Ansulin 30/70 Vial 40IU/ml

✔️ Uses of Ansulin 30/70 Vial 40IU

• Treats Diabetes Mellitus (both type I and type II)

✔️ How does Ansulin 30/70 Vial 40IU work?

Insulin is crucial for glucose to enter cells as fuel. In type 1 diabetes, inadequate insulin causes high blood glucose. This medicine lowers blood sugar by promoting glucose uptake in cells and tissues, mainly muscles and fat, while also reducing liver glucose production.

✔️ Side Effects of Ansulin 30/70 Vial 40IU

• Tingling of hands or feet
• Dry mouth
• Diarrhoea
• Headache
• Sneezing
• Fever
• Body pain
• Unusual weight gain or loss
• Nausea and vomiting
• Pain at the injection site
• Dizziness
• Drowsiness
• Confusion
• Changes in vision
• Chills
• Slurred speech
• Shortness of breath
• Anxiety
• Swelling in the arms or legs.
• Convulsions (fits)
• Loss of consciousness

✔️ Quick Suggestions:

• Include foods rich in healthy carbohydrates and fiber, such as fruits, whole grains, and vegetables. These foods have a slower impact on blood sugar levels.
• Eating at regular intervals and avoiding skipping meals helps stabilize blood sugar levels.
• Avoid overeating to prevent large spikes in blood sugar.
• Complement your treatment with Ansulin 30/70 Vial 40IU/ml by incorporating regular physical activity.
• Walking for a few minutes can be a great addition to your routine.
• Maintain a healthy weight through regular exercise and a balanced diet.
• Prioritize proper rest and consider stress-reduction techniques like meditation or yoga.
• Be attentive to symptoms of hypoglycemia (low blood sugar) like fatigue, dizziness, confusion, heart palpitations, shakiness, and anxiety.
• If you experience these symptoms, consult your doctor promptly.

✔️ Indication of Ansulin 30/70 Vial 40IU/ml

Ansulin 30/70 Vial 40IU/ml is used for the treatment of diabetes.

✔️ Pharmacology

Insulin's Role and Actions:

• Insulin plays a vital role in regulating carbohydrate, protein, and fat metabolism in the body.
• It lowers blood glucose levels by inhibiting hepatic (liver) glucose production and lipolysis (breakdown of fats), while enhancing peripheral (outside the liver) glucose disposal.

Insulin Formulations and Classification:

• Insulin formulations are categorized based on their durations of action following subcutaneous (SC) injection.
• They are grouped into short-acting, intermediate-acting, or long-acting insulin.

Soluble (Regular) Insulin:

• Soluble insulin, also known as 'neutral insulin' or 'regular insulin,' is a short-acting preparation.
• It is typically used to manage post-meal blood sugar spikes and requires multiple daily injections.

Extending Insulin's Duration of Action:

• Insulin preparations can be formulated as suspensions to prolong their effects.
• Two methods are used: complexing insulin with a protein for slow release (e.g., protamine zinc insulin and isophane insulin), or modifying particle size (e.g., insulin zinc suspensions).

Administration Routes:

• Most insulin formulations are administered via subcutaneous (SC) injection, while some can be given intramuscularly (IM) injection.
• Only soluble insulin can be administered intravenously (IV).
• IM administration typically has a faster onset of action and a shorter duration of action compared to SC injection.

✔️ Dosage & Administration of Ansulin 30/70 Vial 40IU/ml

Adult Dose:

• For Type 1 Diabetes Mellitus:
  • Suggested starting dose based on ketone levels: Moderate or fewer ketones: 0.5 U/kg/day SC, Large ketones: 0.7 U/kg/day SC.
  • Typically, 50-75% of the total daily dose is given as intermediate- or long-acting insulin.
• For Type 2 Diabetes Mellitus:
  • Suggested starting dose: 0.5-1 units/kg/day in divided doses (initial dosages for type 2 diabetic patients are often lower, e.g., 0.3 to 0.6 IU/kg/day).
  • Similar to type 1 diabetes, 50-75% of the total daily dose is given as intermediate- or long-acting insulin.
• Dosage adjustments must be based on blood and urine glucose test results, and changes should be made in small increments.
• Hepatic impairment might require dosage reduction.

Child Dose:

• Similar to adult guidelines, with suggested starting doses based on ketone levels for Type 1 Diabetes Mellitus.

Renal Dose:

• Renal impairment might require dose adjustments.

Administration Directions:

• Inject subcutaneously (into the thighs, buttocks, upper arm, or abdomen).
• Administer 30 minutes before meals.
• Eat a meal or snack containing carbohydrates within 30 minutes to prevent low blood sugar.
• Roll the vial/cartridge to mix the liquid before administration.
• Keep the needle under the skin for at least 6 seconds to ensure the full dose is injected.
• Visualize the vial/cartridge for particulate matter or discoloration before administration.
• Rotate injection sites to avoid skin damage.
• Do not mix Ansulin 30/70 Vial 40IU/ml with other insulins.
• Do not stop therapy without consulting a doctor.

✔️ Interaction

Medications and Substances That May Reduce Insulin Requirement:

• Oral hypoglycemic agents (medications for lowering blood sugar)
• Monoamine oxidase inhibitors (MAOIs, a class of antidepressants)
• Nonselective beta-blockers (used to treat various conditions)
• ACE inhibitors (angiotensin-converting enzyme inhibitors, used for hypertension and heart failure)
• Salicylates (aspirin and related compounds)
• Alcohol
• Anabolic steroids
• Sulphonamides (a class of antibiotics)

Medications and Substances That May Increase Insulin Requirement:

• Oral contraceptives (OCs)
• Thiazide diuretics (used for hypertension)
• Glucocorticoids (steroid hormones)
• Thyroid hormones
• Sympathomimetics (agents that mimic the effects of the sympathetic nervous system)
• Danazol (a synthetic steroid)
• Octreotide and lanreotide (somatostatin analogs)

Effects on Hypoglycemia:

• Beta-blockers may mask the symptoms of hypoglycemia, making it harder to detect low blood sugar.
• Alcohol consumption can intensify or reduce the hypoglycemic effect of insulin.

✔️ Contraindications

• If you are allergic to insulin or other ingredients of Ansulin 30/70 Vial 40IU/ml.
• If you have hypoglycemia (low blood sugar level).

✔️ Pregnancy & Lactation

Since insulin does not cross the placental barrier, there are no restrictions on the treatment of diabetes with pregnancy insulin. Insulin treatment in nursing mothers poses no risk to the baby.

✔️ Precautions & Warnings

Pregnancy:

• Insulin requirements can change during pregnancy. They tend to decrease in the 1st trimester and increase during the 2nd and 3rd trimesters.

Caution with Decreased Insulin Requirements:

• Be cautious when insulin requirements decrease due to factors like diarrhea, nausea/vomiting, malabsorption, hypothyroidism, renal impairment, or hepatic impairment.
• Hypokalemia (low potassium levels) may occur.

Administration Precautions:

• The medication should not be administered intravenously (IV) or intramuscularly (IM).

Caution with Increased Insulin Requirements:

• Exercise caution when insulin requirements increase due to fever, hyperthyroidism, trauma, infection, or surgery.

Lactation:

• It's generally safe to use Ansulin 30/70 Vial 40IU/ml while breastfeeding.

Renal and Hepatic Impairment:

• Be cautious and use with care in individuals with renal or hepatic impairment. Dosage adjustments might be necessary.

✔️ Storage Conditions

Store in a refrigerator (2-8°C). Do not freeze.