Denvar 400mg 6pcs

Indications of Denvar 400

A member of the cephalosporin family of antibiotics, Denvar 200 is used to treat a range of bacterial infections.

• When caused by sensitive strains of the identified bacteria, cefixime is approved for the treatment of the following infections:
• Urinary tract infections caused by Escherichia coli and Proteus mirabilis that are not difficult.
• Haemophilus influenza, Moraxella catarrhalis, and Streptococcus pyogenes cause otitis media.
• Streptococcus pyogenes causes pharyngitis and tonsillitis.
• Streptococcus pneumoniae and Haemophilus influenzae induce acute bronchitis and acute exacerbations of chronic bronchitis.
• Neisseria gonorrhoeae causes uncomplicated gonorrhea (cervical/urethral).

Pharmacology

Cefixime is a semisynthetic third-generation cephalosporin antibiotic for oral use. At easily obtainable plasma concentrations, it is bactericidal against a wide range of gram-positive and gram-negative bacteria. By interfering with the synthesis of the bacterial cell wall, it kills bacteria. In the presence of the Beta-lactamase enzyme, it is extremely stable. As a result, many organisms resistant to penicillins and some cephalosporins may be sensitive to Cefixime due to the presence of beta-lactamases. It is absorbed about 40% to 50% of the time, whether it is given with or without food.

Dosage & Administration of Denvar 400

The usual course of treatment is 7 days. This may be continued for up to 14 days depending on the severity of the infection.

Adult and children over 12 years: The recommended adult dose is 200-400 mg (1 to 2 capsules) daily, given either as a single dose or in two divided doses. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of Cefixime 400 mg is recommended.

Children (6 months or older): Usually 8 mg/kg/day given as a single dose or in two divided doses or may be given as follows

• ½-1 year: 75 mg daily.
• 1-4 years: 100 mg daily.
• 5-10 years: 200 mg daily.
• 11-12 years: 300 mg daily
• In typhoid fever, the dosage should be 10 mg/kg/day for 14 days.
• Children (under 6 months): The safety and efficacy of Cefixime have not been established in children aged less than 6 months.

Interaction of Denvar 400

Carbamazepine: Taking these drugs together raises the carbamazepine level. Concurrent use of warfarin and other anticoagulants raises prothrombin time.

Contraindications

It is contraindicated in hypersensitivity to Cefixime or other cephalosporins.

Side Effects of Denvar 400

In general, the medication is well tolerated. Diarrhea and stool alterations are the most common adverse effects, which are more typically associated with greater doses. Nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache, and dizziness are some of the other side effects. Rashes, pruritus, urticaria, drug fever, and arthralgia have all been described as allergic reactions. When the therapy was stopped, these effects usually decreased.

Pregnancy & Lactation

However, no suitable and well-controlled studies on pregnant women have been conducted. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Cefixime is not known to be excreted in human milk. When Cefixime is given to a breastfeeding mother, caution should be observed.

Precautions & Warnings

Individuals having a history of gastrointestinal disorders, particularly colitis, should be prescribed with caution. Patients with severe renal impairment, as well as those on continuous ambulatory peritoneal dialysis or hemodialysis, should be given the medicine with caution. Only in severe renal failure (creatinine clearance 20 ml/min) should the dosage be adjusted; in that case, a daily dose of 200 mg should not be exceeded.

Storage Conditions

Keep below 30ºC temperature, protected from light & moisture. Keep out of the reach of children.