Loxodol 8mg Tablet

✔️ How does Loxodol 8 work?

Lornoxicam belongs to the oxicam group of NSAIDs. It works primarily by inhibiting cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins involved in pain and inflammation.

By lowering prostaglandin production, lornoxicam helps reduce the sensitivity of pain receptors and decreases inflammatory symptoms such as pain and swelling.

✔️ Side Effects of Loxodol 8

NSAIDs such as lornoxicam can commonly cause gastrointestinal side effects, including:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Flatulence
• Indigestion
• Abdominal pain

More serious gastrointestinal complications may occur, including:

• Peptic ulcers
• Gastrointestinal bleeding
• Ulcer perforation
• Black, tarry stools (melena)
• Vomiting blood (hematemesis)
• Ulcerative stomatitis

✔️ Loxodol should not be used in patients with:

• Allergy or hypersensitivity to lornoxicam or any ingredient in the formulation
• Active peptic ulcer disease
• Severe liver impairment
• Severe kidney impairment
• Thrombocytopenia
• Pregnancy, particularly during the third trimester

✔️ Drug Interactions

Loxodol may interact with several medicines, potentially increasing adverse effects or reducing the effectiveness of other treatments.

• Warfarin and other vitamin K antagonists: May significantly increase the risk of bleeding.
• Cyclosporine: May increase the risk of kidney dysfunction and, rarely, acute kidney injury.
• Lithium: Lornoxicam may increase lithium levels and toxicity risk.
• Methotrexate: NSAIDs may increase methotrexate exposure and associated toxicity.
• Digoxin: Lornoxicam may increase digoxin exposure.
• Diuretics: Their effectiveness may be reduced, particularly in patients with heart failure.
• ACE inhibitors and angiotensin II receptor blockers: Their blood-pressure-lowering and kidney-related effects may be affected, especially in patients with heart failure or impaired kidney function.

Tell your doctor about all medicines, supplements, and herbal products you are taking before starting treatment.

✔️ Pregnancy and Breastfeeding

Loxodol should not be used during the third trimester of pregnancy. Its use during the first and second trimesters should also be avoided unless specifically considered necessary by a doctor because sufficient clinical safety data are unavailable.

There is insufficient information regarding the excretion of lornoxicam into human breast milk. Since animal studies indicate that it can pass into milk, its use during breastfeeding is generally not recommended.

Women undergoing fertility treatment should inform their doctor before using lornoxicam because NSAIDs may affect fertility in some women.

✔️ Use Loxodol cautiously in patients with:

• Reduced kidney function
• High blood pressure
• Heart failure
• Previous stomach or intestinal ulcers or bleeding
• Ulcerative colitis or Crohn's disease
• A tendency to bleed
• Asthma
• Systemic lupus erythematosus (SLE)
• Fertility problems or those undergoing infertility treatment

Patients should use the lowest effective dose for the shortest appropriate duration to reduce the risk of NSAID-related complications.

✔️ Storage:

• Store below 30°C.
• Protect from light and moisture.
• Keep the medicine in its original packaging.
• Keep out of reach of children.