Nexum Mups 40mg 6pcs

Indications of Nexum Mups 40

A medication called Nexum MUPS 40 lowers the amount of acid your stomach produces. Heartburn, acid reflux, and issues with your food pipe are all treated with it. Stomach ulcers can also be prevented and treated with them. You must take Nexum MUPS 20 as directed by your physician.

Pharmacology of Nexum Mups 40

A proton pump inhibitor called Nexum MUPS 40 blocks the H+/K+ ATPase in the gastric parietal cell, which reduces the amount of stomach acid produced. Esomeprazole (omeprazole's S-isomer), the first proton pump inhibitor with a single optical isomer, offers better acid control than racemic proton pump inhibitors.

Dosage & Administration of Nexum Mups 40

Erosive esophagitis-

• Adult (≥18 years): 40 mg once daily for 4 weeks.
• Children & adolescents (12-18 years): 40 mg once daily for 4 weeks.

Maintenance of healing of erosive esophagitis-

• Adult (≥18 years): 20 mg once daily.
• Children & adolescents (12-18 years): 20 mg once daily.

Risk reduction in NSAID-associated gastric ulcer-

• Adult (≥18 years): 20 mg once daily for 4-8 weeks.

pylori eradication (Esomeprazole Mups tablet with 1000 mg Amoxicillin and 500 mg Clarithromycin)-

• Adult (≥18 years): 20 mg twice daily for 7 days.
• Children & adolescents (12-18 years): 20 mg twice daily for 7 days.

Zollinger-Ellison syndrome and idiopathic hypersecretion-

• Adult (≥18 years): 40-80 mg twice daily

Children 1-11 years:

Erosive esophagitis: Weight <20 kg: 10 mg once daily for 8 weeks. Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks

Maintenance of healing of erosive esophagitis: 10 mg once daily

Children below the age of 1 year: Esomeprazole MUPS tablet is not approved for use in children younger than 1 year.

Interaction of Nexum Mups 40

CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Esomeprazole does not appear to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, or 3A4 in vitro or in vivo investigations. There should be no clinically significant interactions with medicines processed by these CYP enzymes. Esomeprazole has no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin, according to drug interaction studies.

The primary Esomeprazole metabolizing enzyme, CYP2C19, may be harmed by Esomeprazole. The combination of Esomeprazole 30 mg and diazepam, a CYP2C19 substrate, resulted in a 45 percent reduction in diazepam clearance. Increased diazepam plasma levels have been reported up to 12 hours following treatment. Gastric acid secretion is inhibited by esomeprazole. As a result, Esomeprazole may interfere with the absorption of medicines whose bioavailability is influenced by stomach pH. (e.g., ketoconazole, iron salts and digoxin).

Contraindications

In patients who have a history of hypersensitivity to any of the formulations, esomeprazole is not recommended.

Side Effect of Nexum Mups 40

When compared to short-term treatment, there is no change in the kinds of linked adverse events reported with maintenance treatment up to 12 months.

• Headache
• Dizziness
• Dryness in mouth
• Nausea
• Abdominal pain
• Constipation
• Flatulence
• Diarrhea all are the most common side effect reported with Esomeprazole.

Pregnancy & Lactation

Caution is advised by the manufacturer. Esomeprazole or its metabolites are not known to occur in human breast milk.

Precautions & Warnings

If the patient has significant liver failure and renal impairment, esomeprazole should be taken with caution. Proton pump inhibitors, such as Esomeprazole, may modestly increase the risk of hip, wrist, and spine fractures, especially when used for more than a year.

Storage Conditions

Store in a dry location at a temperature of not more than 25°C. Light and dampness should be avoided. Keep out of children's reach.