Afix Powder for Suspension | 50ml

✔️ Side Effects: Cefixime

• Diarrhea
• Nausea
• Abdominal or stomach pain
• Indigestion
• Vomiting
• Flatulence

✔️ Adult Dose | Cefixime Trihydrate 100 mg/5 ml

Acute Bronchitis, Acute Exacerbation of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis and Uncomplicated UTI

Adults: 200–400 mg daily, either as a single dose or divided into two doses, according to the infection and doctor's prescription.

Gonorrhea

400 mg as a single oral dose may be used for uncomplicated gonococcal urethritis when appropriate.

Typhoid Fever

The dose may be approximately 20 mg/kg/day, divided into two doses. Treatment is commonly given for around 7 days and may be extended up to 14 days depending on the severity and clinical response.

The exact antibiotic regimen should be selected according to the infection, bacterial susceptibility, patient characteristics, and local treatment guidelines.

✔️ Child Dose | Cefixime Trihydrate 100 mg/5 ml

For children, dosing is generally based on body weight.

• Children: approximately 8 mg/kg/day, given once daily or divided into two doses.
• In selected serious infections, higher doses may be prescribed by a specialist.
• Children over 12 years or weighing ≥50 kg: adult dosing may be used when appropriate.
• For pediatric suspension, the dose should be measured accurately using the supplied measuring device.

Typhoid Fever in Children

Approximately 15–20 mg/kg/day, divided into two doses, may be used for 7–14 days, according to medical advice. The maximum daily dose should not exceed the recommended adult dose.

Children below 6 months: Safety and effectiveness have not been adequately established, and use should be determined by a pediatrician.

✔️ Renal Dose | Cefixime Trihydrate 100 mg/5 ml

Dose adjustment may be necessary in patients with significant renal impairment.

For severe renal impairment, such as creatinine clearance below 20 mL/min, the maximum dose may need to be reduced to approximately 200 mg/day, depending on the clinical situation.

Patients with kidney disease should use cefixime only according to medical advice.

✔️ Afix should not be used in patients with:

• Known hypersensitivity to cefixime or other cephalosporin antibiotics
• Previous serious allergic reaction to beta-lactam antibiotics, unless specifically evaluated by a physician

✔️ Use Afix cautiously in patients with:

• Previous allergy to penicillins or other beta-lactam antibiotics
• Kidney impairment
• Gastrointestinal disease
• Previous antibiotic-associated colitis
• Severe or persistent diarrhea

Prolonged antibiotic therapy may promote the overgrowth of non-susceptible organisms, including fungi. If a secondary infection develops, appropriate treatment should be considered by the physician.

Afix should be used only when a bacterial infection is suspected or confirmed to reduce unnecessary antibiotic exposure and antimicrobial resistance

✔️ Pregnancy & Lactation

Available clinical experience with cephalosporin antibiotics, including cefixime, has not established an increased risk of major birth defects or miscarriage. However, Afix should be used during pregnancy only when prescribed by a healthcare professional.

It is not fully established how much cefixime passes into human breast milk. Breastfeeding patients should consult their doctor before using Afix, who will weigh the benefits of treatment against any potential risk to the infant.

✔️ Afix may interact with certain medicines:

• Probenecid: May increase cefixime concentrations.
• Anticoagulants: Cefixime may increase prothrombin time and may enhance the effect of anticoagulant therapy in some patients.

✔️ Storage:

• Store according to the manufacturer's instructions.
• Keep in a dry place away from excessive heat and moisture.
• Protect from direct light.
• Keep out of reach of children.
• Do not use after the expiry date.