Glyset Vita Vial

✔️ Dosage

Insulin Aspart has a rapid onset and short duration of action, and is typically administered immediately before meals. If required, it may be given shortly after a meal.

Dosage is individualized based on the patient’s metabolic needs, blood glucose monitoring, and physician guidance. It is commonly used in combination with a long-acting basal insulin, administered at least once daily.

Total daily insulin requirement: Generally ranges from 0.5–1.0 IU/kg/day in adults and children over 2 years

Meal-related therapy: Approximately 50–70% of the total daily dose may be provided by Insulin Aspart, with the remainder supplied by long-acting insulin

Dose adjustments may be required during changes in physical activity or dietary habits. Exercise immediately after meals may increase the risk of hypoglycemia.

✔️ Side Effects

• Hypoglycemia
• Allergic reactions
• Injection site reactions
• Lipodystrophy
• Pruritus and skin rash

✔️ Route of Administration

Subcutaneous Injection

Administer by subcutaneous injection into the abdomen, thigh, buttocks, or upper arm. Due to its rapid onset, Insulin Aspart should be injected within 5–10 minutes before a meal.

Continuous Subcutaneous Insulin Infusion (CSII)

Insulin Aspart may be delivered via an external insulin pump. Initial pump settings should be based on the patient’s previous total daily insulin dose. Typically, around 50% is administered as meal-related boluses and the remainder as basal infusion. Insulin Aspart should not be mixed with other insulins when used in pumps.

Intravenous Administration

Intravenous use is permitted under strict medical supervision with close monitoring of blood glucose and potassium levels. Recommended concentrations range from 0.05 to 1.0 IU/mL in infusion solutions such as 0.9% sodium chloride, using polypropylene infusion bags.

✔️ Administration Instructions (for Patients)

Insert the cartridge properly into the ConviPen and attach a new needle

Gently invert the pen 8–10 times to ensure uniform mixing

Remove the needle cap and expel air bubbles

Set the prescribed dose and inject into the recommended site

Avoid contact of the needle with any surface to prevent contamination

✔️ Drug Interactions

Several medications can influence glucose metabolism and may necessitate insulin dose adjustment.

Agents that may reduce insulin requirements:
Oral antidiabetics, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, propoxyphene, pentoxifylline, salicylates, sulfonamide antibiotics.

Agents that may increase insulin requirements:
Thiazide diuretics, glucocorticoids, thyroid hormones, beta-agonists, growth hormone, danazol.

Beta-blockers, clonidine, lithium, and alcohol may either enhance or reduce insulin’s glucose-lowering effect.

✔️ Pregnancy & Lactation

Pregnancy Category B: Insulin Aspart can be used during pregnancy when clinically indicated.

Lactation: Insulin therapy in breastfeeding mothers does not adversely affect the infant; however, dose adjustments may be necessary.

✔️ Precautions & Warnings

Blood glucose levels should be regularly monitored

Dose changes must be made cautiously and under medical supervision

Increased vigilance is required during changes in diet, activity, or concurrent illness

✔️ Storage:

Store at 2°C–8°C in a refrigerator. Do not freeze. Protect from light.