Paracetamol produces analgesic and antipyretic effects primarily through action in the central nervous system. It relieves pain by inhibiting the formation of pain-producing prostaglandins and raising the pain threshold. Its fever-reducing action occurs through inhibition of the hypothalamic heat-regulating center, promoting heat loss through vasodilation and sweating.
Unlike NSAIDs, paracetamol has very weak peripheral anti-inflammatory activity because it does not significantly inhibit cyclooxygenase enzymes in peripheral tissues. Evidence suggests that paracetamol acts mainly on central COX enzymes, including a possible variant known as COX-3.
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Proper Packaging
Longpara is indicated for the relief of:
Adults & children above 12 years:
2 tablets every 6–8 hours
Maximum: 6 tablets in 24 hours
Tablets should be swallowed whole.
Pediatric Use
Safety and efficacy of IV paracetamol are established in children aged 2 years and older.
Geriatric Use
No major differences in safety or effectiveness have been observed in elderly patients.
Hepatic Impairment
Use cautiously in hepatic disease. Dose reduction may be required.
Renal Impairment
In severe renal impairment (CrCl <30 mL/min), longer dosing intervals and reduced daily doses may be necessary.
Longpara is contraindicated in patients with known hypersensitivity to paracetamol or any component of the formulation.
Studies have shown no harmful effects when paracetamol is used at recommended doses during pregnancy. However, it should be used according to physician's advice.
Paracetamol passes into breast milk in very small amounts and is generally considered safe during breastfeeding.
Store below 25°C in a dry place away from heat and direct light. Keep out of reach of children.
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