stomach pain, let your doctor know.
• Without contacting your doctor, don't take Domin for more than 7 days.

✔️ Side Effects of Domin 10 mg Tablet

• Skin Rash
• Weakness
• Fatigue
• Dry Mouth
• Insomnia
• Rashes
• Diarrhoea
• Hard bowel movements
• Excessive Sweating
• Unusual Tiredness And Weakness
• Depressed Mood
• Muscle Stiffness

✔️ Indications of Domin

A set of dyspeptic symptoms that is commonly accompanied by esophagitis, gastroesophageal reflux, and delayed stomach emptying:

• Abdominal distension, upper abdominal pain, and epigastric fullness
• Early satiety, eructation, and flatulence
• Stomach contents coming back up into the mouth, either with or without heartburn
• Indigestion but no ulcers

Acute nausea and vomiting that are functional, organic, viral, nutritional, radiation- or drug-related, or migraine-related. Vomiting and nausea brought on by dopamine agonists are hallmarks of Parkinson's disease. research on radiological processes increasing the rate of barium transit during future radiological exams.

✔️ Pharmacology

The main mechanism of action of the dopamine antagonist domperidone is the blockage of dopamine receptors in the stomach's chemoreceptor trigger Zone (CTZ). Its capacity to block dopamine receptors, which control gastrointestinal motility, underlies its gastroprokinetic effect. Due to its limited blood-brain barrier penetration, domperidone has essentially little effect on dopaminergic receptors in the brain while excluding any neurologic and psychotropic side effects. Domperidone improves antral and duodenal peristalsis, reduces pylorus contraction, and restores normal upper gastrointestinal motility and tone. Domperidone also improves esophageal peristalsis and lowers esophageal sphincter pressure, which stops the regurgitation of stomach contents.

✔️ Dosage & Administration of Domin 10mg Tablet

Domin 10 mg tablet should be taken 15-30 minutes before meals and, if necessary, before retiring.

The Usual recommended oral dose of Domperidone is as follows:

Adults: 

• 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.

Children: 

• 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

Adults:

• Every 6 to 8 hours, 20 mg (2 tablets or 20 ml suspension).

Children: 

• Every 6 to 8 hours throughout the day, 0.2 to 0.4 mg/kg (2-4 ml suspension/10 kg or 0.4 to 0.8 ml pediatric drops/10 kg) body weight. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By Rectum in Suppositories:

• Adults (30 mg to 60 mg every 4 to 8 hours), including the elderly.

Children: 

• For individuals weighing 10 to 25 kg, the daily maximum rectally administered dosage is 30 mg. If necessary, the dose may be spread out over the day.

Twelve weeks is the maximal treatment time.

In Dyspeptic Symptoms:

Adults: 

• 10-20 mg every 6 to 8 hours (1-2 tablets or 10 to 20 ml solution).

Children: 

• Every 6 to 8 hours throughout the day, 0.2 to 0.4 mg/kg (2-4 ml suspension/10 kg or 0.4 to 0.8 ml pediatric drops/10 kg) body weight.

Renal Dose

Renal impairment: 

• Mild to moderate: No dosage adjustment is needed. Severe: Reduce dose to 1-2 times daily w/ prolonged treatment.

✔️ Interaction of Domin 10 mg Tablet

The risk of the hypoprolactemic effects of bromocriptine may be reduced by Domin 10mg. Antimuscarinics and opioid analgesics may reduce Domperidone's impact on Gl function. When coupled with MAO (monoamine oxidase) inhibitors, dopamine should be used with care.

✔️ Contraindications

Domin 10mg should not be administered to those with a history of drug hypersensitivity or to neonates. If there is a possibility of gastrointestinal stimulation, such as bleeding, mechanical obstruction, or perforation, Domin 10mg should not be used. Additionally, those who have a prolactin-releasing pituitary tumor should avoid it. (prolactinoma).

✔️ Pregnancy & Lactation

• In most cases, domperidone is not advised during pregnancy. There isn't a lot of information available regarding using this medication while pregnant. Only situations when the expected therapeutic benefit justifies the use of Domperidone during pregnancy should be considered. Prior to using this medication, get medical guidance.
• Domperidone is often not advised if you are nursing a baby. This medication has been found in very small quantities in breast milk. It could have unfavorable negative effects on a breastfed baby's heart. Only if your doctor deems it plainly essential may Domperidone be taken while nursing. Prior to using this medication, get medical guidance.

✔️ Precautiond & Warnings

• Due to the lack of safety and effectiveness evidence, Domin 10mg tablet is not advised for use in children under the age of 12 or who weigh less than 35 kg.
• If you develop cardiac rhythm abnormalities while taking Domin 10mg, such as palpitations, difficulty breathing, or loss of consciousness, call your doctor right once. Domperidone therapy must be discontinued.

✔️ Storage Conditions

Store below 30°C, away from light and moisture. Keep out of the reach of children and pets.