Cefotil Plus 250mg Tablet

Uses of Cefotil Plus 250 Tablet

• Cystitis
• Pyelonephritis
• Nongonococcal Urethritis
• Skin And Structure Infection
• Pneumonia
• Bronchitis
• Inhalation Anthrax
• Plague

How does Cefotil Plus 250 Tablet work?

Cefotil Plus 250 Tablet is a combination of cefuroxime and clavulanic acid. Cefuroxime is an antibiotic that works by preventing the formation of a protective coating on the bacteria, which is essential for their survival. Clavulanic acid is a beta-lactamase inhibitor that works by reducing resistance and enhancing the activity of cefuroxime against bacteria.

Side Effects of Cefotil Plus 250 Tablet

• Diarrhea
• Headache
• Difficult or painful urination
• Change in taste
• Abdominal pain
• Acid or sour stomach

Quick Suggestions:

• You have been prescribed this combination medicine to treat bacterial infections, even if they have developed resistance.
• Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat.
• Take it with food to avoid an upset stomach.
• Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
• Stop taking Cefotil Plus 250 and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while taking it.
• Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

Indication of Cefotil Plus 250 Tablet

• Cefotil Plus 250 Tablet is used to treat infections caused by bacteria that are susceptible to antibiotics.
• Streptococcus pyogenes causes pharyngitis and tonsillitis.
• Streptococcus pneumonia, Haemophilus influenza, Moraxella catarrhalis (beta-lactamase generating strains), or Streptococcus pyogenes cause acute bacterial otitis media.
• Streptococcus pneumonia or Haemophilus influenza induces acute bacterial maxillary sinusitis (non-beta-lactamase-producing strains)
• Streptococcus pneumonia, Haemophilus influenza (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, and E. coli cause lower respiratory tract infections.
• Streptococcus pneumonia, Haemophilus influenza (beta-lactamase negative strains), or Haemophilus parainfluenza cause acute bacterial aggravation of chronic bronchitis and secondary bacterial infections of acute bronchitis (beta-lactamase negative strains).
  Staphylococcus aureus (including beta-lactamase generating strains) or Streptococcus pyogenes infections of the skin and skin structures.
• E.coli or Klebsiella pneumonia infections of the urinary tract.
• Staphylococcus aureus infections of the bones and joints (penicillinase- and non-penicillinase-producing strains).
• Penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae cause gonorrhea.
• Borrelia burgdorferi causes early Lyme Disease (erythema migrans).

Pharmacology

Cefuroxime is a well-studied and potent antibacterial drug with broad-spectrum bactericidal activity against a variety of infections, including those that produce -lactamases. Cefuroxime is resistant to bacterial-lactamase and thus efficacious against a wide range of ampicillin- and amoxicillin-resistant strains.

Dosage & Administration of Cefotil Plus 250 Tablet

Adolescents and adults (13 years and older):

• Pharyngitis/tonsillitis: 250 mg twice daily for 5-10 days
• Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days
• Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days
• Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5-10 days
• Uncomplicated skin and skin structure infections: 250-500 mg twice daily for 10 days
• Uncomplicated urinary tract infections: 250 mg twice daily for 7-10 days
• Uncomplicated gonorrhea: 1000 mg twice daily as a single dose
• Community-acquired pneumonia: 250-500 mg twice daily for 5-10 days
• MDR (multidrug-resistant) typhoid fever: 500 mg twice daily for 10-14 days
• Early Lyme disease: 500 mg twice daily for 20 days

Pediatric patients (3 months to 12 years):

• Pharyngitis/tonsillitis: 20 mg/kg/day divided into two doses for 5-10 days
• Acute otitis media: 30 mg/kg/day divided into two doses for 10 days
• Acute bacterial maxillary sinusitis: 30 mg/kg/day divided into two doses for 10 days
• Impetigo: 30 mg/kg/day divided into two doses for 10 days

It's important to note that the cefuroxime-Clavulanic Acid tablet can be taken without regard to food.

As always, it's crucial to follow the dosage instructions provided by your healthcare provider and complete the full course of treatment to ensure the effective treatment of the bacterial infection.

Interaction

Interaction with Lab Test

The doctor should be informed if you are undergoing Ferricyanide test during the course of this medicine.

Interaction with Medicine

• Antacids such as sodium bicarbonate and aluminum hydroxide (used to treat stomach problems)
• Probenecid (used to treat gout)
• Oral contraceptives (combined oral estrogen/progesterone)
• Potent diuretics (Ex. chlorothiazide, indapamide)

Interaction with Disease

Do not use this medication if you suffer from colitis, liver disease and seizure disorders.

Contraindications

Cefuroxime is not recommended for people who have a Cephalosporin allergy.

Pregnancy & Lactation

Cefuroxime is classified as a pregnancy category B by the US Food and Drug Administration. However, no suitable and well-controlled studies in pregnant women have been conducted. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Human milk has been found to contain cefuroxime. When Cefuroxime is given to a nursing woman, caution should be observed.

Precautions & Warnings

• Allergy and pre-existing conditions: Inform your doctor if you have any allergies, especially to antibiotics, as well as kidney or liver problems before starting Cefotil Plus 250 Tablet 6's. Also, consult your doctor if you have colitis (inflammation of the colon).
• Self-medication: Avoid self-medication with Cefotil Plus 250 Tablet, as it can contribute to antibiotic resistance. Always consult your doctor before taking antibiotics.
• Concurrent treatment: If you are receiving concurrent treatment with potent diuretics, use Cefotil Plus 250 Tablet 6's with caution. Inform your doctor about all the medications you are taking.
• Pregnancy and breastfeeding: Consult your doctor before taking Cefotil Plus 250 Tablet 6's if you are pregnant or planning for pregnancy. Avoid taking Cefotil Plus 250 Tablet 6's if you are breastfeeding, as it may pass into breast milk.
• Alcohol and tobacco: Avoid alcohol consumption while taking Cefotil Plus 250 Tablet 6's, as it may cause unpleasant side effects. Additionally, it is advised to avoid tobacco usage.

Storage Conditions

Store in a cool, dry place (below 30° C), away from light & moisture. Keep out of the reach of children.