Afix 200mg Tablet 1 Strip

✔️ Drug Interaction

Cefixime, like other cephalosporins, may occasionally affect prothrombin time. Patients taking anticoagulant medicines should therefore inform their doctor and may require appropriate monitoring.

Tell your healthcare provider about all medicines, supplements, and herbal products you are taking before starting cefixime.

✔️ Dosage & Administration

Take Afix exactly as prescribed by your doctor. The usual treatment duration is around 7 days, although treatment may be extended up to 14 days when clinically necessary.

Adults and Children Over 10 Years

The usual recommended dose is 200–400 mg per day, depending on the severity and type of infection. It may be administered as a single daily dose or in two divided doses.

Children

The usual pediatric dose is 8 mg/kg/day, given either once daily or in two divided doses.

For cefixime suspension, the following may be used as general dosing guides:

• 6 months to 1 year: 3.75 mL once daily
• 1–4 years: 5 mL once daily
• 5–10 years: 10 mL once daily

The exact dose should be determined according to the child's body weight, infection, and medical condition.

Typhoid

For children with typhoid fever, a commonly recommended regimen is 5 mg/kg twice daily for 10–14 days, under medical supervision.

Children Over 50 kg or Above 10 Years

Children weighing more than 50 kg or those older than 10 years may generally receive the adult dose of 200–400 mg daily, depending on the severity of infection.

Children Under 6 Months

The safety and effectiveness of cefixime have not been adequately established in infants younger than 6 months. Use should therefore be based on specialist medical advice.

Dose in Renal Impairment

Cefixime can be used in patients with impaired kidney function, but dose adjustment may be necessary.

• Creatinine clearance ≥20 mL/min: The usual dose and schedule may generally be used.
• Creatinine clearance <20 mL/min: The dose should generally not exceed 200 mg once daily.
• Patients receiving hemodialysis or chronic ambulatory peritoneal dialysis should generally follow the dosing recommendations used for patients with creatinine clearance below 20 mL/min.

Renal function should be assessed before and during treatment when clinically appropriate.

✔️ Common Side Effects

Afix is generally well tolerated, and most adverse effects are mild and temporary.

Possible side effects include:

• Diarrhea
• Changes in stool consistency
• Nausea
• Abdominal pain
• Indigestion
• Vomiting
• Flatulence
• Headache
• Dizziness
• Skin rash
• Itching
• Hives (urticaria)
• Drug-related fever
• Vaginal itching or vaginitis

Diarrhea may occur more frequently with higher doses.

Serious or Less Common Side Effects

Rare or clinically significant reactions may include:

• Severe allergic reactions, including anaphylaxis
• Antibiotic-associated diarrhea or pseudomembranous colitis
• Thrombocytopenia
• Leukopenia
• Eosinophilia
• Temporary changes in liver-function tests
• Temporary changes in kidney-function tests

✔️ Pregnancy & Lactation

Pregnancy: Adequate and well-controlled studies of cefixime in pregnant women are limited. It should be used during pregnancy only when clearly indicated and when the expected benefit outweighs potential risk.

Breastfeeding: It is not clearly established whether cefixime is excreted into human breast milk. A breastfeeding woman should consult her doctor before using Afix.

✔️ Storage:

• Store below 30°C.
• Protect from light and moisture.
• Keep out of reach and sight of children.
• Store the medicine in its original packaging unless otherwise directed.