Myocor 2.5 | 1 Strip

✔️ Dosage & Administration:

Adults: For mild to moderate hypertension, the recommended starting dose is 5 mg once daily, either alone or with a diuretic. If the response is inadequate, the dose may be gradually increased to 10 mg or up to 20 mg once daily at 2-week intervals. Doses above 20 mg offer limited additional benefit.

Children: Safety and efficacy in children have not been established.

Renal or Hepatic Impairment: Patients with renal (creatinine clearance <40 mL/min) or hepatic dysfunction should start with 5 mg daily. Dose adjustments should be made cautiously due to potential accumulation. Bisoprolol is not dialyzable, so replacement after dialysis is unnecessary.

Elderly: Dose adjustments are generally unnecessary unless significant hepatic or renal impairment is present.

✔️ Side Effects

• Dizziness or fatigue
• Headache
• Slow heartbeat
• Breathing difficulty
• Cold hands and feet

✔️ Drug Interactions:

• Other β-blockers: Concomitant use with other β-blockers is contraindicated.
• Catecholamine-depleting drugs (e.g., reserpine, guanethidine): May cause excessive sympathetic suppression; close monitoring is required.
• Centrally acting antihypertensives (e.g., clonidine): Beta-blockers may worsen rebound hypertension if clonidine is withdrawn abruptly. Taper the beta-blocker before discontinuing clonidine.
• Antiarrhythmics & Calcium Channel Blockers (e.g., verapamil, diltiazem): May increase the risk of bradycardia, AV block, or severe hypotension, especially in patients with cardiac conduction disorders.

✔️ Contraindications:

Myocor should not be used in patients with cardiogenic shock, overt heart failure, second or third-degree AV block, sinus bradycardia, or right ventricular failure secondary to pulmonary hypertension.

✔️ Pregnancy & Lactation

Pregnancy: Animal studies indicate no teratogenicity but show fetotoxicity at high doses. Use only if potential benefits outweigh the potential risks.

Lactation: Trace amounts have been detected in animal milk; human excretion is unknown. Discontinue breastfeeding if treatment is necessary.

✔️ Precautions & Warnings

Use cautiously in patients with impaired hepatic or renal function.

Beta-blockers may mask hypoglycemia symptoms in diabetic patients.

Patients with a history of severe anaphylaxis may be less responsive to epinephrine while on Bisoprolol.

✔️ Storage

Keep in original packaging in a cool, dry place, away from children and pets.