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Glucostat 80 is used for managing Type 2 Diabetes Mellitus as part of a comprehensive treatment plan that includes diet and exercise.
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✅ Description:
Gliclazide belongs to the class of sulfonylureas and works by stimulating insulin release from the pancreatic beta cells. It also decreases hepatic glucose production and improves peripheral insulin sensitivity. Additionally, it reduces the risk of microvascular complications by decreasing platelet aggregation and enhancing fibrinolytic activity through increased tissue plasminogen activator (t-PA) levels.
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✔️ Dosage & Administration of Glucostat 80
- Immediate-Release Tablet: Start with 40–80 mg orally once daily; gradually adjust to 320 mg/day as needed. Doses above 160 mg/day should be split into two doses.
- Modified-Release Tablet: Start with 30 mg once daily, increasing in 30 mg increments (maximum 120 mg/day), with dose adjustments made at intervals of at least one month. In non-responsive patients, dosage may be increased after two weeks.
It should be taken with or 30 minutes before meals.
Swallow the tablet whole without chewing, breaking, or crushing.
Always take this medicine as directed by your physician.
✔️ Words of Advice:
- Take with your first major meal of the day.
- Don’t skip meals while on this medication.
- Be cautious when driving or using machinery until you know how it affects you.
- Always carry a source of sugar (like juice or glucose tablets) to counter potential hypoglycemic episodes.
- Inform your doctor if you notice signs of liver trouble, like jaundice or abdominal pain.
✔️ Side Effects of Glucostat 80
- Nausea
- Indigestion
- Upset stomach
- Less Common but Serious:
- Vomiting, diarrhea, gastritis
- Skin rashes or allergic reactions
- Liver issues like cholestatic jaundice
- Changes in blood cell counts: leucopenia, thrombocytopenia, agranulocytosis, hemolytic anemia
- Elevated liver enzymes
✔️
May increase the risk of low blood sugar when taken with:
- Other antidiabetic drugs (e.g., insulin, metformin, acarbose)
- NSAIDs, sulfonamides, clarithromycin
- Beta-blockers, ACE inhibitors, H2-receptor blockers, MAO inhibitors
- Phenylbutazone, miconazole (potentially fatal interaction)
May decrease effectiveness when taken with:
- Glucocorticoids, danazol, chlorpromazine
- Beta-agonists (salbutamol, terbutaline, ritodrine)
- May enhance the effect of warfarin, increasing bleeding risk
✔️ Contraindications
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
- Severe liver or kidney dysfunction
- Known allergy to gliclazide or sulfonylureas
- Pregnancy and breastfeeding
✔️ Precautions & Warnings
- Monitor blood glucose regularly.
- May require insulin temporarily during illness or surgery.
- Use caution when switching from combination antidiabetic therapies.
- Increased risk of hypoglycemia in the elderly, debilitated patients, or those with liver/kidney impairment.
- Avoid alcohol and ensure regular meals to prevent low blood sugar.
✔️ Storage:
Store in a cool & dry place, protected from light & moisture.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
