Salmeterol Xinafoate: Selective long-acting β2-adrenoceptor agonist (12-hour effect). Relaxes airway muscles and prevents asthma/COPD symptoms.
Fluticasone Propionate: Inhaled corticosteroid with potent anti-inflammatory effect in the lungs, reducing symptoms and exacerbations without systemic side effects at recommended doses.
Combination effect: Salmeterol prevents symptoms, while Fluticasone improves lung function and prevents flare-ups.
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Asthma: For patients not adequately controlled with inhaled corticosteroids plus “as-needed” short-acting β2-agonist, or those already controlled on both inhaled corticosteroid and long-acting β2-agonist.
Chronic Obstructive Pulmonary Disease (COPD): To improve lung function and reduce exacerbations.
Use only under a registered doctor’s advice.
Asthma – Adults & Adolescents:
50 µg Salmeterol + 100/250 µg Fluticasone twice daily
Maximum: 50 µg + 500 µg twice daily
Children (4–11 years):
50 µg Salmeterol + 100 µg Fluticasone twice daily
COPD – Adults:
50 µg Salmeterol + 250 µg Fluticasone twice daily
Special Groups:
No dose adjustment needed for elderly or patients with renal impairment
Insufficient data for hepatic impairment
Avoid β-blockers unless necessary
Strong CYP3A4 inhibitors (ketoconazole, ritonavir) may increase fluticasone exposure
Use only if maternal benefit outweighs fetal/infant risk
Low systemic absorption; likely low exposure in breast milk
Salmeterol:
Tremor, headache, palpitations, arrhythmias (rare), muscle cramps, oropharyngeal irritation
Fluticasone Propionate:
Hoarseness, oral thrush, facial/oropharyngeal edema, hypersensitivity reactions
Gargling with water after use can reduce throat irritation and thrush.
Pressurised canister: do not puncture, break, or incinerate
Store below 30°C, away from sunlight, heat, eyes, and children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.