Generic: Insulin Aspart
Type: Injection
Pack Size: 1 Pc
Protamine Crystallized Insulin Aspart, also known as protamine insulin aspart or insulin aspart protamine suspension (NPH insulin), is an insulin analog used to improve glycemic control in patients with diabetes mellitus.
Insulin analogs are modified forms of insulin that are designed to mimic the natural release and action of insulin in the body. Protamine Crystallized Insulin Aspart combines rapid-acting insulin aspart with protamine, a protein that helps to slow down the absorption and prolong the duration of insulin action. This formulation provides both a rapid-acting and intermediate-acting effect, helping to control blood glucose levels over an extended period of time.
Patients with diabetes mellitus may be prescribed Protamine Crystallized Insulin Aspart regulate their blood sugar levels. It is important to follow the prescribed dosage and administration instructions provided by your healthcare provider. Regular monitoring of blood glucose levels and close communication with your healthcare team are essential for optimal glycemic control.
As with any medication, there may be potential side effects or interactions to consider. It is important to consult with your healthcare provider to discuss any specific concerns or questions you may have about the use of Protamine Crystallized Insulin Aspart for your diabetes management. They can provide personalized guidance and adjust your treatment plan accordingly.
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NovoRapid Penfill Cartridge is a medication containing Insulin Aspart and is classified as an Antidiabetic agent. It is used to treat both type 1 and type 2 diabetes mellitus.
Diabetes mellitus is a chronic condition characterized by elevated blood glucose levels. It occurs either due to insufficient production of the hormone insulin by the pancreas or due to decreased sensitivity of body cells to insulin.
NovoRapid Penfill is a rapid-acting insulin that starts to lower blood sugar levels within 10-20 minutes after administration. Its effects can last for approximately 3-4 hours. This medication is suitable for use in adults and children aged 1 year and older.
Prior to starting treatment with NovoRapid Penfill Cartridge, it is important to discuss your medical history, including any liver, kidney, or heart problems, with your doctor. Inform your doctor if you have any hormonal issues, have recently made significant changes to your diet, or engage in intense exercise as a precautionary measure.
Avoid using this medication if you have hypoglycemia (low blood sugar levels). If you are pregnant or breastfeeding, consult your doctor before using NovoRapid Penfill Cartridge.
The most common side effects associated with injecting NovoRapid Penfill Cartridge include low blood sugar levels, pain, redness, itching, swelling, or thickening at the injection site, the formation of lumps under the skin, and swelling of body parts. If you experience any of these side effects and they trouble you, consult your doctor for further guidance.
Administration
SC injection Should be taken with food. Administer immediately within 5-10 minutes before a meal. When administered by SC injection, insulin aspart should generally be used in regimens with intermediate- or long-acting insulin Administer subcutaneously in the upper arm, thigh or abdominal wall. Subcutaneous injection into the abdominal wall results in faster absorption than from other injection sites. Injection sites should be rotated within the same region to reduce the risk of lipodystrophy
Adult Dose
Subcutaneous Type 1 Diabetes Mellitus Improvement of glycemic control in adults and children with diabetes mellitus May administer 0.2-0.6 unit/kg/day in divided doses; conservative doses of 0.2-0.4 unit/kg/day often recommended to reduce risk of hypoglycemia Total maintenance daily insulin requirement may vary; it is usually between 0.5 and 1 unit/kg/day; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.6-1.2 units/kg/day Type 2 Diabetes Mellitus Diabetes inadequately controlled by diet, weight reduction, exercise, or oral medication Initial: 0.2-0.4 units/kg/day SC divided q8hr-q12hr. And an intermediate (eg, NPH) or long-acting insulin at bedtime recommended; Hepatic impairment: Dosage reduction may be needed. Dosing Considerations When used in a meal-related SC injection treatment regimen, 50-75% of total insulin requirements may be provided by an intermediate-acting or long-acting insulin; the remainder is divided and provided before or at mealtimes as a rapid-acting insulin, such as insulin aspart Dosage must be individualized; blood and urine glucose monitoring is essential in all patients receiving insulin therapy
Child Dose
Subcutaneous Type 1 Diabetes Mellitus Improvement of glycemic control in adults and children with diabetes mellitus >2 years: May require 0.8-1.2 units/kg/day SC during growth spurts; adolescents may require <1.2 units/kg/day; otherwise, may use 0.5-1 unit/kg/day
Renal Dose
Renal impairment: Dose adjustments may be needed.
