Generic Name: Metformin Hydrochloride 500mg
Manufacturer/Distributor: Pacific Pharmaceuticals Ltd.
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Indications
A medication called Metfo XR 500 is used to treat type 2 diabetes mellitus. It aids in blood sugar regulation and averts serious diabetic complications as a result. Additionally, it is used to treat polycystic ovary syndrome (PCOS) that affects women and is related to menstruation. It's best to take Metfo XR 500 with food to prevent nausea and discomfort in the stomach.
Pharmacology
The biguanide class of oral antihyperglycemic drug metformin is used to treat type 2 diabetes. It lowers plasma glucose levels at rest and after meals. It works in a different way from sulfonylureas and doesn't result in hypoglycemia. By increasing peripheral glucose uptake and utilization, metformin decreases hepatic glucose synthesis, lowers intestinal glucose absorption, and improves insulin sensitivity.
Dosage & Administration
Metformin Extended Release Tablet:
Always swallow the entire Metformin XR tablet without crushing, chewing, or cutting it.
Patient with renal impairment:
Metformin Immediate Release Tablet:
The dosage of Metformin Hydrochloride must be tailored to the patient's unique needs in order to maximize effectiveness and minimize side effects.
Interaction
Co-administration of topiramate and zonisamide with carbonic anhydrase may raise the risk of lactic acidosis. Metformin buildup may be increased by drugs that decrease Metformin clearance (Ranolazine, Dolutegravir, Cimetidine). Metformin's effect on lactate metabolism can be exacerbated by alcohol.
Contraindications
Side Effects
Pregnancy & Lactation
Pregnancy: Uncontrolled diabetes (whether gestational or permanent) increases the risk of congenital malformations and perinatal death. When a patient intends to become pregnant or is pregnant, it is advised that diabetes not be treated with metformin, but that insulin is used to keep blood glucose levels as close to normal as possible in order to decrease the risk of fetal abnormalities.
Breastfeeding: Metformin can be found in human breast milk. There were no negative effects detected in breastfed newborns/infants. However, due to the scarcity of evidence, nursing is not advised on metformin medication. The choice to cease nursing should be taken after considering the benefits of breastfeeding as well as the potential danger of harmful consequences on the child.
Precautions & Warnings
Metformin Hydrochloride is significantly eliminated through the kidney, and the risk of Metformin buildup and lactic acidosis increases with the degree of renal function impairment. Metformin has been linked to a decrease in vitamin B12 levels. When used with insulin or an insulin secretagogue, it also raises the risk of hypoglycemia.
Storage Conditions
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
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