Etorix 90mg Tablet

✔️ Uses of Etorix 90mg Tablet

It is used in adults and in adolescents (aged 16 years or older) to

• Treat pain and swelling caused due to inflammation of bones and joints
• Treat pain following dental surgery

✔️ How does Etorix 90mg Tablet work?

Etorix 90mg Tablet works by blocking the release of certain chemicals (prostaglandins) in the body that causes pain, swelling, and inflammation thereby reducing pain and inflammation associated with inflammatory conditions.

✔️ Side Effects of Etorix 90mg Tablet

• Stomach pain
• Dry socket (severe pain after tooth extraction)
• Swelling of the legs or feet due to fluid retention (edema)
• Dizziness
• Headache
• Palpitations (pounding heart)
• Increased blood pressure
• Wheezing or shortness of breath
• Constipation
• Flatulence
• Gastritis (inflammation of the lining of the stomach)
• Heartburn
• Diarrhea
• Indigestion (dyspepsia)
• Nausea (feeling sick)
• Vomiting (being sick)
• Inflammation of the esophagus (food pipe)
• Mouth ulcers
• Changes in blood tests related to your liver
• Weakness
• Fatigue (tiredness)
• Flu-like illness (fever, cold, cough, or sore throat)

✔️ Quick Suggestions:

• Etorix 90mg Tablet is an anti-inflammatory medicine used to treat pain, swelling, and inflammatory conditions associated with arthritis.
• It can also be used for short-term treatment of moderate pain following dental surgery.
• It is important to take the medicine as directed by your doctor, following the prescribed dosage and duration.
• Taking Etorix 90mg Tablet with or after meals can help prevent stomach upset.
• This medication is not recommended for use in children under 16 years of age.
• It is recommended to follow a healthy diet that includes fresh fruits and vegetables, limits foods high in sugar content, stays hydrated by drinking plenty of water, quit smoking, and limits caffeine and alcohol intake.
• If Etorix 90mg Tablet is prescribed for long-term use, your doctor may monitor your liver and kidney function.
• Inform your doctor about any history of a heart attack, bypass surgery, or peripheral arterial disease before starting Etorix 90mg Tablet.
• If you are pregnant, planning to become pregnant, or breastfeeding, it is important to inform your doctor before taking Etorix 90mg Tablet.

✔️ Indication of Etorix 90mg Tablet

Etorix 90 is used to treat the symptoms of-

• A form of arthritis that affects the joints is called osteoarthritis (OA)
• Rheumatoid arthritis (RA), ankylosing spondylitis, and the discomfort and inflammatory signs and symptoms of acute gouty arthritis are examples of this type of arthritis.
• For the temporary treatment of moderate pain brought on after dental surgery.

✔️ Pharmacology

Etoricoxib is a potent, orally active COX-2 selective inhibitor when used within and much over the therapeutic dosage range. There are two isoforms of cyclooxygenase: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) (COX-2). Gastric cryoprotection and platelet aggregation are two examples of typical physiologic processes that are mediated by prostaglandins and are controlled by COX-1. Inhibition of platelet aggregation and stomach injury have both been attributed to nonselective NSAIDs that inhibit COX-1. It has been established that COX-2 is the key enzyme in the synthesis of proteinoid pain, inflammation, and fever mediators. These clinical signs and symptoms are lessened along with the risk of Gl toxicity and platelet aggregation thanks to etoricoxib's specific suppression of COX-2 (within the therapeutic dosage range). Etoricoxib caused dose-dependent inhibition of COX-2 without affecting COX-1 at doses up to 150 mg per day. Etoricoxib had no effect on the production of stomach prostaglandins.

✔️ Dosage & Administration of Etorix 90mg Tablet

Adults and adolescents over 16 years:

• Osteoarthritis: A daily dose of 30 mg is advised. In some people who don't get enough relief from their symptoms, a higher dose of 60 mg once a day might be more effective.
• 90 mg once daily is the recommended dosage for rheumatoid arthritis.
• 90 mg once daily is the recommended dosage for ankylosing spondylitis.
• For acute gouty arthritis, 120 mg once daily is advised. Etoricoxib was administered for 8 days in clinical studies for acute gouty arthritis.
• Dental surgery postoperative pain: A dose of 90 mg once daily, capped at three days, is advised.

