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Exiben Powder for Suspension
Exiben (Cefixime trihydrate) is an orally active cephalosporin antibiotic with bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It is indicated for the treatment of acute infections caused by susceptible microorganisms, including:
- Upper Respiratory Tract Infections (URTI), e.g., otitis media
- Other URTI where the causative organism is known or suspected to be resistant to other antibiotics
- Lower Respiratory Tract Infections, e.g., bronchitis
- Urinary Tract Infections, e.g., cystitis, cystourethritis, pyelonephritis
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✅ Description:
Exiben is an antibiotic from the cephalosporin group used to treat various bacterial infections. It is effective against respiratory tract infections, urinary tract infections, ear infections, sinus infections, throat infections, and certain sexually transmitted diseases. Exiben can be taken with or without food, but it should be taken regularly at evenly spaced intervals as prescribed by the doctor. Completing the full course is crucial, even if symptoms improve before completion. It doesn't work against viral infections like flu or the common cold.
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✔️ Uses of Exiben
- Pneumonia, Pharyngitis, Typhoid fever, Susceptible infections, Sinusitis, Otitis media, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Gonococcal urethritis, Acute bronchitis.
✔️ How Exiben works?
- Inhibits bacterial cell wall formation, leading to bacterial cell death.
✔️ Side Effects of Exiben
- Nausea
- Stomach pain
- Indigestion
- Diarrhea
✔️ Quick Suggestions:
- Take Exiben regularly and complete the full course.
- Take with food to avoid an upset stomach.
- Diarrhea may occur, but it should stop after completing the course.
- Avoid alcohol during Exiben treatment.
- Discontinue and inform your doctor if you experience rash, itching, swelling, or difficulty breathing.
✔️ Pharmacology
- Cefixime is a third-generation semisynthetic cephalosporin antibiotic.
- Bactericidal against a broad spectrum of gram-positive and gram-negative bacteria.
- Interferes with the synthesis of the bacterial cell wall.
- Highly stable in the presence of Beta-lactamase enzymes.
✔️ Dosage & Administration of Exiben
Administration:
- May be taken with or without food. May be taken with food or milk to reduce GI discomfort.
Adult Dose:
- Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections Adult: 200 or 400 mg daily as a single dose or in two divided doses. Gonorrhea: 400 mg as a single dose. Typhoid fever: 20 mg/kg body weight daily in two divided doses. The usual treatment is 7 days, up to 14 days for severe infections.
Child Dose:
- Varies with age and condition. Typically, 8 mg/kg/day if <50 kg q12–24h. Typhoid Fever: 15-20 mg/kg/day PO divided q12hr for 7-14 days; not to exceed 400 mg/day.
Renal Dose:
- Dose reduction is necessary for renal impairment. Max: 200 mg daily if CrCl <20 ml/min.
✔️ Interaction
- Increases in prothrombin times were noted in some patients.
- Caution is advised in patients receiving anticoagulant therapy.
✔️ Contraindications
Known hypersensitivity to cephalosporin antibiotics.
✔️ Pregnancy & Lactation
- Limited data; use during pregnancy only if needed.
- Not known if Cefixime is excreted in human milk; caution during lactation.
✔️ Precautions & Warnings
- Administer with caution to patients hypersensitive to other drugs.
- Use cautiously in penicillin-sensitive patients due to partial cross-allergenicity.
- Caution in patients with markedly impaired renal function.
- Avoid in pregnancy or nursing mothers unless essential.
✔️ Storage Conditions
- Keep below 30ºC, protected from light and moisture.
- Keep out of the reach of children.
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