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Prostanil MR 0.4mg Capsule 6pcs
Prostanil MR is an alpha-blocker used to treat benign prostatic hyperplasia (BPH). It relieves symptoms like difficulty urinating but doesn’t shrink the prostate. Take it as prescribed, with food, and swallow the capsule whole—no crushing or chewing!
Prostanil MR relaxes muscles around the bladder and prostate, making it easier to urinate. It provides quick relief, with full effects seen within 2 weeks.
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✅ Description:
Tamsulosin is a selective alpha-1 adrenoceptor blocker that primarily targets alpha-1A adrenoceptors in the prostate and bladder neck. Relaxing smooth muscles, it improves urine flow and reduces symptoms of benign prostatic hyperplasia (BPH).
Safety Advices
Alcohol
UNSAFE
Prostanil MR can cause excessive drowsiness when mixed with alcohol. Avoid alcohol to stay safe!
Pregnancy
CONSULT YOUR DOCTOR
Prostanil MR is generally safe during pregnancy. Animal studies show no harm to the baby, but human data is limited. Always consult your doctor before use.
Breastfeeding
CONSULT YOUR DOCTOR
Prostanil MR may pass into breast milk and harm your baby. Limited data suggests it’s likely unsafe during breastfeeding. Talk to your doctor about safer alternatives.
Driving
CAUTION
Prostanil MR usually doesn’t affect your ability to drive. However, if you experience dizziness or blurry vision, avoid driving until you feel better.
Kidney
CONSULT YOUR DOCTOR
Prostanil MR is safe for patients with kidney disease, and no dose adjustment is needed. However, consult your doctor if you have end-stage kidney disease.
Liver
CONSULT YOUR DOCTOR
Prostanil MR should be used cautiously in severe liver disease. Dose adjustments may be required. Always consult your doctor for guidance.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Key Benefits of Prostanil MR
- Relieves BPH symptoms like frequent or urgent urination.
- Helps empty the bladder.
✔️ Common Side Effects
- Retrograde ejaculation
- Dizziness
- Nasal congestion (stuffy nose)
If side effects persist, consult your doctor immediately.
✔️ Pharmacokinetics
- Absorption: 90% bioavailability when taken orally on an empty stomach.
- Peak Concentration (Tmax):
- 4-5 hours (fasting)
- 6-7 hours (with food)
- Protein Binding: 94-99% bound to plasma proteins.
- Metabolism: Extensively metabolized in the liver (CYP450 enzymes), with <10% excreted unchanged in urine.
- Half-life:
- Immediate-release form: 5-7 hours
- Modified-release (Prostam capsules):
- 9-13 hours (healthy individuals)
- 14-15 hours (BPH patients)
✔️ Dosage & Administration
- Initial dose: Tamsulosin 0.4 mg (one capsule) daily, taken after a meal at night.
- If necessary, increase to 0.8 mg (two capsules) once daily after 2-4 weeks.
- If therapy is interrupted for several days, restart with 0.4 mg once daily.
- The capsule must be swallowed whole with 150 ml water in a standing or sitting position.
- Do not crush or chew to maintain modified release.
⚠ Always follow your doctor’s prescription.
✔️ Quick Tips for Prostanil MR Users
- Take with food for better absorption.
- Avoid driving if you feel dizzy or sleepy.
- Inform your eye doctor before cataract or glaucoma surgery.
- Stay hydrated and avoid caffeine/alcohol before bedtime.
✔️ Drug Interactions
- Other alpha-1 blockers: May cause excessive hypotension.
- No interactions were observed with atenolol, enalapril, or nifedipine.
- Cimetidine: Increases Tamsulosin levels (but no dosage adjustment needed).
- Frusemide: Decreases plasma levels (no dosage adjustment needed).
- Diclofenac & Warfarin: May increase elimination of Tamsulosin.
- No significant hepatic metabolism interactions with amitriptyline, salbutamol, glibenclamide, or finasteride.
✔️ Tamsulosin should not be used in patients with:
- Hypersensitivity to Tamsulosin.
- History of orthostatic hypotension.
- Severe hepatic insufficiency.
✔️ Pregnancy & Lactation
- Not recommended for use in pregnant or lactating women.
✔️ Precautions & Warnings
- Risk of hypotension: May cause a drop in blood pressure, leading to dizziness, weakness, or syncope. Patients should sit or lie down if symptoms occur.
- Driving & Machinery: Patients should avoid hazardous activities (e.g., driving, operating machinery) due to the risk of dizziness.
- Pre-treatment Examination: Other conditions mimicking BPH should be ruled out before starting treatment. A digital rectal exam and Prostate-Specific Antigen (PSA) test should be performed before and during therapy.
- Use in micturition syncope: Not advised due to the risk of fainting.
✔️ Overdose Effects
- Acute overdose may lead to severe hypotension.
- Treatment:
- Lie the patient down to restore blood pressure.
- If needed, use volume expanders or vasopressors.
- Monitor renal function and provide supportive care.
- Dialysis is unlikely to be effective due to high protein binding.
- Large overdoses may require gastric lavage, activated charcoal, or osmotic laxatives.
✔️ Storage Condition
Store below 30°C in a cool, dry place, protected from light.
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ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
