Ancor 5mg Tablet 10pcs

✔️ Uses of Ancor 5mg Tablet

Treats:

• High blood pressure (Hypertension)
• Angina pectoris (Chest pain)
• Stable heart failure (in combination with other medicines)

✔️ How does Ancor 5mg Tablet work?

Bisoprolol is a beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood around the body.

✔️ Side Effects of Ancor 5mg Tablet

Possible side effects include:

• Common: Fatigue, dizziness, headache, gastrointestinal disturbances (nausea, vomiting, diarrhea, constipation, abdominal pain), cold or numb extremities, muscle weakness, or cramps.
• Serious: Bronchospasm (in asthmatics or COPD patients), slower than normal heart rate, breathing difficulties.

✔️ Quick Suggestions:

• Ancor is not recommended for the emergency treatment of hypertensive crises.
• Ancor 5 mg Tablet can hide symptoms of low blood sugar if you are diabetic. Monitor your blood sugar levels regularly.
• Do not stop taking Ancor 5 mg Tablet suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.

✔️ Indication of Ancor 5mg Tablet

Ancor is indicated for:

• Hypertension
• Angina
• Moderate to Severe Heart Failure

✔️ Pharmacology

Bisoprolol Fumarate is a highly selective β1-blocker with minimal effects on β2 receptors. It works by selectively blocking β1-adrenergic receptors in the heart and vascular smooth muscle, reducing heart rate and cardiac output, thus lowering arterial hypertension. Unlike non-β1 selective blockers, Bisoprolol does not adversely affect lipid metabolism or reduce cardioprotective HDL-cholesterol in long-term therapy.

Key Pharmacokinetic Properties:

• Absorption and Bioavailability: Bisoprolol is over 90% absorbed from the gastrointestinal tract with an absolute bioavailability of 88%. Food does not affect its absorption.
• Distribution: Extensively distributed with a mean distribution volume of 3.5 L/kg.
• Metabolism: Metabolized via oxidative pathways, primarily by CYP3A4, with minor involvement of CYP2D6. Metabolites are renally excreted and pharmacologically inactive.
• Elimination: Equally cleared via renal excretion and hepatic metabolism. The elimination half-life is 10-12 hours.

✔️ Dosage & Administration of Ancor 5mg Tablet

Adults:

• Initial Dose: 5 mg once daily, can be added to a diuretic or used alone.
• Titration: If 5 mg is inadequate, increase to 10 mg, and if necessary, to 20 mg once daily. Dosage increases should occur at 2-week intervals.
• Max Dose: Generally, doses beyond 20 mg once daily provide minimal additional benefit.

Children: Safety and effectiveness have not been established.

Renal or Hepatic Impairment:

• Initial Dose: 5 mg daily. Use caution in dose titration due to possible drug accumulation.
• Dialysis: Bisoprolol is not dialyzable; thus, drug replacement is not required.

Geriatrics: No dose adjustment is usually necessary unless significant renal or hepatic dysfunction is present.

Note: Always follow the prescribed regimen by a healthcare provider.

✔️ Interaction

• Other β-Blocking Agents: Do not combine with other β-blockers.
• Catecholamine-Depleting Drugs: Monitor closely as bisoprolol may excessively reduce sympathetic activity.
• Centrally Active Antihypertensive Agents: Gradually withdraw β-blockers before discontinuing clonidine to avoid rebound hypertension.
• Antiarrhythmic Agents: Use with caution when combined with myocardial depressants or inhibitors of A-V conduction (e.g., verapamil, diltiazem, disopyramide).
• Calcium Channel Blockers: Combined use can prolong S-A and A-V conduction, leading to severe hypotension, bradycardia, and cardiac failure.

✔️ Contraindications

• Cardiogenic Shock
• Overt Heart Failure
• Second or Third-Degree A-V Block
• Right Ventricular Failure secondary to Pulmonary Hypertension
• Sinus Bradycardia

✔️ Pregnancy & Lactation

• Pregnancy: Animal studies showed no teratogenic effects, but there were some fetotoxic and maternotoxic effects at high doses. Use during pregnancy only if the potential benefit justifies the risk.
• Lactation: Small amounts detected in animal milk; unknown if excreted in human milk. If necessary, mothers should stop nursing.

✔️ Precautions & Warnings

• Renal or Hepatic Impairment: Adjust doses cautiously.
• Severe Anaphylactic Reactions: Patients may be more reactive and less responsive to usual doses of epinephrine.
• Hyperoxaluria: Use vitamin C with caution.
• Anticoagulant Therapy: Vitamin E may enhance the anticoagulant effect.

✔️ Storage Conditions:

Store in a dry place below 30˚C. Protect from light and heat. Keep out of reach of children.