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Duotide Unicap 25mcg+62.5mcg
Duotide (Vilanterol Trifenatate+Umeclidinium Bromide) is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).
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Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Each Dry Powder Inhaler capsule contains:
- Vilanterol 25 micrograms (as Vilanterol Trifenatate INN)
- Umeclidinium 62.5 micrograms (as Umeclidinium Bromide INN)
Duotide is an inhalation powder containing a combination of Umeclidinium, an anticholinergic agent, and Vilanterol, a long-acting beta₂-agonist (LABA), administered via inhalation.
The pharmacological effects of beta₂-adrenergic agonists such as vilanterol are attributed to stimulation of intracellular adenyl cyclase, an enzyme that converts adenosine triphosphate (ATP) into cyclic 3’,5’-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle and inhibit the release of mediators of immediate hypersensitivity, particularly from mast cells.
Umeclidinium is a long-acting muscarinic antagonist (LAMA), commonly referred to as an anticholinergic. It exhibits similar activity across muscarinic receptor subtypes M₁ to M₅. It works by blocking M₃ receptors in airway smooth muscle, resulting in bronchodilation.
✔️ Dosage of Duotide
Adult Dose (18 years and above)
Should be taken at the same time each day and not more than once every 24 hours.
Recommended Dose for COPD Maintenance Therapy
One inhalation of 25/62.5 micrograms once daily
Limitations of Use
Not indicated for the relief of acute bronchospasm
Not indicated for the treatment of asthma
Use in Children and Adolescents
Not recommended for use in children and adolescents
Safety and efficacy have not been established in patients aged 17 years or younger
Geriatric, Renal, or Moderate Hepatic Impairment
No dose adjustment is required
✔️ Administration of Duotide
The inhalation capsules must not be swallowed.
Capsules should be used only with the inhaler device.
Remove the capsule from the blister pack immediately before use.
After each use, rinse the mouth with water to reduce the risk of oropharyngeal candidiasis.
✔️ Side Effect
- Pharyngitis
- Sinusitis
- Lower respiratory tract infection
- Constipation
- Diarrhea
- Pain in extremities
- Muscle spasms
- Neck pain
- Chest pain
✔️ Drug Interaction
- Strong CYP3A4 inhibitors (e.g., ketoconazole): Use with caution due to potential systemic corticosteroid and cardiovascular effects
- Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants: Use with extreme caution as vilanterol’s vascular effects may be enhanced
- Beta-blockers: May block bronchodilatory effects and cause bronchospasm
- Diuretics: May increase the risk of ECG changes and/or hypokalemia, particularly with non–potassium-sparing diuretics
- Anticholinergics: Concurrent use may increase anticholinergic effects; avoid use with other anticholinergic-containing drugs
✔️ Contraindications:
- Hypersensitivity to milk proteins or any component of the formulation
- Use of LABA-containing products without inhaled corticosteroids is contraindicated in patients with asthma
✔️ Pregnancy & Lactation
There are insufficient data regarding the use of Duotide in pregnant women and breastfeeding mothers. Use only if clearly needed and under medical supervision.
✔️ Precautions & Warnings
- LABA monotherapy increases the risk of serious asthma-related events
- Do not initiate treatment during acute deterioration of COPD or asthma
- Not intended for relief of acute symptoms
- Do not use with additional LABA-containing therapies due to overdose risk
- Discontinue immediately if paradoxical bronchospasm occurs
- Use cautiously in patients with cardiovascular disorders due to beta-adrenergic stimulation
- Use with caution in patients with seizure disorders, thyrotoxicosis, diabetes mellitus, or ketoacidosis
- May worsen narrow-angle glaucoma; patients should seek immediate medical attention if symptoms occur
- May cause urinary retention; use cautiously in patients with prostatic hyperplasia or bladder-neck obstruction
- Monitor for hypokalemia and hyperglycemia
✔️ Storage:
Store in a cool, dry place away from direct sunlight and heat.
Keep out of reach of children.
Avoid contact with eyes.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
