Protamine Crystallized Insulin Aspart, also known as protamine insulin aspart or insulin aspart protamine suspension (NPH insulin), is an insulin analog used to improve glycemic control in patients with diabetes mellitus.
Insulin analogs are modified forms of insulin that are designed to mimic the natural release and action of insulin in the body. Protamine Crystallized Insulin Aspart combines rapid-acting insulin aspart with protamine, a protein that helps to slow down the absorption and prolong the duration of insulin action. This formulation provides both a rapid-acting and intermediate-acting effect, helping to control blood glucose levels over an extended period of time.
Patients with diabetes mellitus may be prescribed Protamine Crystallized Insulin Aspart regulate their blood sugar levels. It is important to follow the prescribed dosage and administration instructions provided by your healthcare provider. Regular monitoring of blood glucose levels and close communication with your healthcare team are essential for optimal glycemic control.
As with any medication, there may be potential side effects or interactions to consider. It is important to consult with your healthcare provider to discuss any specific concerns or questions you may have about the use of Protamine Crystallized Insulin Aspart for your diabetes management. They can provide personalized guidance and adjust your treatment plan accordingly.
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NovoRapid Penfill Cartridge is a medication containing Insulin Aspart and is classified as an Antidiabetic agent. It is used to treat both type 1 and type 2 diabetes mellitus.
Diabetes mellitus is a chronic condition characterized by elevated blood glucose levels. It occurs either due to insufficient production of the hormone insulin by the pancreas or due to decreased sensitivity of body cells to insulin.
NovoRapid Penfill is a rapid-acting insulin that starts to lower blood sugar levels within 10-20 minutes after administration. Its effects can last for approximately 3-4 hours. This medication is suitable for use in adults and children aged 1 year and older.
Prior to starting treatment with NovoRapid Penfill Cartridge, it is important to discuss your medical history, including any liver, kidney, or heart problems, with your doctor. Inform your doctor if you have any hormonal issues, have recently made significant changes to your diet, or engage in intense exercise as a precautionary measure.
Avoid using this medication if you have hypoglycemia (low blood sugar levels). If you are pregnant or breastfeeding, consult your doctor before using NovoRapid Penfill Cartridge.
The most common side effects associated with injecting NovoRapid Penfill Cartridge include low blood sugar levels, pain, redness, itching, swelling, or thickening at the injection site, the formation of lumps under the skin, and swelling of body parts. If you experience any of these side effects and they trouble you, consult your doctor for further guidance.
Alcohol is not safe for consumption when taking this medication as it increases the risk of both hypo and hyperglycemia. Consuming alcohol while taking this medication can lead to severe side effects such as dizziness, drowsiness, and more.
CONSULT YOUR DOCTOR
This medicine is considered safe for use on pregnant women; however, this medicine should be started only after a doctor's consultation.
CONSULT YOUR DOCTOR
is considered safe for use during breastfeeding. However, consult your doctor before administration.
Low blood sugar can affect your ability to drive. If your blood sugar is low, it can affect your concentration ability. Consult your doctor about whether you can drive if you often get low blood sugar.
NovoRapid Penfill Cartridge should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.
NovoRapid Penfill Cartridge should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.
Treats Diabetes Mellitus (both type I and type II)
How does NovoRapid Penfill Cartridge work?
NovoRapid Penfill Cartridge aids in your body's use of the blood glucose that is present. It aids in the movement of glucose from the blood into the tissues of the muscles and fat. Additionally, it halts the liver's generation of glucose. As a result, it regulates blood sugar levels and helps people with diabetes mellitus better manage their blood sugar.
Side Effects of NovoRapid Penfill Cartridge
Hypokalaemia (low potassium)
Hypoglycaemia (low blood sugar level)
Local injection site reactions
Lipodystrophy (fat deposition under the skin)
Nasopharyngitis (inflammation of the throat and nasal passages)
Upper respiratory tract infection
Pruritus (itchy skin)
Take it 15 minutes before a meal or within 20 minutes after starting a meal.
Engaging in physical exercise can reduce the body's insulin requirements both during and sometimes after the activity. Additionally, exercise can accelerate the effects of an insulin dose, particularly if the exercise involves the same area where the insulin injection was administered (for instance, it is advisable not to inject insulin into the leg just before running).
