Glucozid MR 30mg Tablet

✔️ Uses of Glucozid MR 30mg Tablet

• Type 2 Diabetes Mellitus

✔️ How does Glucozid MR 30mg Tablet work?

Glucozid MR 30mg Tablet is an anti-diabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood sugar levels.

✔️ Side Effects of Glucozid MR 30mg Tablet

• Stomach ache or indigestion
• Feeling sick (nausea)
• Being sick (vomiting)
• Diarrhea
• Constipation
• Hypoglycemia (low blood sugar levels)

✔️ Quick Suggestions:

• Fill half of your plate with starchy vegetables, one-quarter with proteins, and the remaining quarter with whole grains.
• Eat at regular intervals and avoid long gaps between meals or snacks to prevent blood sugar fluctuations.
• Regularly monitor your blood sugar levels, especially when you notice significant fluctuations.
• Aim for gradual weight loss to achieve a healthy body mass index (BMI) between 18.5 and 24.9.
• Choose omega-3 fatty acid-containing oils for daily cooking and use oils like palm oil, groundnut oil, mustard oil, rice bran oil, and safflower oil for frying. Limit saturated fats found in chips, crisps, pastries, and biscuits.
• Manage stress through techniques like mindfulness, yoga, or meditation, as stress can impact blood sugar levels.
• Keep your blood pressure within the normal range (120/80mmHg) to reduce the risk of cardiovascular issues associated with diabetes.
• Take Gliclazide with or just before your first main meal of the day (typically breakfast). Avoid skipping meals.
• Gliclazide can cause hypoglycemia when used with other antidiabetic medicines, alcohol, or when meals are delayed or missed. Carry sugary foods or fruit juice to manage hypoglycemic symptoms.
• Your doctor may monitor your liver function regularly. Inform them if you experience symptoms like abdominal pain, loss of appetite, or jaundice.
• Take Gliclazide as prescribed by your doctor and at regular intervals if you're using it multiple times a day. Inform your healthcare provider before using over-the-counter medicines, herbal products, or supplements alongside Gliclazide.
• Your doctor will guide you on recognizing and managing early symptoms of high or low blood sugar levels.

✔️ Indication

• Glucozid MR 30mg Tablet: An anti-diabetic medication for type 2 Diabetes mellitus.
• Controls blood sugar levels, averting complications like blindness, kidney damage, stroke, and heart attack.
• Enhances insulin production, regulating blood sugar and lowering excess levels.

✔️ Pharmacology

Gliclazide, a second-generation sulfonylurea, possesses hypoglycemic and potential hematological impacts. It curbs glucose production from the liver and encourages insulin secretion from pancreatic beta-cells by facilitating calcium ion transport through the cell membranes.

✔️ Dosage & Administration of Glucozid MR 30mg Tablet

Film-coated Tablet:

• Initial dose: 40 to 80 mg per day.
• Maximum dose: Up to 320 mg per day in divided doses as needed.
• Take it before meals.
• Not recommended for children with juvenile-onset diabetes.

Modified Release Tablets:

• Gliclazide 30 mg: 1 to 4 tablets daily as a single dose.
• Gliclazide 60 mg: 1 to 2 tablets daily as a single dose.
• Take it at breakfast time.
• Preferably take it before breakfast to minimize digestive disturbances.

Overdosage:

• In case of an accidental overdose of Glucozid MR 30mg Tablet, immediately consult a doctor or go to a nearby hospital.
• Symptoms of overdose may include signs of low blood glucose levels like weakness, sweating, trembling, fast heartbeat, confusion, and double vision.

Missed Dose:

If you missed a dose of Glucozid MR 30mg Tablet, take it as soon as you remember. If it is almost time for your next, skip the missed dose. Do not take two doses together to make up for a missed dose.

✔️ Interaction

• Prior to taking Glucozid MR 30mg Tablet, inform your doctor if you're using any of the following medications:
• Other antidiabetic drugs like metformin, insulin, glipizide, glibenclamide, dapagliflozin, teneligliptin, etc.
• Antifungal medicines such as miconazole or fluconazole
• St. John's Wort (used for depression)
• Antibiotics like fluoroquinolones, clarithromycin, co-trimoxazole, rifampicin, chloramphenicol, tetracyclines, or sulphonamides
• Medications for high blood pressure or heart failure including beta-blockers, ACE inhibitors
• Drugs for stomach ulcers like ranitidine, famotidine
• Antidepressants like moclobemide, isocarboxazid, phenelzine, tranylcypromine
• Pain relief medications like aspirin, phenylbutazone, ibuprofen
• Medicines containing alcohol, such as cough preparations
• Medications for mental illness like chlorpromazine, prochlorperazine, lithium
• Corticosteroids like prednisolone, cortisone, betamethasone
• Asthma medications like salbutamol, terbutaline
• Ritodrine (used to prevent premature labor)
• Danazol (for breast disorders, heavy menstrual bleeding, and endometriosis)
• Blood-thinning drugs like warfarin
• Diuretics like bendroflumethiazide, hydrochlorothiazide, furosemide
• Oral contraceptives (birth control pills)
• Sulfinpyrazone (for gout)
• Aminoglutethimide (for breast or prostate cancer)
• Thyroid hormones like thyroxine
• Octreotide (for gut bleeding)
• Testosterone (for delayed puberty in men)
• Cimetidine (for stomach ulcers)
• Clofibrate (for high blood cholesterol)
• Disopyramide (for irregular heartbeats)
• Laxatives like lactulose, ispagula

✔️ Contraindications

Gliclazide is contraindicated in the following cases:

• Juvenile-onset (type-1) diabetes
• Diabetes Associated with Ketosis
• Diabetic patients undergoing surgery, after severe injury, or during infection
• Patients with hypersensitivity to sulfonylurea drugs
• Pregnant women and breastfeeding mothers
• Individuals with hepatic insufficiency

✔️ Pregnancy & Lactation

Pregnant women should avoid taking gliclazide. It should not be used by a mother who is breastfeeding.

✔️ Precautions & Warnings

Glucozid MR 30mg Tablet should not be used if you have:

• Type I diabetes (insulin-dependent diabetes)
• Diabetic ketoacidosis (high sugar and ketone levels)
• Diabetic coma or pre-coma
• Serious traumatic injury
• G6PD deficiency (inherited blood disorder)
• Porphyria (inherited blood disorder)

Before using Glucozid MR 30mg Tablet, inform your doctor if you:

• Are malnourished, on an irregular diet, or feeling weak
• Engage in intense physical activity
• Have hormonal issues (pituitary, adrenal, thyroid disorders)

Use in Pediatrics:

• Not recommended for children and adolescents (<18 years).
• Consult your doctor before using.

Use in Geriatrics:

• Use cautiously in the elderly, especially with CNS depressants or beta-blockers.
• Consult your doctor before use.

Hypoglycemia:

• Hypoglycemia is characterized by low blood sugar levels.
• If prone to low blood sugar episodes, use Glucozid MR 30mg Tablet cautiously.
• Keep your doctor informed and undergo regular blood glucose tests.

✔️ Storage Conditions

Store Glucozid MR 30mg Tablet below 25°C at a dry place, protected from light. Keep it away from children and pets.