Contraindication
Hypoglycaemia. Hypersensitivity to any of the components.
Mode of Action
Insulin aspart, a rapid-acting analog of human insulin, lowers blood glucose levels; it regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Precaution
Pregnancy (insulin requirements tend to fall during the 1st trimester, increase during the 2nd and 3rd) and lactation. Caution with decreased insulin requirements: Diarrhea, nausea/vomiting, malabsorption, hypothyroidism, renal impairment, hepatic impairment Hypokalemia may occur Use with caution in renal and hepatic impairment (dosage requirements may be reduced) Caution with increased insulin requirements: Fever, hyperthyroidism, trauma, infection, surgery Lactation: Safe to use while breastfeeding
Side Effect
Allergic reactions. Injection site reaction, lipodystrophy, pruritus, rash, lipoatrophy, hypokalaemia, blurred vision. Hypoglycaemia, insulin resistance.
Interaction
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, and lithium. Signs of hypoglycemia may be masked by beta-blockers, clonidine.
Alcohol is not safe for consumption when taking this medication as it increases the risk of both hypo and hyperglycemia. Consuming alcohol while taking this medication can lead to severe side effects such as dizziness, drowsiness, and more.
This medicine is considered safe for use on pregnant women; however, this medicine should be started only after a doctor's consultation.
is considered safe for use during breastfeeding. However, consult your doctor before administration.
Low blood sugar can affect your ability to drive. If your blood sugar is low, it can affect your concentration ability. Consult your doctor about whether you can drive if you often get low blood sugar.
NovoRapid Penfill Cartridge should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.
NovoRapid Penfill Cartridge should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.
NovoRapid Penfill Cartridge aids in your body's use of the blood glucose that is present. It aids in the movement of glucose from the blood into the tissues of the muscles and fat. Additionally, it halts the liver's generation of glucose. As a result, it regulates blood sugar levels and helps people with diabetes mellitus better manage their blood sugar.
NovoRapid Penfill Cartridge is used for blood sugar control in people with type 1 and type 2 diabetes mellitus. It is a fast-acting type of insulin that helps to lower blood sugar levels after meals and reduces the chances of developing serious complications of diabetes.
Insulin Aspart regulates glucose metabolism as its principal function. By increasing the uptake of glucose by cells and decreasing the liver's production of it, Insulin Aspart lowers blood glucose.
Dosage recommendations for insulin administration in different populations are as follows:
Adult Dose:
Type 1 Diabetes Mellitus:
Type 2 Diabetes Mellitus:
Dosing Considerations:
Child Dose:
Renal Dose:
Dose adjustments may be necessary for individuals with renal impairment.
Administration:
If you are allergic to this medicine or any of the ingredients of this medicine.
It's a category B pregnancy. Protamine Crystallized Insulin Aspart can be used during lactation without any restrictions. A breastfeeding mother's insulin therapy should have no effect on the baby's health. In some cases, the dosage may have to be changed.
It is important for all patients receiving insulin to have their blood glucose levels regularly monitored. This allows for the proper management of diabetes and helps ensure that insulin doses are appropriate for individual needs.
Any changes in insulin regimens, including adjustments in dosage or timing, should always be done under the supervision of a physician. This is because altering insulin regimens without medical guidance can be risky and may lead to complications or imbalances in blood glucose levels.
Physicians have the expertise to assess a patient's specific condition, consider factors such as overall health, lifestyle, and other medications, and make informed decisions regarding insulin dose adjustments. Therefore, it is crucial to involve a healthcare professional in any modifications to insulin regimens to ensure patient safety and optimal diabetes management.
Store in a refrigerator (2 - 8°C). Do not freeze.
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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only.
The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.