It is important to have a discussion with your doctor about how to adjust your insulin regimen to accommodate exercise. They can provide guidance on the appropriate timing, dosage, and potential adjustments to your insulin routine to ensure optimal glycemic control during physical activity.
In terms of diet, it is recommended to avoid consuming sugary foods and instead opt for low-calorie, cooked meals. This can help in managing blood sugar levels and overall calorie intake.
When traveling across multiple time zones, it is advisable to consult with your doctor regarding adjustments to your insulin schedule. Time zone changes can affect the timing of your medication, and your healthcare provider can provide guidance on how to adapt your insulin regimen to the new schedule.
Hypoglycemia (low blood sugar level) is a common side effect. Monitor your blood sugar level regularly.
Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremors, weakness, and anxiety.
Injection below the skin of the abdomen results in faster absorption than other injection sites.
Injection sites must be rotated to prevent hard lumps from developing at one site.
Opened vials/cartridges stay good at room temperature for up to 4 weeks, while unopened vials must be placed in the refrigerator (2°C–8°C).
Do not use it if the preparation is no longer clear and colorless or if it contains particles.
Indication of NovoRapid Penfill Cartridge
NovoRapid Penfill Cartridge is used for blood sugar control in people with type 1 and type 2 diabetes mellitus. It is a fast-acting type of insulin that helps to lower blood sugar levels after meals and reduces the chances of developing serious complications of diabetes.
Insulin Aspart regulates glucose metabolism as its principal function. By increasing the uptake of glucose by cells and decreasing the liver's production of it, Insulin Aspart lowers blood glucose.
Dosage & Administration of NovoRapid Penfill Cartridge
Dosage recommendations for insulin administration in different populations are as follows:
Type 1 Diabetes Mellitus:
To improve glycemic control in adults and children with diabetes mellitus, the recommended dose is usually 0.2-0.6 unit/kg/day, divided into multiple doses. However, conservative doses of 0.2-0.4 units/kg/day are often advised to minimize the risk of hypoglycemia. The total daily maintenance insulin requirement may vary between 0.5 and 1 unit/kg/day. Non-obese individuals may require 0.4-0.6 unit/kg/day, while obese individuals may require 0.6-1.2 units/kg/day.
Type 2 Diabetes Mellitus:
For diabetes inadequately controlled by diet, weight reduction, exercise, or oral medication, the initial recommended dose is 0.2-0.4 units/kg/day, administered subcutaneously in divided doses every 8-12 hours. It is often recommended to add intermediate-acting or long-acting insulin at bedtime. In cases of hepatic impairment, dosage reduction may be necessary.
When using a meal-related subcutaneous injection treatment regimen, approximately 50-75% of the total insulin requirements can be provided by intermediate-acting or long-acting insulin, with the remainder divided and administered before or during mealtimes as rapid-acting insulin, such as insulin aspart. Dosage must be tailored to the individual, and regular monitoring of blood and urine glucose levels is essential for all patients receiving insulin therapy.
Type 1 Diabetes Mellitus: In children with diabetes mellitus aged 2 years and older, the recommended dose may range from 0.8-1.2 units/kg/day subcutaneously during growth spurts. Adolescents may require less than 1.2 units/kg/day. For other situations, a dose of 0.5-1 unit/kg/day may be used.
Dose adjustments may be necessary for individuals with renal impairment.
It is important to note that these are general dosage guidelines, and individualized treatment plans should be determined in consultation with a healthcare professional. Regular monitoring of blood glucose levels is essential for effective management of diabetes.
When administering this medication, always inject it subcutaneously into your thighs, buttocks, upper arm, or abdomen. Avoid injecting it directly into a vein or muscle. It is recommended to administer the injection at least 10 minutes before meals. To prevent low blood sugar, consume a meal or snack containing carbohydrates within 20 minutes of the injection.
Before use, gently roll the vial or cartridge between your hands until the liquid appears uniformly white and cloudy. During the injection, ensure that the needle remains under the skin for at least 6 seconds to ensure the complete dose is delivered.
Before administration, visually inspect the vial or cartridge for any visible particles or discoloration. Dispose of the needle and syringe after use and do not share them with others to prevent the risk of infection transmission.
To prevent skin damage, avoid injecting the medication repeatedly at the same site. Instead, rotate the injection site as recommended by your doctor. It is important to consult your doctor before changing the injection site as a precautionary measure.
