Magolin 5 Tablet 1 Strip

Mirogabalin is a gamma-amino acid derivative that selectively binds to the α2δ subunits of voltage-gated calcium channels (VGCCs). By reducing calcium influx into nerve cells, it decreases the release of pain-signaling neurotransmitters, helping to reduce nerve pain and calm overactive nerve activity.

After oral administration, Mirogabalin is rapidly absorbed, with peak blood levels reached within 0.5–1.5 hours. It has low plasma protein binding (approximately 25%) and is primarily eliminated unchanged through the kidneys. A small portion is metabolized by the liver. Its average elimination half-life ranges from 2 to 5 hours.

Dosage & Administration

Adults

• Initial dose: 5 mg twice daily
• Increase by 5 mg per dose at intervals of at least one week
• Usual maintenance dose: 10–15 mg twice daily, depending on the patient's condition and response.

Children & Adolescents

• Safety and effectiveness have not been established.

Hepatic Impairment

• No significant adverse effects have been observed after a single 15 mg dose in patients with mild to moderate liver impairment.
• Insufficient data are available for patients with severe hepatic impairment.

Renal Impairment

• Mild impairment: Start with 5 mg twice daily, increase gradually to 10 mg twice daily.
• Moderate impairment: Start with 2.5 mg twice daily, increase gradually to 7.5 mg twice daily.
• Severe impairment: Start with 2.5 mg once daily, increase gradually to 7.5 mg once daily.

Drug Interactions

With medicines

• Cimetidine and Probenecid may increase Mirogabalin blood levels.
• Lorazepam may enhance the sedative effects of Mirogabalin.
• Medicines that inhibit OAT1, OAT3, OCT2, MATE1, MATE2-K, or UGT transporters may increase Mirogabalin exposure and should be used cautiously.

With food and alcohol

• Food does not significantly affect absorption.
• Avoid alcohol, as it can increase drowsiness, dizziness, and impair coordination.

Contraindications

Do not use Magolin if you have:

• Hypersensitivity to Mirogabalin or any of its ingredients.
• Mild to moderate hepatic or renal impairment (as stated in the provided source).

Side Effects

Common

• Drowsiness (somnolence)
• Dizziness
• Swelling (edema)
• Weight gain

Seek immediate medical attention if you experience

• Severe dizziness or loss of consciousness
• Extreme drowsiness
• Persistent nausea or vomiting
• Loss of appetite
• Yellowing of the skin or eyes (jaundice), which may indicate liver problems

Pregnancy & Breastfeeding

• Use during pregnancy only if the expected benefit outweighs the potential risk to the fetus.
• Animal studies indicate transfer across the placenta and into breast milk. Breastfeeding decisions should be made in consultation with a healthcare provider.

Precautions & Warnings

• Magolin may cause dizziness, drowsiness, blurred vision, or double vision. Avoid driving or operating heavy machinery until you know how it affects you.
• Elderly patients have an increased risk of falls and fractures.
• Weight gain may occur during treatment.
• If signs of an allergic reaction develop, stop taking the medicine and seek medical advice immediately.
• Dose adjustment is required in patients with impaired kidney function.
• Inform your doctor about all other medicines you are taking before starting treatment.

Therapeutic Class

• Primary Anti-epileptic Drugs
• Adjunct Anti-epileptic Drugs

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of the reach of children.