Eposis 5000 Injection - ePharma
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Eposis 5000 IU Injection

Type: Injection

Pack Size: 1s pack

Generic Name: Erythropoietin 5000IU

Manufacturer/Distributor: Beacon Pharmaceuticals Ltd. 


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Discount Price: ৳ 2015.31
MRP: ৳ 2167 7% Off

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Description:

Indications of Eposis 5000 IU

Erythropoietin is used to treat anemia associated with chronic renal failure in both dialysis and non-dialysis patients.

Anemia in patients with non-myeloid malignancies who are experiencing anemia as a result of concurrent treatment.

To decrease the need for allogeneic blood transfusions, anemic patients (hemoglobin >10 to 13 g/dL) are scheduled for elective, noncardiac, and nonvascular surgery. In HIV-positive patients, anemia is linked to zidovudine medication.

Dosage and Administration of Eposis 5000 IU

Treatment of anemia in chronic renal failure: Erythropoietin is administered to maintain hemoglobin concentration between 11 to 12 g/dl and hematocrit of 33-36 % in adults.

Starting dose:

Adult: Usually 50 to 100 lU/kg three times in a week (TIW) by IV or Subcutaneous route.

Pediatric: 50 lU/kg TIW by IV or Subcutaneous route.

Dose adjustment: The dose should be increased if hematocrit does not increase by 5 to 6 points after 8 weeks of therapy, and hematocrit is below the suggested target range. The dose should be reduced when hematocrit approaches 36% or hematocrit increases >4 points in any 2-week period.

Maintenance dose: Maintenance dose must be individualized for each patient. In patients undergoing dialysis, the median maintenance dose is 75 lU/kg TIW, with a range from 12.5 to 525 lU/kg TIW as directed by the physician. In CRF patients not on dialysis, the maintenance dose is 75 to 150 lU/kg/week.

Treatment of Anemia in Cancer Patients on Chemotherapy:

Starting dose:

Adult: 150 lU/kg TIW by Subcutaneous route or 40,000 IU Subcutaneous route weekly.

Pediatric: 25 to 300 lb/kg 3 to 7 times per week by Subcutaneous or IV route.

Dose adjustment: If the response is not satisfactory, the dose should be increased to 300 lU/kg TIW. If the hematocrit exceeds 40%, the dose should be withheld until the hematocrit falls to 36%. The dose should be reduced to 25% when treatment is resumed and titrated to maintain the desired hematocrit.

Surgery Patients: The recommended dose is 300 lU/kg/day subcutaneously for 10 days before surgery, on the day of surgery, and for 4 days after surgery. An alternate dose schedule is 600 lU/kg subcutaneously in a once-weekly doses (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery.

Zidovudine-treated HIV-infected Patients:
Starting dose

Adult: 100 lU/kg as an IV or Subcutaneous injection TIW for 8 weeks.

Pediatric: 50 to 400 lU/kg 2 to 3 times per week by Subcutaneous or IV route.

Dose adjustment: If the response is not satisfactory, the dose should be increased by 50-1001U/kg TIW. Response should be evaluated every 4 to 8 weeks thereafter and the dose adjusted accordingly by 50 to 100 lU/kg increments TIW.

Maintenance dose: The dose is titrated to maintain the hematocrit between 33-36%.

 

Contraindications

In patients with uncontrolled hypertension, erythropoietin is contraindicated.

Hypersensitivity to mammalian cell-derived products is well-known.

Hypersensitivity to Erythropoietin or any of the preparation's components.

Side Effects of Eposis 5000 IU

Headache, dizziness, fever, malaise, arthralgia, and hyperkalemia are common symptoms. Cardiovascular: The most prevalent side effect is hypertension, followed by palpitations. Nausea, vomiting, anorexia, and diarrhea are common gastrointestinal symptoms. Allergic responses are common.

Pregnancy & Lactation

Pregnancy Classification C. Because there are no controlled trials of erythropoietin in pregnant women and animal reproduction studies are not necessarily predictive of human responses, erythropoietin should only be taken if plainly needed during pregnancy. This medication is not known to be excreted in human milk. Because many medicines are excreted in human milk, erythropoietin should be given with caution to a nursing mother.

Precautions & Warnings

In individuals with controlled hypertension, ischemic vascular disease, a history of seizures, or a suspected allergy to the substance, erythropoietin should be administered with caution.

Iron evaluation: The patient's iron storage, particularly transferrin saturation, and serum ferritin, should be assessed before and during Erythropoietin therapy. The saturation of transferrin should be at least 20%, and the ferritin level should be at least 100 ng/ml. To increase or maintain transferrin saturation levels that will sufficiently support erythropoiesis, almost all patients will require supplementary Iron.

Storage Conditions

Erythropoietin should be stored between 2 and 8 degrees Celsius. Protect yourself from the sun. Avoid freezing and shaking.

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Check our pricing section for Eposis 5000 IU Injection price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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