NovoRapid Penfill Cartridge may interact with several drugs, including disopyramide (antiarrhythmic), pentoxifylline (hemorheological agent), pramlintide (antidiabetic), octreotide (bleeding disorder drug), propoxyphene and phenothiazines (antipsychotics), progestogens and estrogens (female sex hormones), levothyroxine (thyroid hormone), albuterol, epinephrine, and terbutaline (anti-asthmatics), fluoxetine and lithium (antidepressants), reserpine, niacin, clonidine, fenofibrate, and guanethidine (lipid-lowering pills), aspirin (painkiller), isoniazid (antibiotic), glucagon (blood sugar enhancing pills), and danazol (male hormone testosterone analog). Additionally, it may interact with the antibiotic pentamidine.
NovoRapid Penfill Cartridge may also interact with ayurvedic, homeopathy, Unani, herbal supplements, or over-the-counter (OTC) items. It is important to inform your doctor if you are using any of these products. It is advisable to avoid consuming alcoholic beverages while takingNovoRapid Penfill Cartridge, as it may affect your blood sugar levels.
There are certain disease conditions where NovoRapid Penfill Cartridge should not be used. These include kidney disease, liver disease, low blood sugar/glucose levels (hypoglycemia), and low potassium levels (hypokalemia). It is important to discuss your medical history and any existing conditions with your doctor before using this medication.
If you are allergic to this medicine or any of the ingredients of this medicine.
Pregnancy & Lactation
It's a category B pregnancy. Protamine Crystallized Insulin Aspart can be used during lactation without any restrictions. A breastfeeding mother's insulin therapy should have no effect on the baby's health. In some cases, the dosage may have to be changed.
Precautions & Warnings
It is important for all patients receiving insulin to have their blood glucose levels regularly monitored. This allows for the proper management of diabetes and helps ensure that insulin doses are appropriate for individual needs.
Any changes in insulin regimens, including adjustments in dosage or timing, should always be done under the supervision of a physician. This is because altering insulin regimens without medical guidance can be risky and may lead to complications or imbalances in blood glucose levels.
Physicians have the expertise to assess a patient's specific condition, consider factors such as overall health, lifestyle, and other medications, and make informed decisions regarding insulin dose adjustments. Therefore, it is crucial to involve a healthcare professional in any modifications to insulin regimens to ensure patient safety and optimal diabetes management.
Developed by humans, Novorapid Penfill is a fast-acting substitute for human insulin. Recombinant DNA technology, a biotechnological procedure, is used to create it. Using the fungus Saccharomyces cerevisiae, the DNA is purposely changed in this method to get the desired result. It is marketed as a sterile, aqueous, colorless solution that also contains additional ingredients including glycerin, phenol, metacresol, zinc, sodium chloride, and insulin aspart.
Depending on the patient's needs, a Novorapid Penfill dosage is recommended. Regularly take Novorapid Penfill and follow your doctor's instructions to the letter. It is typically administered together with long-acting or intermediate-acting insulin. You should have a meal or snack within 10 minutes after the insulin injection to prevent low blood sugar. It is given subcutaneously (under the skin) five to ten minutes before a meal. It can also be administered just after eating.
Type 1 and type 2 diabetes mellitus can both be treated with Novorapid 100Iu/ml Penfill 5 x 3 ml. Nevertheless, based on your current health, your doctor will determine whether or not Novorapid 100Iu/ ml Penfill 5 × 3 ml can be administered to you. Patients with allergies to Novorapid 100Iu/ ml Penfill 5 x 3 ml or other types of insulin, kidney or liver illness, low blood sugar or glucose levels (hypoglycaemia), or low potassium levels (hypokalaemia) should not use Novorapid 100Iu/ ml Penfill 5 x 3 ml.
No. You should not stop therapy with NovoRapid Penfill Cartridge without consulting your doctor because it may lead to the reversal of symptoms. If you feel better after using NOVORAPID PENFILL CARTRIDGE, consult your doctor for advice.
It is not advisable to take medicines to control blood pressure while taking NOVORAPID PENFILL CARTRIDGE without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with NOVORAPID PENFILL CARTRIDGE as they have known interactions with NOVORAPID PENFILL CARTRIDGE.
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