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Lopo Tablet | Losartan Potassium
Hypertension:
Lopo Tablet is indicated for the management of high blood pressure. It may be used alone or in combination with other antihypertensive agents such as thiazide diuretics.
Renal Protection in Type 2 Diabetes with Proteinuria:
Lopo is indicated to slow the progression of renal disease in hypertensive type-2 diabetic patients with proteinuria (urinary albumin-to-creatinine ratio >300 mg/g)
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Price: ৳ 98
MRP:
৳
100
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Cash on Delivery - All over Bangladesh
Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Usual Adult Dose: 50 mg once daily.
- If response is inadequate: 25 mg twice daily may be used before increasing the total dose.
Dose Range: 25–100 mg per day (in one or two divided doses).
Intravascular Volume Depletion (e.g., from high-dose diuretics): Start with 25 mg once daily.
Elderly (up to 75 years): No dose adjustment needed.
Over 75 years: Start with 25 mg once daily due to limited clinical data.
Renal Impairment:
Mild (CrCl 20–50 ml/min): No adjustment needed.
Moderate to severe (CrCl <20 ml/min) or dialysis: Start with 25 mg once daily.
Hepatic Impairment: Use lower doses due to higher plasma levels in cirrhotic patients.
May be administered with or without food, alone or with other antihypertensives.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ How does Losartan Potassium work?
Losartan Potassium is the first non-peptide, orally active angiotensin II receptor blocker (ARB). It selectively binds to the AT₁ receptor located in various tissues such as vascular smooth muscle, adrenal glands, kidneys, and heart, thereby blocking the effects of angiotensin II.
This action leads to vasodilation, reduced aldosterone secretion, and ultimately lower blood pressure, providing effective control of hypertension and renal protection.
✔️ Side Effects
- Dizziness
- Diarrhea
- Cough
- Nasal congestion
- Upper respiratory tract infection
✔️ Drug Interactions
- Rifampicin and Fluconazole: May reduce plasma levels of Losartan’s active metabolite, decreasing efficacy.
- Hydrochlorothiazide: May enhance the antihypertensive effect of Losartan.
- Potassium-Sparing Diuretics (e.g., Spironolactone, Triamterene, Amiloride), Potassium Supplements, or Salt Substitutes: May cause hyperkalemia (increased potassium levels).
- NSAIDs (e.g., Indomethacin): May reduce the antihypertensive effect.
- Concurrent use with ACE inhibitors, ARBs, NSAIDs, and Thiazide Diuretics: Increases the risk of renal impairment.
- Aliskiren: Should not be used with Losartan in patients with diabetes due to the risk of renal dysfunction.
✔️ Contraindications
- Hypersensitivity to Losartan or any component of the formulation.
- Pregnancy (especially the second and third trimesters).
- Concomitant use with Aliskiren in diabetic patients.
✔️ Pregnancy & Lactation
Pregnancy Category D: Losartan can cause fetal renal impairment and increase the risk of fetal and neonatal morbidity or death if used during the second or third trimester.
It is unknown whether Losartan is excreted in human milk; due to potential adverse effects on the nursing infant, the drug should be avoided during breastfeeding or discontinued if necessary.
✔️ Precautions & Warnings
- Use during pregnancy may cause fetal toxicity — discontinue immediately if pregnancy is detected.
- Volume-depleted patients (e.g., on high-dose diuretics) may experience symptomatic hypotension.
- Cirrhotic patients may have elevated plasma levels; dose adjustment may be required.
- Monitor renal function, as renal impairment or failure may occur, especially in patients with pre-existing kidney disease.
✔️ Storage:
Keep in a dry place away from light and heat. Keep out of the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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