Certain patients could need more postoperative analgesia. The shortest-term and lowest effective daily dose should be utilized because the cardiovascular hazards of etoricoxib may increase with the dose and length of exposure. Periodic reevaluations of the patient's need for symptomatic relief and response to treatment are recommended, particularly in cases of osteoarthritis.

✔️ Interaction

• Etorix 90mg Tablet may interact with several drugs, including:
• Warfarin and Aspirin: Increased risk of bleeding when taken together. Close monitoring of bleeding parameters is advised.
• Rifampicin: May decrease the effectiveness of Etoricoxib. Close monitoring of the therapeutic response is recommended.
• Methotrexate: Increased risk of methotrexate toxicity. Caution is advised, and close monitoring of methotrexate levels and potential side effects is necessary.
• Antihypertensives (Enalapril, Ramipril, Losartan, Valsartan, Minoxidil): May decrease the antihypertensive effect of these medications. Blood pressure should be monitored closely.
• Diuretics: This may reduce the diuretic effect of these medications. Close monitoring of diuretic response is recommended.
• Digoxin: Etoricoxib may increase digoxin blood levels. Monitoring of digoxin levels and signs of digoxin toxicity is necessary.
• Salbutamol: Etoricoxib may reduce the efficacy of salbutamol in relieving asthma symptoms. Additional asthma medication or adjustment of the treatment regimen may be needed.
• It's important to inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter drugs, and herbal supplements, to avoid potential interactions. They can provide personalized advice and adjust the dosage or suggest alternative medications if needed.

✔️ Contraindications

• Hypersensitivity to any of the excipients or the active ingredient
• Active peptic ulcer or active gastrointestinal (Gl) hemorrhage
• Patients who experienced allergic-like reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors, including bronchospasm, acute rhinitis, nasal polyps, angioneurotic edema, urticaria, or other symptoms.
• Lactation and pregnancy
• Severe hepatic impairment (serum albumin level of 25 g/l or Child-Pugh score of 10)
• Renal creatinine clearance is estimated to be 30 ml/min.
• Children and teenagers under the age of 16.
• Inflammatory bowel disease is a condition in which the bowels become inflamed
• Heart failure with congestive heart failure (NYHA ll-IV).
• Patients with untreated hypertension whose blood pressure is routinely more than 140/90 mmHg.
• Ischemic heart disease, peripheral artery disease, and/or a developing cerebrovascular condition.

✔️ Pregnancy & Lactation

Etoricoxib, being a COX-2 inhibitor, is not recommended for women who are trying to conceive. Its safety during pregnancy and breastfeeding has not been well-established. Etoricoxib is not known to be excreted in human milk, but lactating rats have been found to excrete it in their milk. Therefore, breastfeeding is not recommended for women taking Etoricoxib. It's important to consult with a healthcare professional for specific guidance and alternative options if you are planning to conceive or are breastfeeding while using this medication.

✔️ Precautions & Warnings

• Patients most at risk of developing a gastrointestinal problem from NSAIDs should be treated with caution, including the elderly, those using another NSAID or acetylsalicylic acid concurrently, and those having a history of gastrointestinal illness, such as ulceration and Gl hemorrhage.
• Patients with substantial cardiovascular risk factors (e.g., hypertension, hyperlipidemia, diabetes mellitus, smoking) should be treated with Etoricoxib only after careful evaluation.
• Etoricoxib use may reduce prostaglandin production and, indirectly, renal blood flow, impairing renal function. Renal function monitoring in such individuals should be explored.
• Patients having a history of heart failure, left ventricular dysfunction, or hypertension, as well as those with pre-existing edema for whatever cause, should proceed with caution.
• Patients who display liver impairment symptoms and/or signs or who have abnormal liver function test results should be continuously monitored. Etoricoxib should be terminated if signs of hepatic insufficiency emerge or if persistently abnormal liver function tests (three times the upper limit of normal) are discovered.
• Etoricoxib should be stopped as soon as a skin rash, mucosal sores, or any other symptom of hypersensitivity appears.
• The anti-inflammatory drug etoricoxib may mask fever and other signs of inflammation. Use extreme caution when using etoricoxib with oral anticoagulants such as warfarin.

✔️ Storage Conditions

Protect from light and moisture by storing at a temperature below 30°C. Keep out of children's reach.