Typhocon 0.5ml IM Injection

Prophylaxis of Typhoid fever

Administration

Should be taken on an empty stomach. Take 1 hr before meals.

Adult Dose

Oral Active immunisation against typhoid fever caused by Salmonella typhi Adult: Primary immunisation: Take 1 capsule on alternate days (day 1, 3 and 5) for a total of 3 doses; all doses should be completed at least 1 wk before potential exposure. Booster immunisation: Repeat full course of primary immunisation every 5 yr if exposure continues.

Child Dose

Oral Active immunisation against typhoid fever caused by Salmonella typhi Child: >6 yr: Primary immunisation: Take 1 capsule on alternate days (day 1, 3 and 5) for a total of 3 doses; all doses should be completed at least 1 wk before potential exposure. Booster immunisation: Repeat full course of primary immunisation every 5 yr if exposure continues.

Contraindication

Congenital and acquired immune deficiency, including treatment with immunosuppressive and antimitotic drugs, acute febrile illness and acute intestinal infection. Safety of the vaccination during pregnancy has not yet been established.

Mode of Action

Live attenuated oral vaccine; conveys active immunity via stimulation of production of endogenously produced antibodies.

Precaution

Not for treatment of typhoid fever. Vaccination may not provide full proetction thus, travellers should be advised to take all necessary precautions to avoid contact or ingestion of potentially contaminated food or water sources

Side Effect

Headache, fever, rash, abdominal pain, nausea, diarrhoea, vomiting, anaphylactic reaction, demyelinating disease, myalgia, pain, urticaria, sepsis and weakness.

Interaction

Concurrent use with antibiotics or immunoglobulins may reduce the efficacy of typhoid vaccine. Mefloquine may increase the efficacy of typhoid vaccine. May reduce the diagnostic effect of tuberculin tests. Potentially Fatal: Concurrent use with immunosuppressants may increase the adverse effects of live vaccines.